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Tsutomu Toki
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Journal Articles

Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms

Clinical Trials & Observations
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko M. Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Journal: Blood
Blood (2024) 143 (25): 2627–2643.
https://doi.org/10.1182/blood.2023022247
Published: 2024
Includes: Supplemental data
Journal Articles

BRAF V600E-Positive Precursors As Molecular Markers of Bone Marrow Involvement in Pediatric Langerhans Cell Histiocytosis

Ko Kudo, MD, Rika Kanezaki, PhD, Akie Kobayashi, MD, Tomohiko Sato, MD PhD, Takuya Kamio, MD PhD, Shinya Sasaki, MD PhD, Imamura Masaru, MD PhD, Chihaya Imai, MD PhD, Masahiro Irie, MD PhD, Yoji Sasahara, MD PhD, Kumiko Ando, MD, Harumi Kakuda, MD PhD, Takehiko Doi, MD PhD, Hiroshi Kawaguchi, MD PhD, Kazuko Kudo, MD PhD, Hirokazu Kanegane, MD PhD, Kiminori Terui, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3588.
https://doi.org/10.1182/blood-2019-127536
Published: 2019
Journal Articles

Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A / 2B copy Number Alterations

Yusuke Hara, Tomohiko Taki, MD PhD, Genki Yamato, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD PhD, Norio Shiba, MD PhD, Taeko Kaburagi, MD, Yuichi Shiraishi, PhD, Kentaro Ohki, MD PhD, Machiko Kawamura, MD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Hidemasa Matsuo, PhD, Akira Shimada, MD PhD, Tsutomu Toki, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Keizo Horibe, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2727.
https://doi.org/10.1182/blood-2019-126263
Published: 2019
Journal Articles

Predictive Factors of the Development of Leukemia in Patients with Transient Abnormal Myelopoiesis and Down Syndrome: The Jccg Study JPLSG TAM-10

Genki Yamato, MD PhD, Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, PhD, Takao Deguchi, MD PhD, Shotaro Iwamoto, MD, Daisuke Hasegawa, MD PhD, Kiminori Terui, MD PhD, Takahiro Ueda, MD PhD, Tomoko Yokosuka, Tsutomu Toki, PhD, Shiro Tanaka, PhD, Ryu Yanagisawa, Katsuyoshi Koh, MD, Akiko M Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Kenichiro Watanabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3833.
https://doi.org/10.1182/blood-2019-125465
Published: 2019
Journal Articles

Post-Induction Minimal Residual Disease Measured By Flow Cytometry and Deep Sequencing of Mutant GATA1 Are Both Significant Prognostic Factors for Children with Myeloid Leukemia and Down Syndrome: A Nationwide Prospective Study of the Japanese Pediatric Leukemia/Lymphoma Study Group

Takashi Taga, MD PhD, Shiro Tanaka, PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD, Hidefumi Hiramatsu, MD PhD, Takako Miyamura, MD PhD, Yoshiko Hashii, MD PhD, Daisuke Hasegawa, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Katsuyoshi Koh, MD, Daiichiro Hasegawa, MD PhD, Asahito Hama, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3848.
https://doi.org/10.1182/blood-2019-123302
Published: 2019
Journal Articles

Comprehensive Genomic Analysis Identified Acute Lymphoblastic Leukemia in Down Syndrome Was Highly Heterogeneous with the High Prevalence of Ph-like Signature

Yasuo Kubota, MD, Kumiko Uryu, MD PhD, Tatsuya Ito, MD, Masafumi Seki, MD,PhD, Tomoya Isobe, MD, Tsutomu Toki, PhD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, MItsuteru Hiwatari, MD PhD, Satoru Miyano, PhD, Akira Oka, MD PhD, Seishi Ogawa, MD PhD, Kiminori Terui, MD PhD, Atsushi Sato, MD, Etsuro Ito, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2817.
https://doi.org/10.1182/blood-2018-99-111080
Published: 2018
Journal Articles

Integrated Genetic/Epigenetic Analysis Revealed High Heterogeneity of Acute Lymphoblastic Leukemia in Down Syndrome

Yasuo Kubota, MD, Kumiko Uryu, MD PhD, Tatsuya Ito, MD, Tomoko Kawai, PhD, Masafumi Seki, MD,PhD, Tomoya Isobe, Tsutomu Toki, PhD, Kenichi Yoshida, MD PhD, Keisuke Kataoka, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Satoru Miyano, PhD, Akira Oka, MD PhD, Yasuhide Hayashi, Seishi Ogawa, MD PhD, Kiminori Terui, MD PhD, Atsushi Sato, MD, Kenichiro Hata, MD PhD, Etsuro Ito, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3975.
https://doi.org/10.1182/blood.V130.Suppl_1.3975.3975
Published: 2017
Journal Articles

Analysis of GATA1 Mutations in Down Syndrome Infants with Transient Abnormal Myelopoiesis and Clinical Impacts of GATA1 Mutation Types: A Report from the JPLSG TAM-10 Study

