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Journal Articles

First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies

Steven W. Pipe, MD, Michael Recht, MD PhD, Nigel S. Key, MD, Frank W.G. Leebeek, MD PhD, Giancarlo Castaman, MD, Susan U. Lattimore, R.N., Paul Van Der Valk, Kathelijne Peerlinck, MD PhD, Michiel Coppens, MD, Niamh O'Connell, MD PhD, John Pasi, MB, ChB, PhD FRCP, FRCPath, FRCPCH, Peter Kampmann, MD, Karina Meijer, MD PhD, Annette von Drygalski, MD Pharm D, Guy Young, MD, Cedric Hermans, MDMRCP,PhD, Jan Astermark, MD PhD, Robert Klamroth, MD PhD, Richard S. Lemons, MD, Nathan Visweshwar, MD, Shelley Crary, MD MS, Rashid Kazmi, MBBS, Emily Symington, Miguel A. Escobar, MD, Esteban Gomez, MD, Rebecca Kruse-Jarres, MD, Adam Kotowski, MD, Doris Quon, MD PhD, Michael Wang, MD, Allison P. Wheeler, MD, Eileen K Sawyer, PhD, Stephanie Verweij, BSc, Valerie Colletta, MSc, Naghmana Bajma, MD, Robert Gut, MD PhD, Wolfgang A. Miesbach, MD PhD

Blood (2020) 136 (Supplement_2): LBA-6.

https://doi.org/10.1182/blood-2020-143560

Published: 2020

Journal Articles

AMT-060 Gene Therapy in Adults with Severe or Moderate-Severe Hemophilia B Confirm Stable FIX Expression and Durable Reductions in Bleeding and Factor IX Consumption for up to 5 Years

Frank W.G. Leebeek, MD PhD, Karina Meijer, MD PhD, Michiel Coppens, MD, Peter Kampmann, MD, Robert Klamroth, Roger Schutgens, MD PhD MSc, Giancarlo Castaman, MD, Erhard Seifried, MD PhD, Joachim Schwaeble, Halvard Bönig, Eileen K Sawyer, PhD, Wolfgang A. Miesbach, MD

Blood (2020) 136 (Supplement 1): 26.

https://doi.org/10.1182/blood-2020-139225

Published: 2020

Journal Articles

Semiautomatic VWF Multimer Densitometric Analysis: Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease

Ferdows Atiq, Johan Boender, MD, Marjon H. Cnossen, MD PhD, Johanna G van der Bom, MD PhD, Karin Fijnvandraat, MD PhD, Joke de Meris, Moniek P.M. de Maat, PhD, Karin P.M. Van Galen, MD MSc, PhD, Britta A.P. Laros-Van Gorkom, MD PhD, Karina Meijer, MD PhD, Jeroen C.J. Eikenboom, MD PhD, Frank W.G. Leebeek, MD PhD

Blood (2020) 136 (Supplement 1): 15–16.

https://doi.org/10.1182/blood-2020-142287

Published: 2020

Journal Articles

Interim Results from a Dose Escalating Study of AMT-060 (AAV5-hFIX) Gene Transfer in Adult Patients with Severe Hemophilia B

Frank W.G. Leebeek, MD PhD, Marco Tangelder, MD PhD, Karina Meijer, MD PhD, Giancarlo Castaman, Federica Cattaneo, MD, Michiel Coppens, MD PhD, Peter Kampmann, MD, Robert Klamroth, Roger E.G. Schutgens, MD PhD, Erhard Seifried, MD PhD, Joachim Schwaeble, MD, Halvard Boenig, MD PhD, Maaike Hendriks, Deya Corzo, MD FAAP, Wolfgang A. Miesbach, MD PhD

Blood (2016) 128 (22): 2314.

https://doi.org/10.1182/blood.V128.22.2314.2314

Published: 2016

Journal Articles

No Association Between Normalization of VWF Levels and Bleeding Phenotype in Patients with Type 1 VWD - from the Win Study

Johan Boender, MD, Jeroen Eikenboom, MD PhD, Karin Fijnvandraat, MD PhD, Waander van Heerde, PhD, Karina Meijer, MD PhD, Evelien Mauser-Bunschoten, MD PhD, Marjon Cnossen, MD PhD, Joke de Meris, Britta Laros-van Gorkom, MD PhD, Anske van der Bom, MD PhD, Frank W.G. Leebeek, MD PhD

Blood (2016) 128 (22): 2577.

https://doi.org/10.1182/blood.V128.22.2577.2577

Published: 2016

Journal Articles

Incidence and Risk Factors for Venous Thrombosis in Human Immunodeficiency Virus (HIV) Infection, Data from the Dutch Athena Cohort Study

