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Karen Akinsanya
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Journal Articles

Sgr-2921, a Potent CDC7 Inhibitor, Demonstrates Significant Anti-Leukemic Responses in Patient-Derived AML Models Representing Difficult-to-Treat Disease

Hooman Izadi, Hui Wang, Christian Atsriku, Zef Konst, Adam Levinson, Joseph Piccotti, Steven Pirie-Shepherd, Lin Tang, Dan Weiss, Karen Akinsanya, Hamish Wright, Kristian K Jensen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2801.
https://doi.org/10.1182/blood-2023-181826
Published: 2023
Journal Articles

Sgr-1505 Is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile

Wu Yin, Min Ye, Netonia Marshall, Joanne BL Tan, Evan Paull, Zhe Nie, MIchael Trzoss, Goran Krilov, Shulu Feng, Robert Pelletier, Jeff Bell, Peter Skrdla, David Calkins, MaryBeth Grimes, D. Hamish Wright, Karen Akinsanya
Journal: Blood
Blood (2023) 142 (Supplement 1): 2997.
https://doi.org/10.1182/blood-2023-190985
Published: 2023
Journal Articles

A First-in-Human, Phase 1, Dose Escalation Study of Sgr-2921 As Monotherapy in Subjects with Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Courtney D. DiNardo, Stephen Anthony Strickland, Barry Skikne, Amer M. Zeidan, Elie Traer, Hetty E. Carraway, Stanley Frankel, Daniel E Weiss, Jacky H Wang, Steven Pirie-Shepherd, Joseph Piccotti, D. Hamish Wright, Karen Akinsanya
Journal: Blood
Blood (2023) 142 (Supplement 1): 1548.
https://doi.org/10.1182/blood-2023-186036
Published: 2023
Journal Articles

A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of Sgr-1505 As Monotherapy in Subjects with Mature B-Cell Malignancies

Adam Olszewski, David Kahn, Brian Yoo, Joanne BL Tan, Vipul K Gupta, Edgar Schuck, Zhe Nie, Goran Krilov, D. Hamish Wright, Daniel Weiss, Jean Lachowicz, Karen Akinsanya, Wu Yin
Journal: Blood
Blood (2023) 142 (Supplement 1): 3102.
https://doi.org/10.1182/blood-2023-182838
Published: 2023
Journal Articles

Inhibition of CDC7 with Sgr-2921 in AML Models Results in Enhanced DNA Damage and Anti-Leukemic Activity As Monotherapy and in Combination with Standard of Care Agents

Lyuben Tsvetkov, Janét Pittsenbarger, Christian Atsriku, Paul Devine, Karen Dingley, Adam Levinson, Sayan Mondal, Joseph Piccotti, Roman Shimanovich, Lin Tang, Daniel Weiss, Jacky Woo, Min Ye, Wu Yin, Karen Akinsanya, Wayne Tang, Hamish Wright, Elie Traer, Kristian Jensen
Journal: Blood
Blood (2022) 140 (Supplement 1): 5961–5962.
https://doi.org/10.1182/blood-2022-167239
Published: 2022
Journal Articles

Characterization of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Wu Yin, Zhe Nie, Karen Dingley, Michael Trzoss, Goran Krilov, Netonia Marshall, Shulu Feng, Robert Pelletier, Jeff Bell, Paul Devine, Peter Skrdla, Roman Shimanovich, Min Ye, David Calkins, Mary Grimes, Wayne Tang, Andrew Placzek, Morgan Lawrenz, Fiona McRobb, Aleksey Gerasyuto, Victoria Feher, Sayan Mondal, Kristian Jensen, Hamish Wright, Daniel Weiss, Karen Akinsanya
Journal: Blood
Blood (2021) 138 (Supplement 1): 1187.
https://doi.org/10.1182/blood-2021-153159
Published: 2021
Journal Articles

Identification of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Wu Yin, PhD, Nie Zhe, PhD, Andrew Placzek, PhD, Michael Trzoss, PhD, Goran Krilov, PhD, Shulu Feng, PhD, Morgan Lawrenz, PhD, Robert Pelletier, PhD, George Lai, PhD, Jeff Bell, PhD, David Calkins, Mary Grimes, Wayne Tang, PhD, Fiona McRobb, PhD, Aleksey Gerasyuto, PhD, Victoria Feher, PhD, Sayan Mondal, PhD, Kristian Jensen, PhD, Hamish Wright, PhD, Karen Akinsanya, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30.
https://doi.org/10.1182/blood-2020-141146
Published: 2020