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Journal Articles

Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis

Hirofumi Shibata, Takahiro Yasumi, Saeko Shimodera, Eitaro Hiejima, Kazushi Izawa, Tomoki Kawai, Ryutaro Shirakawa, Taizo Wada, Ryuta Nishikomori, Hisanori Horiuchi, Osamu Ohara, Eiichi Ishii, Toshio Heike

Blood (2018) 131 (18): 2016–2025.

https://doi.org/10.1182/blood-2017-10-812503

Published: 2018

Includes: Supplemental data

Journal Articles

Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA

Blood (2017) 129 (23): 3126–3129.

https://doi.org/10.1182/blood-2016-06-721712

Published: 2017

Includes: Supplemental data

Journal Articles

VEGFA- a New Therapeutic Target in CNS Leukemia

Blood (2016) 128 (22): 911.

https://doi.org/10.1182/blood.V128.22.911.911

Published: 2016

Journal Articles

Dysregulation of DNA Methylation Involves in Progression of Myeloid Leukemia in Down Syndrome

Satoshi Saida, MD PhD, Masahiro Nakamura, MD PhD, Tsutomu Toki, PhD, Yoko Nishinaka-Arai, PhD, Kiminori Terui, MDPhD, Kenichi Yoshida, MD PhD, Seishi Ogawa, MD PhD, Tatsutoshi Nakahata, MD PhD, Toshio Heike, MD PhD, Ken-ichiro Watanabe, MD PhD, Akira Watanabe, PhD, Etsuro Ito, MD PhD

Blood (2015) 126 (23): 89.

https://doi.org/10.1182/blood.V126.23.89.89

Published: 2015

Journal Articles

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Blood (2013) 121 (21): 4377–4387.

https://doi.org/10.1182/blood-2012-12-474387

Published: 2013

Includes: Supplemental data

Journal Articles

Disease Modeling and Drug Discovery Using Induced Pluripotent Stem Cells From CINCA Syndrome Patients

Takayuki Tanaka, MD, Akira Ohta, PhD, Masakatsu Yanagimachi, MD, PhD, Ryuta Nishikomori, MD, PhD, Toshio Heike, MD, PhD, Tatsutoshi Nakahata, MD, PhD, Shinya Yamanaka, MD, PhD, Megumu Saito, MD, PhD

Blood (2012) 120 (21): 4680.

https://doi.org/10.1182/blood.V120.21.4680.4680

Published: 2012

Journal Articles

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

Blood (2012) 120 (6): 1299–1308.

https://doi.org/10.1182/blood-2012-03-417881

Published: 2012

Includes: Supplemental data

Journal Articles

Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency

Blood (2012) 119 (23): 5458–5466.

https://doi.org/10.1182/blood-2011-05-354167

Published: 2012

Includes: Supplemental data

Journal Articles

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Ph + Leukemia with T315I Mutation in Bcr-Abl; In Vivo Analysis Using Xenograft Mice Model

Satoshi Saida, MD, Itaru Kato, MD, Takeshi Inukai, MD, PhD, Atsushi Nemoto, MD, PhD, Kanji Sugita, MD, PhD, Yasuhiro Maeda, MD, PhD, Akira Niwa, MD, PhD, Ken-ichiro Watanabe, MD, PhD, Tatsutoshi Nakahata, MD, PhD, Toshio Heike, MD, PhD

Blood (2011) 118 (21): 2577.

https://doi.org/10.1182/blood.V118.21.2577.2577

Published: 2011

Journal Articles

Reduced Production of Mature Neutrophils From Induced Pluripotent Stem Cells Derived From a Severe Congenital Neutropenia Patient with HAX1 Gene Deficiency

Tatsuya Morishima, MD, Ken-ichiro Watanabe, MD, PhD, Akira Niwa, MD, PhD, Takayuki Tanaka, MD, Katsutsugu Umeda, MD, PhD, Hidefumi Hiramatsu, MD, PhD, Kousaku Matsubara, MD, PhD, Souichi Adachi, MD, PhD, Tatsutoshi Nakahata, MD, PhD, Toshio Heike, MD, PhD