James Francis Borjas-Howard, MD MSc, Casper Rokx, MD PhD, Colette Smit, PhD, Ferdinand Wit, MD PhD, Elise Pieterman, MD MSc, Karina Meijer, MD PhD, Bart Rijnders, MD PhD, Wouter Bierman, MD PhD, Vladimir Tichelaar, MD PhD

Blood (2016) 128 (22): 271.

https://doi.org/10.1182/blood.V128.22.271.271

Published: 2016

Journal Articles

The Bleeding Risk of Vitamin K Antagonists Hardly Increases after the Age of 80 Years: Data from a Large Real-Life Cohort Study

Hilde Kooistra, MD, Agneta Calf, MD, Margriet Piersma-Wichers, MD, Gerbrand Izaks, MD, Nic Veeger, MSc, Karina Meijer, MD PhD

Blood (2015) 126 (23): 891.

https://doi.org/10.1182/blood.V126.23.891.891

Published: 2015

Journal Articles

Single-Nucleotide Variation Spectrum of the Factor XI Gene in Women with Heavy Menstrual Bleeding

Sophie Wiewel-Verschueren, MD, André B Mulder, MDPhD, Karina Meijer, MD PhD, René Mulder, PhD

Blood (2014) 124 (21): 4213.

https://doi.org/10.1182/blood.V124.21.4213.4213

Published: 2014

Journal Articles

Incidence of Thrombotic Events in Patients Admitted to a Dedicated Tuberculosis Center in the Netherlands

Jaime Borjas-Howard, MD M.Sc., Wouter FW Bierman, MD, PhD, Tjip S van der Werf, MD, PhD, Karina Meijer, MD PhD, Vladimir Tichelaar, MD PhD

Blood (2014) 124 (21): 2860.

https://doi.org/10.1182/blood.V124.21.2860.2860

Published: 2014

Journal Articles

Targeting Clotting Factor VIII Plasma Values in the Perioperative Setting in Hemophilia a: “Tackling a Moving Target” (“OPTI-CLOT” Studies)

Janske Lock, MD PhDstudent, Hendrika C.A.M. Hazendonk, MD PhDstudent, Ron A.A. Mathôt, Prof. Dr., Karina Meijer, MD PhD, Marjolein Peters, MD PhD, Paul Brons, Felix J.M. Van der Meer, MD PhD, Hannan Bouzariouh, MD, Mariette H.E. Driessens, PhD, Karin Fijnvandraat, MD PhD, Frank W.G. Leebeek, MD PhD, Marjon H. Cnossen, MD PhD

Blood (2014) 124 (21): 5031.

https://doi.org/10.1182/blood.V124.21.5031.5031

Published: 2014

Journal Articles

Towards Successful Implementation of Pharmacokinetic-Guided Prophylactic Dosing of Clotting Factor Concentrate in Hemophilia; The Do’s and Don’ts after Discrete Choice Experiment Analysis

Janske Lock, MD PhDstudent, Esther W. de Bekker-Grob, PhD, Gamze Urhan, MD, Saskia Middeldorp, MD PhD, Marjolein Peters, MD PhD, Karina Meijer, MD PhD, Rienk Y.J. Tamminga, MD PhD, Britta Laros-van Gorkum, MD PhD, Paul Brons, Felix J.M. Van der Meer, MD PhD, Mariette H.E. Driessens, PhD, Peter W. Collins, MD, Karin Fijnvandraat, MD PhD, Frank W.G. Leebeek, MD PhD, Marjon H. Cnossen, MD PhD

Blood (2014) 124 (21): 5038.

https://doi.org/10.1182/blood.V124.21.5038.5038

Published: 2014

Journal Articles

Clinical Outcome After Occurrence Of Vitamin K-Antagonist Related Major Bleeding Complication: A Two-Year Observational Follow-Up Study

Nakisa Khorsand, Pharm D, Reinier M van Hest, Pharm D, PhD, Shakiba Zahedin Labbaf, MSc, Paula Ypma, MD, Helga W Vermaas, MD, Nic J.G.M. Veeger, PhD, Karina Meijer, MD PhD

Blood (2013) 122 (21): 2382.

https://doi.org/10.1182/blood.V122.21.2382.2382

Published: 2013

Journal Articles

A Cohort Study Of 15,912 Patients On The Long-Term Quality Of Vka Therapy After Extreme Overanticoagulation

Hilde A.M. Kooistra, MD, Nakisa Khorsand, PharmD, Hanneke C. Kluin-Nelemans, Nic J.G.M. Veeger, PhD, Margriet Piersma, MD, Karina Meijer, MD, PhD

Blood (2013) 122 (21): 2384.

https://doi.org/10.1182/blood.V122.21.2384.2384

Published: 2013

Journal Articles

A Systematic Review On Different Prothrombin Complex Concentrate Strategies To Reverse Vitamin K Antagonist Therapy

