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Journal Articles

Reinforced antimyeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with bridging-BiTE

Tatsuya Konishi, Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Yukihiro Miyazaki, Chika Iwamoto, Takashi Saitou, Takeshi Imamura, Masaki Yasukawa, Katsuto Takenaka

Blood (2023) 142 (21): 1789–1805.

https://doi.org/10.1182/blood.2022019082

Published: 2023

Includes: Supplemental data

Journal Articles

Development of a New CAR-T-Cell Therapy Targeting an Immune Checkpoint for Effective Treatment of Solid and Liquid Tumors

Toshiki Ochi, Yuko Matsuoka, Tatsuya Konishi, Masaki Maruta, Yukihiro Miyazaki, Kazushi Tanimoto, Masaki Yasukawa, Masakatsu Yamashita, Katsuto Takenaka

Blood (2023) 142 (Supplement 1): 6823.

https://doi.org/10.1182/blood-2023-177852

Published: 2023

Journal Articles

Development of T-Cell Therapy By Exploiting Modified Antibodies Specific for A2/NY-ESO-1 for Refractory Myeloma

Masaki Maruta, MD, Toshiki Ochi, MD PhD, Kazushi Tanimoto, MD PhD, Taichi Azuma, MD PhD, Hiroshi Fujiwara, MD PhD, Masaki Yasukawa, MD PhD

Blood (2017) 130 (Supplement 1): 1913.

https://doi.org/10.1182/blood.V130.Suppl_1.1913.1913

Published: 2017

Journal Articles

Induction of WT1-specific human CD8 + T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice

Yuho Najima, Mariko Tomizawa-Murasawa, Yoriko Saito, Takashi Watanabe, Rintaro Ono, Toshiki Ochi, Nahoko Suzuki, Hiroshi Fujiwara, Osamu Ohara, Leonard D. Shultz, Masaki Yasukawa, Fumihiko Ishikawa

Blood (2016) 127 (6): 722–734.

https://doi.org/10.1182/blood-2014-10-604777

Published: 2016

Includes: Supplemental data

Journal Articles

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, MD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, PhD, Yukihiro Miyazaki, MD, PhD, Taichi Azuma, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2013) 122 (21): 144.

https://doi.org/10.1182/blood.V122.21.144.144

Published: 2013

Journal Articles

Development of a novel redirected T-cell–based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia

Yukihiro Miyazaki, Hiroshi Fujiwara, Hiroaki Asai, Fumihiro Ochi, Toshiki Ochi, Taichi Azuma, Takashi Ishida, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa

Blood (2013) 121 (24): 4894–4901.

https://doi.org/10.1182/blood-2012-11-465971

Published: 2013

Includes: Supplemental data

Journal Articles

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 3153.

https://doi.org/10.1182/blood.V120.21.3153.3153

Published: 2012

Journal Articles

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Yukihiro Miyazaki, MD, Fumihiro Ochi, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 4221.

https://doi.org/10.1182/blood.V120.21.4221.4221

Published: 2012

Journal Articles

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity

Kozo Nagai, Toshiki Ochi, Hiroshi Fujiwara, Jun An, Toshiaki Shirakata, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, J. Joseph Melenhorst, Emma Gostick, David A. Price, Eiichi Ishii, Masaki Yasukawa

Blood (2012) 119 (2): 368–376.

https://doi.org/10.1182/blood-2011-06-360354

Published: 2012

Includes: Supplemental data

Journal Articles

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Yukihiro Miyazaki, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 645.

https://doi.org/10.1182/blood.V118.21.645.645

Published: 2011

Journal Articles

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, PhD, Toshiaki Shirakata, MD, PhD, Kozo Nagai, MD, Yukihiro Miyazaki, MD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 2059.

https://doi.org/10.1182/blood.V118.21.2059.2059

Published: 2011

Journal Articles

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, Kozo Nagai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 4169.

https://doi.org/10.1182/blood.V118.21.4169.4169

Published: 2011

Journal Articles

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

Toshiki Ochi, Hiroshi Fujiwara, Sachiko Okamoto, Jun An, Kozo Nagai, Toshiaki Shirakata, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa

Blood (2011) 118 (6): 1495–1503.

https://doi.org/10.1182/blood-2011-02-337089

Published: 2011

Includes: Supplemental data

Journal Articles

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Jun An, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 1020.

https://doi.org/10.1182/blood.V116.21.1020.1020

Published: 2010

Journal Articles

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Kozo Nagai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, J. Joseph Melenhorst, PhD, Emma Gostic, David A Price, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4290.

https://doi.org/10.1182/blood.V116.21.4290.4290

Published: 2010

Journal Articles

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, An Jun, MD, Toshiaki Shirakata, Kozo Nagai, MD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4295.

https://doi.org/10.1182/blood.V116.21.4295.4295

Published: 2010

Journal Articles

Development of Novel Stem Cell Transplantation and Gene-Immunotherapy Using WT1-Specific T-Cell Receptor Gene.

Toshiki Ochi, MD, Hiroshi Fujiwara, MD, PhD, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Hiroshi Shiku, MD, PhD, Hidetoshi Ozawa, PhD, Fumihiko Ishikawa, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2009) 114 (22): 3028.

https://doi.org/10.1182/blood.V114.22.3028.3028

Published: 2009

Journal Articles

Development of a Novel Anti-Leukemia Gene Immunotherapy Using Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer.

Kozo Nagai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2009) 114 (22): 375.

https://doi.org/10.1182/blood.V114.22.375.375

Published: 2009

Journal Articles

Aurora-A kinase: a novel target of cellular immunotherapy for leukemia

Toshiki Ochi, Hiroshi Fujiwara, Koichiro Suemori, Taichi Azuma, Yoshihiro Yakushijin, Takaaki Hato, Kiyotaka Kuzushima, Masaki Yasukawa

Blood (2009) 113 (1): 66–74.

https://doi.org/10.1182/blood-2008-06-164889

Published: 2009

Includes: Supplemental data

Journal Articles

Aurora-a Kinase: A Novel Target of Cellular Immunotherapy for Human Leukemia

Toshiki Ochi, MD, Hiroshi Fujiwara, MD, PhD, Koichiro Suemori, MD, Taichi Azuma, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2008) 112 (11): 2904.

https://doi.org/10.1182/blood.V112.11.2904.2904

Published: 2008

NARROW

Reinforced antimyeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with bridging-BiTE

Development of a New CAR-T-Cell Therapy Targeting an Immune Checkpoint for Effective Treatment of Solid and Liquid Tumors

Development of T-Cell Therapy By Exploiting Modified Antibodies Specific for A2/NY-ESO-1 for Refractory Myeloma

Induction of WT1-specific human CD8 + T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Development of a novel redirected T-cell–based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Development of Novel Stem Cell Transplantation and Gene-Immunotherapy Using WT1-Specific T-Cell Receptor Gene.

Development of a Novel Anti-Leukemia Gene Immunotherapy Using Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer.

Aurora-A kinase: a novel target of cellular immunotherapy for leukemia

Aurora-a Kinase: A Novel Target of Cellular Immunotherapy for Human Leukemia

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American Society of Hematology

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American Society of Hematology

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