Blood (2011) 118 (21): 2402.

https://doi.org/10.1182/blood.V118.21.2402.2402

Published: 2011

Journal Articles

Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein

Yuuki Murata, Takahiro Yasumi, Ryutaro Shirakawa, Kazushi Izawa, Hidemasa Sakai, Junya Abe, Naoko Tanaka, Tomoki Kawai, Koichi Oshima, Megumu Saito, Ryuta Nishikomori, Osamu Ohara, Eiichi Ishii, Tatsutoshi Nakahata, Hisanori Horiuchi, Toshio Heike

Blood (2011) 118 (5): 1225–1230.

https://doi.org/10.1182/blood-2011-01-329540

Published: 2011

Includes: Supplemental data

Journal Articles

Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/γc Null Mouse

Itaru Kato, Akira Niwa, Megumu Saito, Hisanori Fujino, Satoshi Saida, Hidefumi Hiramatsu, Koichi Oshima, Mamoru Ito, Souichi Adachi, MD, PhD, Toshio Heike, MD, Tatsutoshi Nakahata, MD

Blood (2010) 116 (21): 3248.

https://doi.org/10.1182/blood.V116.21.3248.3248

Published: 2010

Journal Articles

A Novel Mutation K673R In STAT1 Impaired the STAT1 Signal Transduction In a dominant– Negative Manner Identified In a Japanese Boy with MSMD

Yoko Mizoguchi, MD, Miyuki Tsumura, B.Sc., Satoshi Okada, MD, Hidemasa Sakai, MD, Ryuta Nishikomori, MD, Shin'ichiro Yasunaga, MD, Motoaki Ohtsubo, PhD, Takuji Murata, MD, Hideto Obata, MD, Takahiro Yasumi, MD, Toshio Heike, MD, Tatsutoshi Nakahata, MD, Yoshihiro Takihara, MD, Masao Kobayashi, MD

Blood (2010) 116 (21): 1734.

https://doi.org/10.1182/blood.V116.21.1734.1734

Published: 2010

Journal Articles

Analyzing the Stepwise Developmental Pathway From ES/IPS Cells to Functional Mature Erythrocytes.

Akira Niwa, M.D., Tomoki Fukatsu, Katsutsugu Umeda, M.D., PhD., Itaru Kato, M.D., Hiromi Sakai, PhD., Tatsuya Morishima, M.D., Keisuke Okita, PhD., Shinya Yamanaka, M.D., PhD., Toshio Heike, M.D., PhD., Tatsutoshi Nakahata, M.D., Ph.D.

Blood (2009) 114 (22): 2534.

https://doi.org/10.1182/blood.V114.22.2534.2534

Published: 2009

Journal Articles

Blockage of SDF-1-CXCR4 Axis by AMD 3100 Can Be a Novel Therapy for Acute Lymphoblastic Leukemia by Targeting the Extramedullary Sites of Leukemic Cells.

Itaru Kato, M.D., Akira Niwa, M.D., Hisanori Fujino, M.D., PhD., Katsutsugu Umeda, M.D., PhD., Satoshi Saida, M.D., Souichi Adachi, MD, PhD, Mamoru Ito, Toshio Heike, M.D., PhD., Tatsutoshi Nakahata, M.D., Ph.D.

Blood (2009) 114 (22): 981.

https://doi.org/10.1182/blood.V114.22.981.981

Published: 2009

Journal Articles

NOD/SCID/γ c null mice provide a Unique Model to Investigate Childhood Haematopoietic Malignancies

Itaru Kato, M.D., Akira Niwa, M.D., Katsutsugu Umeda, M.D., Ph.D., Mamoru Ito, Ph.D., Toshio Heike, M.D., Ph.D., Tatsutoshi Nakahata, M.D., Ph.D.

