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Journal Articles

Elucidation of the Unique Function of GATA1s in the Development of Transient Abnormal Myeloproliferative Disorders

Yoko Nishinaka-Arai, Yohko Kitagawa, Yasuhiro Kazuki, Yasuyuki Arai, Tatsutoshi Nakahata, Akira Niwa, Megumu K Saito
Journal: Blood
Blood (2023) 142 (Supplement 1): 4121.
https://doi.org/10.1182/blood-2023-179017
Published: 2023
Journal Articles

IL-4 Acts at an Early Fate-Determining Junction in Hematopoiesis to Induce NK Cell Subsets Expressing Endogenous CD16

Saori Nakano, Akira Niwa, Yohko Kitagawa, Hidefumi Hiramatsu, Megumu K Saito
Journal: Blood
Blood (2023) 142 (Supplement 1): 1.
https://doi.org/10.1182/blood-2023-188768
Published: 2023
Journal Articles

Screening for Intracellular Phosphorylation Cascades That Positively and Negatively Regulate the Self-Renewing Proliferation of Immature HPCs

Sayaka Kitada, Yoko Nishinaka-Arai, Momoko Nishikori, Akira Niwa, Megumu K Saito
Journal: Blood
Blood (2023) 142 (Supplement 1): 4055.
https://doi.org/10.1182/blood-2023-183086
Published: 2023
Journal Articles

Enhancement of Human Neutrophil Bactericidal Activity through ROS Regulation

Misato Komori, Yoko Nishinaka-Arai, Momoko Nishikori, Akira Niwa, Megumu K Saito
Journal: Blood
Blood (2023) 142 (Supplement 1): 673.
https://doi.org/10.1182/blood-2023-180505
Published: 2023
Journal Articles

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes

Monika I. Linder, Yoko Mizoguchi, Sebastian Hesse, Gergely Csaba, Megumi Tatematsu, Marcin Łyszkiewicz, Natalia Ziȩtara, Tim Jeske, Maximilian Hastreiter, Meino Rohlfs, Yanshan Liu, Piotr Grabowski, Kaarin Ahomaa, Daniela Maier-Begandt, Marko Schwestka, Vahid Pazhakh, Abdulsalam I. Isiaku, Brenda Briones Miranda, Piers Blombery, Megumu K. Saito, Ejona Rusha, Zahra Alizadeh, Zahra Pourpak, Masao Kobayashi, Nima Rezaei, Ekrem Unal, Fabian Hauck, Micha Drukker, Barbara Walzog, Juri Rappsilber, Ralf Zimmer, Graham J. Lieschke, Christoph Klein
Journal: Blood
Blood (2023) 141 (6): 645–658.
https://doi.org/10.1182/blood.2022016783
Published: 2023
Includes: Supplemental data
Journal Articles

Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency

Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Kazuko Inoue, Keita Kondo, Masato T. Kanemaki, Tomonari Matsuda, Etsuro Ito, Seiji Kojima, Tatsutoshi Nakahata, Seishi Ogawa, Keigo Tanaka, Keitaro Matsuo, Megumu K. Saito, Minoru Takata
Journal: Blood
Blood (2021) 137 (15): 2021–2032.
https://doi.org/10.1182/blood.2020009111
Published: 2021
Includes: Supplemental data
Journal Articles

Defects in Signal Recognition Particle (SRP) Components Reveal an Essential and Non-Redundant Role for Granule Biogenesis and Differentiation of Neutrophil Granulocytes

Yoko Mizoguchi, MD PhD, Sebastian Hesse, MD, Monika Linder, PhD, Natalia Zietara, PhD, Marcin Lyszkiewicz, PhD, Yanshan Liu, PhD, Megumi Tatematsu, PhD, Piotr Grabowski, PhD, Kaarin Ahomaa, Tim Jeske, MSc, Sebastian Hollizeck, MSc, Ejona Rusha, Megumu K Saito, MD PhD, Masao Kobayashi, MD PhD, Zahra Alizadeh, PhD, Zahra Pourpak, MD PhD, Sorin Iurian, MD PhD, Nima Rezaei, MD PhD, Ekrem Unal, MD, Micha Drukker, PhD, Barbara Walzog, PhD, Fabian Hauck, MD PhD, Juri Rappsilber, PhD, Christoph Klein, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 216.
https://doi.org/10.1182/blood-2019-130083
Published: 2019
Journal Articles

NK Cells from Human Pluripotent Stem Cells for Immunotherapy

Hiroyuki Maysubara, Akira Niwa, MD, Tatsutoshi Nakahata, MD, PhD, Megumu K Saito, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4955.
https://doi.org/10.1182/blood-2018-99-115499
Published: 2018
Journal Articles

iPSC-Based Phenomic Screen Revealed an Impact of Uncontrolled NFkB Activity at the Initiating Stages of AML1-ETO Related Leukemia

Akira Niwa, MD PhD, Tatsutoshi Nakahata, MD, PhD, Megumu K Saito, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3911.
https://doi.org/10.1182/blood-2018-99-120218
Published: 2018
Journal Articles

Exogenously Added Cofilin Increases Ex Vivo Production of Functional Platelets By Stimulating Proplatelet Formation

Munetada Haruyama, Akira Niwa, MD, PhD, Megumu K Saito, MD, PhD, Tatsutoshi Nakahata, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3606.
https://doi.org/10.1182/blood.V130.Suppl_1.3606.3606
Published: 2017
Journal Articles

Identification of Candidate Progenitor Populations Which Causes Transient Abnormal Myelopoiesis