Kiminori Terui, MD PhD, Tsutomu Toki, PhD, Asahito Hama, MD PhD, Hideki Muramatsu, MD PhD, Daisuke Hasegawa, MD PhD, Myoung-Ja Park, MD PhD, Shotaro Iwamoto, MD PhD, Takashi Taga, MD PhD, Ryu Yanagisawa, MD PhD, Katsuyoshi Koh, MD, Akiko M. Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD, PhD, Shuki Mizutani, MD, PhD, Kenichiro Watanabe, MD PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2865.
https://doi.org/10.1182/blood.V128.22.2865.2865
Published: 2016
Journal Articles

Gene Expression Profiles and Methylation Analysis in Down Syndrome Related Acute Lymphoblastic Leukemia

Yasuo Kubota, MD, Kumiko Uryu, MD, Tomoko Kawai, Tatsuya Ito, MD, Isamu Hanada, MD PhD, Tsutomu Toki, PhD, Masafumi Seki, MD PhD, Kenichi Yoshida, MD PhD, Keisuke Kataoka, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Satoru Miyano, PhD, Akira Oka, MD PhD, Yasuhide Hayashi, MD PhD, Seishi Ogawa, MD PhD, Kiminori Terui, MD PhD, Atsushi Sato, MD PhD, Kenichiro Hata, Etsuro Ito, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4084.
https://doi.org/10.1182/blood.V128.22.4084.4084
Published: 2016
Journal Articles

Dysregulation of DNA Methylation Involves in Progression of Myeloid Leukemia in Down Syndrome

Satoshi Saida, MD PhD, Masahiro Nakamura, MD PhD, Tsutomu Toki, PhD, Yoko Nishinaka-Arai, PhD, Kiminori Terui, MDPhD, Kenichi Yoshida, MD PhD, Seishi Ogawa, MD PhD, Tatsutoshi Nakahata, MD PhD, Toshio Heike, MD PhD, Ken-ichiro Watanabe, MD PhD, Akira Watanabe, PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2015) 126 (23): 89.
https://doi.org/10.1182/blood.V126.23.89.89
Published: 2015
Journal Articles

Prospective Study of 168 Infants with Transient Abnormal Myelopoiesis with Down Syndrome: Japan Pediatric Leukemia/Lymphoma Study Group, TAM-10 Study

Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, Daisuke Hasegawa, MD PhD, Park Myoung-ja, Shotaro Iwamoto, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Tsutomu Toki, PhD, Kiminori Terui, Ryu Yanagisawa, Katsuyoshi Koh, MD PhD, Akiko M. Saito, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, MD PhD, Kenichiro Watanabe
Journal: Blood
Blood (2015) 126 (23): 1311.
https://doi.org/10.1182/blood.V126.23.1311.1311
Published: 2015
Journal Articles

RAS Pathway Mutations in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Tatsuya Ito, MD, Kiminori Terui, MDPhD, Isamu Hanada, MD PhD, Fumika Ikeda, MD, Tsutomu Toki, PhD, Rika Kanezaki, PhD, Tomohiko Sato, MD PhD, Takuya Kamio, MDPhD, Ko Kudo, MD, Shinya Sasaki, MD PhD, Yoshihiro Takahashi, MD PhD, Yasuhide Hayashi, MD PhD, Takeshi Inukai, MD PhD, Hiroki Hori, MD PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4986.
https://doi.org/10.1182/blood.V126.23.4986.4986
Published: 2015
Journal Articles

Risk-Oriented Therapy for Myeloid Leukemia of Down Syndrome: A Nationwide Prospective Study By the Japanese Pediatric Leukemia / Lymphoma Study Group (JPLSG)

Takashi Taga, MD PhD, Tomoyuki Watanabe, Kazuko Kudo, MDPhD, Daisuke Tomizawa, MD PhD, Kiminori Terui, MD PhD, Hiroshi Moritake, MD PhD, Akitoshi Kinoshita, MD PhD, Shotaro Iwamoto, MD PhD, Hideki Nakayama, MD PhD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Hiroaki Goto, MD, PhD, Katsuyoshi Koh, MD, Akiko M. Saito, MD PhD, Keizo Horibe, MD PhD, Tatsutoshi Nakahata, MD PhD, Akio Tawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3668.
https://doi.org/10.1182/blood.V124.21.3668.3668
Published: 2014
Journal Articles

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Satoshi Saida, Ken-ichiro Watanabe, Aiko Sato-Otsubo, Kiminori Terui, Kenichi Yoshida, Yusuke Okuno, Tsutomu Toki, RuNan Wang, Yuichi Shiraishi, Satoru Miyano, Itaru Kato, Tatsuya Morishima, Hisanori Fujino, Katsutsugu Umeda, Hidefumi Hiramatsu, Souichi Adachi, Etsuro Ito, Seishi Ogawa, Mamoru Ito, Tatsutoshi Nakahata, Toshio Heike
Journal: Blood
Blood (2013) 121 (21): 4377–4387.
https://doi.org/10.1182/blood-2012-12-474387
Published: 2013
Includes: Supplemental data
Journal Articles

Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome

Brief Report
Tsutomu Toki, Rika Kanezaki, Eri Kobayashi, Hiroshi Kaneko, Mikiko Suzuki, RuNan Wang, Kiminori Terui, Hirokazu Kanegane, Miho Maeda, Mikiya Endo, Tatsuki Mizuochi, Souichi Adachi, Yasuhide Hayashi, Masayuki Yamamoto, Ritsuko Shimizu, Etsuro Ito
Journal: Blood
Blood (2013) 121 (16): 3181–3184.
https://doi.org/10.1182/blood-2012-01-405746
Published: 2013
Includes: Supplemental data
Journal Articles

Identification of Two New DBA Genes, RPS27 and RPL27 , by Whole-Exome Sequencing in Diamond-Blackfan Anemia Patients

Etsuro Ito, Kenichi Yoshida, MD, Yusuke Okuno, MD, PhD, Aiko Sato-Otsubo, PhD, Tsutomu Toki, PhD, Satoru Miyano, PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Kiminori Terui, MD, PhD, RuNan Wang, MD, Tomohiko Sato, MD, PhD, Yuji Iribe, PhD, Shouichi Ohga, MD, PhD, Madoka Kuramitsu, PhD, Isao Hamaguchi, MD, PhD, Akira Ohara, Kazuko Kudo, Isamu Kamimaki, MD, PhD, Junichi Hara, MD, PhD, Kanji Sugita, MD, PhD, Kousaku Matsubara, MD, PhD, Kenichi Koike, MD, PhD, Akira Ishiguro, MD, PhD, Yoshifumi Kawano, MD, PhD, Hitoshi Kanno, MD, PhD, Seiji Kojima, MD, PhD, Seishi Ogawa, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 984.
https://doi.org/10.1182/blood.V120.21.984.984
Published: 2012
Journal Articles

Genetic Basis of Myeloid Proliferation Related to Down Syndrome

Kenichi Yoshida, MD, Tsutomu Toki, PhD, Myoung-ja Park, MD, PhD, Yusuke Okuno, MD, PhD, Yuichi Shiraishi, PhD, Masashi Sanada, MD, Ayana Kon, MD, Yasunobu Nagata, MD, Aiko Sato-Otsubo, PhD, Yusuke Sato, MD, RuNan Wang, MD, Kiminori Terui, MD, PhD, Rika Kanezaki, MS, Norio Shiba, MD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Asahito Hama, MD, PhD, Daisuke Hasegawa, MD, PhD, Kazuhiro Nakamura, MD, PhD, Hirokazu Kanegane, MD, PhD, Keiko Tsukamoto, MD, PhD, Souichi Adachi, MD, PhD, Satoru Miyano, PhD, Seiji Kojima, Shai Izraeli, MD, Yasuhide Hayashi, MD, PhD, Etsuro Ito, Seishi Ogawa, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 535.
https://doi.org/10.1182/blood.V120.21.535.535
Published: 2012
Journal Articles

Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia

Brief Report
Takashi Yokoyama, Tsutomu Toki, Yoshihiro Aoki, Rika Kanezaki, Myoung-ja Park, Yohei Kanno, Tomoko Takahara, Yukari Yamazaki, Etsuro Ito, Yasuhide Hayashi, Takuro Nakamura
Journal: Blood
Blood (2012) 119 (11): 2608–2611.
https://doi.org/10.1182/blood-2010-12-324806
Published: 2012
Includes: Supplemental data
Journal Articles

Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia

Madoka Kuramitsu, Aiko Sato-Otsubo, Tomohiro Morio, Masatoshi Takagi, Tsutomu Toki, Kiminori Terui, RuNan Wang, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Toshiyuki Kitoh, Kumiko Goi, Kazuko Kudo, Tadashi Matsubayashi, Nobuo Mizue, Michio Ozeki, Atsuko Masumi, Haruka Momose, Kazuya Takizawa, Takuo Mizukami, Kazunari Yamaguchi, Seishi Ogawa, Etsuro Ito, Isao Hamaguchi
Journal: Blood
Blood (2012) 119 (10): 2376–2384.
https://doi.org/10.1182/blood-2011-07-368662
Published: 2012
Includes: Supplemental data
Journal Articles

GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome

Tsutomu Toki, PhD, Eri Kobayashi, MS, Rika Kanezaki, MS, RuNan Wang, MD, Kiminori Terui, MD, PhD, Hirokazu Kanegane, MD, PhD, Miho Maeda, MD, PhD, Mikiya Endo, MD, PhD, Tatsuki Mizuochi, MD, PhD, Souichi Adachi, MD, PhD, Yasuhide Hayashi, MD, PhD, Ritsuko Shimizu, MD, PhD, Masayuki Yamamoto, MD, PhD, Etsuro Ito, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1491.
https://doi.org/10.1182/blood.V118.21.1491.1491
Published: 2011