Blood (2008) 112 (11): 3963.

https://doi.org/10.1182/blood.V112.11.3963.3963

Published: 2008

Journal Articles

Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients

Blood (2008) 111 (4): 2132–2141.

https://doi.org/10.1182/blood-2007-06-094201

Published: 2008

Includes: Supplemental data

Journal Articles

Disease-associated mutations in CIAS1 induce cathepsin B–dependent rapid cell death of human THP-1 monocytic cells

Akihiro Fujisawa, Naotomo Kambe, Megumu Saito, Ryuta Nishikomori, Hideaki Tanizaki, Nobuo Kanazawa, Souichi Adachi, Toshio Heike, Junji Sagara, Takashi Suda, Tatsutoshi Nakahata, Yoshiki Miyachi

Blood (2006) 109 (7): 2903–2911.

https://doi.org/10.1182/blood-2006-07-033597

Published: 2006

Includes: Supplemental data

Journal Articles

Different Kinetics and Function of Vascular Endothelial Growth Factor Recepotor-1 and −2 during Hemangioblast Development from Primate Embryonic Stem Cells.

Katsutsugu Umeda, MD, PhD, Toshio Heike, MD, PhD, Gen Shinoda, MD, Akira Niwa, MD, Masato Arai, MD, Hiroshi Matsubara, MD, Feng Ma, MD, PhD, Souichi Adachi, MD, PhD, Hirofumi Suemori, PhD, Ryuzo Torii, PhD, Masabumi Shibuya, PhD, Norio Nakatsuji, PhD, Tatsutoshi Nakahata, MD, PhD

Blood (2006) 108 (11): 3920.

https://doi.org/10.1182/blood.V108.11.3920.3920

Published: 2006

Journal Articles

α4-Integrin + Endothelium Derived from Primate Embryonic Stem Cells Generates Both Primitive and Definitive Hematopoietic Cells.

Gen Shinoda, MD, Katsutsugu Umeda, MD, PhD, Toshio Heike, MD, PhD, Masato Arai, MD, Akira Niwa, MD, Feng Ma, MD, PhD, Hirofumi Suemori, PhD, Hong Yuan Luo, PhD, David H.K. Chui, MD, Ryuzo Torii, PhD, Masabumi Shibuya, PhD, Norio Nakatsuji, PhD, Tatsutoshi Nakahata, MD, PhD

Blood (2006) 108 (11): 683.

https://doi.org/10.1182/blood.V108.11.683.683

Published: 2006

NARROW

Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis

Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA

VEGFA- a New Therapeutic Target in CNS Leukemia

Dysregulation of DNA Methylation Involves in Progression of Myeloid Leukemia in Down Syndrome

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Disease Modeling and Drug Discovery Using Induced Pluripotent Stem Cells From CINCA Syndrome Patients

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Ph + Leukemia with T315I Mutation in Bcr-Abl; In Vivo Analysis Using Xenograft Mice Model

Reduced Production of Mature Neutrophils From Induced Pluripotent Stem Cells Derived From a Severe Congenital Neutropenia Patient with HAX1 Gene Deficiency

Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein

Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/γc Null Mouse

A Novel Mutation K673R In STAT1 Impaired the STAT1 Signal Transduction In a dominant– Negative Manner Identified In a Japanese Boy with MSMD

Analyzing the Stepwise Developmental Pathway From ES/IPS Cells to Functional Mature Erythrocytes.

Blockage of SDF-1-CXCR4 Axis by AMD 3100 Can Be a Novel Therapy for Acute Lymphoblastic Leukemia by Targeting the Extramedullary Sites of Leukemic Cells.

NOD/SCID/γ c null mice provide a Unique Model to Investigate Childhood Haematopoietic Malignancies

Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients

Disease-associated mutations in CIAS1 induce cathepsin B–dependent rapid cell death of human THP-1 monocytic cells

Different Kinetics and Function of Vascular Endothelial Growth Factor Recepotor-1 and −2 during Hemangioblast Development from Primate Embryonic Stem Cells.

α4-Integrin + Endothelium Derived from Primate Embryonic Stem Cells Generates Both Primitive and Definitive Hematopoietic Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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