Yoko Nishinaka-Arai, PhD, Akira Niwa, MD, Shiori Matsuo, B.S., Yasuhiro Kazuki, PhD, Yuwna Yakura, PhD, Mitsuo Oshimura, PhD, Tatsutoshi Nakahata, MD, PhD, Megumu K Saito, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1659.
https://doi.org/10.1182/blood.V130.Suppl_1.1659.1659
Published: 2017
Journal Articles

Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA

Itaru Kato, Yoko Nishinaka, Masahiro Nakamura, Ayse U. Akarca, Akira Niwa, Hiroki Ozawa, Kenichi Yoshida, Makiko Mori, Dapeng Wang, Makiko Morita, Hiroo Ueno, Yusuke Shiozawa, Yuichi Shiraishi, Satoru Miyano, Rajeev Gupta, Katsutsugu Umeda, Kenichiro Watanabe, Katsuyoshi Koh, Souichi Adachi, Toshio Heike, Megumu K. Saito, Masashi Sanada, Seishi Ogawa, Teresa Marafioti, Akira Watanabe, Tatsutoshi Nakahata, Tariq Enver
Journal: Blood
Blood (2017) 129 (23): 3126–3129.
https://doi.org/10.1182/blood-2016-06-721712
Published: 2017
Includes: Supplemental data
Journal Articles

VEGFA- a New Therapeutic Target in CNS Leukemia

Itaru Kato, MD, PhD, Yoko Nishinaka-Arai, PhD, Masahiro Nakamura, MD PhD, Ayse U. Akarca, BSc, Akira Niwa, MD, PhD, Hiroki Ozawa, Kenichi Yoshida, MD PhD, Makiko Mori, MD, Dapeng Wang, PhD, Hiroo Ueno, MD, Yusuke Shiozawa, MD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Rajeev Gupta, MD, PhD, Katsutsugu Umeda, MD PhD, Kenichiro Watanabe, MD PhD, Katsuyoshi Koh, MD PhD, Souichi Adachi, MD, PhD, Toshio Heike, MDPhD, Megumu K Saito, MD, PhD, Masashi Sanada, MD PhD, Seishi Ogawa, MD PhD, Teresa Marafioti, MD, Akira Watanabe, PhD, Tatsutoshi Nakahata, MD PhD, Tariq Enver, PhD
Journal: Blood
Blood (2016) 128 (22): 911.
https://doi.org/10.1182/blood.V128.22.911.911
Published: 2016
Journal Articles

Hepatoma-Derived Growth Factor Is a Novel Factor to Promote the Proliferation of Hematopoietic Stem Cells

Munetada Haruyama, Kozo Yamaichi, Akira Niwa, MD, PhD, Megumu K Saito, MD, PhD, Tatsutoshi Nakahata, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1471.
https://doi.org/10.1182/blood.V128.22.1471.1471
Published: 2016
Journal Articles

PSC-Derived Hematopoietic System to Elucidate the Cooperation Between Gene Alterations and Cell Lineages in Leukemogenesis

Akira Niwa, MD, PhD, Megumu K Saito, MD, PhD, Tatsutoshi Nakahata, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1522.
https://doi.org/10.1182/blood.V128.22.1522.1522
Published: 2016
Journal Articles

Induction of Natural Killer Cells from Human Pluripotent Stem Cells Under Chemically Defined Condition

Hiroyuki Matsubara, Master, Akira Niwa, MD, PhD, Tatsutoshi Nakahata, MD PhD, Megumu K Saito, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 1345.
https://doi.org/10.1182/blood.V128.22.1345.1345
Published: 2016
Journal Articles

Recapitulation of Transient Abnormal Myelopoiesis Using Patient Derived iPSCs

Yoko Nishinaka-Arai, PhD, Akira Niwa, MD, PhD, Mitsujiro Osawa, PhD, Tatsutoshi Nakahata, MD, PhD, Megumu K Saito, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 4115.
https://doi.org/10.1182/blood.V126.23.4115.4115
Published: 2015
Journal Articles

Exploring the Pathogenesis of Down Syndrome-Related Myeloproliferative Disorders Using iPSCs

Nishinaka Yoko, PhD, Akira Niwa, MDPhD, Mitsujiro Osawa, PhD, Akira Watanabe, PhD, Tatsutoshi Nakahata, MD PhD, Megumu K Saito, MD PhD
Journal: Blood
Blood (2014) 124 (21): 868.
https://doi.org/10.1182/blood.V124.21.868.868
Published: 2014
Journal Articles

Phenomic Screen in Vivo and in Vitro to Explore Novel Pathogenesis of AML1-ETO-Positive Leukemia Using PSC-Derived Hematopoietic Cells

Akira Niwa, MDPhD, Akitsu Hotta, PhD, Megumu K Saito, MD PhD, Tatsutoshi Nakahata, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2370.
https://doi.org/10.1182/blood.V124.21.2370.2370
Published: 2014
Journal Articles

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

Takayuki Tanaka, Kazutoshi Takahashi, Mayu Yamane, Shota Tomida, Saori Nakamura, Koichi Oshima, Akira Niwa, Ryuta Nishikomori, Naotomo Kambe, Hideki Hara, Masao Mitsuyama, Nobuhiro Morone, John E. Heuser, Takuya Yamamoto, Akira Watanabe, Aiko Sato-Otsubo, Seishi Ogawa, Isao Asaka, Toshio Heike, Shinya Yamanaka, Tatsutoshi Nakahata, Megumu K. Saito
Journal: Blood
Blood (2012) 120 (6): 1299–1308.
https://doi.org/10.1182/blood-2012-03-417881
Published: 2012
Includes: Supplemental data