Nakisa Khorsand, Pharm D, Hilde A.M. Kooistra, MD, Reinier M. van Hest, Pharm D, PhD, Nic J.G.M. Veeger, PhD, Karina Meijer, MD PhD

Blood (2013) 122 (21): 3639.

https://doi.org/10.1182/blood.V122.21.3639.3639

Published: 2013

Journal Articles

Change in Body-Mass-Index and Persisting Symptoms After Pulmonary Embolism

Anja B.U. Mäkelburg, MD, Elke S. Hoendermis, MD PhD, Nic J.G.M. Veeger, PhD, J.C. Kluin-Nelemans, Karina Meijer, MD PhD

Blood (2012) 120 (21): 3389.

https://doi.org/10.1182/blood.V120.21.3389.3389

Published: 2012

Journal Articles

Women with Moderate and Severe Von Willebrand Disease Have a High Morbidity of Gynecological and Obstetric Bleeding

Eva de Wee, MD, Marieke Knol, MD, Eveline Mauser-Bunschoten, MD, PhD, Anske van der Bom, PhD, Manon Degenaar-Dujardin, BA, Jeroen C.J. Eikenboom, MD, PhD, Karin Fijnvandraat, MD, PhD, Arja de Goede-Bolder, MD, Britta Laros-van Gorkom, MD, PhD, Paula Ypma, MD, Sonja Zweegman, Karina Meijer, MD, PhD, Frank W.G. Leebeek, MD, PhD

Blood (2010) 116 (21): 542.

https://doi.org/10.1182/blood.V116.21.542.542

Published: 2010

Journal Articles

A Low Wells Score in a Hospital Setting May No Longer Safely Rule out Deep Vein Thrombosis: Preliminary Results From a Single-Center Prospective University-Hospital Study Involving 227 Patients.

Ynse IGV Tichelaar, MD, Karina Meijer, MD, PhD, Jan ter Maaten, MD, PhD, Matthijs Oudkerk, MD, PhD, Hanneke C. Kluin-Nelemans, MD, PhD, Willem M. Lijfering, MD, PhD

Blood (2009) 114 (22): 2469.

https://doi.org/10.1182/blood.V114.22.2469.2469

Published: 2009

Journal Articles

Willebrand in the Netherlands: WiN Study. Background and Study Design

Eva M. De Wee, MD, Eveline P. Mauser-Bunschoten, MD, PhD, Anske G. Van der Bom, PhD, Jeroen C.J. Eikenboom, MD, PhD, Karin J. Fijn van Draat, MD, PhD, Arja De Goede-Bolder, MD, Karina Meijer, MD, PhD, Irena Nováková, MD, PhD, Iris Plug, PhD, Frank W.G. Leebeek, MD, PhD

Blood (2008) 112 (11): 4510.

https://doi.org/10.1182/blood.V112.11.4510.4510

Published: 2008

NARROW

First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies

AMT-060 Gene Therapy in Adults with Severe or Moderate-Severe Hemophilia B Confirm Stable FIX Expression and Durable Reductions in Bleeding and Factor IX Consumption for up to 5 Years

Semiautomatic VWF Multimer Densitometric Analysis: Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease

Interim Results from a Dose Escalating Study of AMT-060 (AAV5-hFIX) Gene Transfer in Adult Patients with Severe Hemophilia B

No Association Between Normalization of VWF Levels and Bleeding Phenotype in Patients with Type 1 VWD - from the Win Study

Incidence and Risk Factors for Venous Thrombosis in Human Immunodeficiency Virus (HIV) Infection, Data from the Dutch Athena Cohort Study

The Bleeding Risk of Vitamin K Antagonists Hardly Increases after the Age of 80 Years: Data from a Large Real-Life Cohort Study

Single-Nucleotide Variation Spectrum of the Factor XI Gene in Women with Heavy Menstrual Bleeding

Incidence of Thrombotic Events in Patients Admitted to a Dedicated Tuberculosis Center in the Netherlands

Targeting Clotting Factor VIII Plasma Values in the Perioperative Setting in Hemophilia a: “Tackling a Moving Target” (“OPTI-CLOT” Studies)

Towards Successful Implementation of Pharmacokinetic-Guided Prophylactic Dosing of Clotting Factor Concentrate in Hemophilia; The Do’s and Don’ts after Discrete Choice Experiment Analysis

Clinical Outcome After Occurrence Of Vitamin K-Antagonist Related Major Bleeding Complication: A Two-Year Observational Follow-Up Study

A Cohort Study Of 15,912 Patients On The Long-Term Quality Of Vka Therapy After Extreme Overanticoagulation

A Systematic Review On Different Prothrombin Complex Concentrate Strategies To Reverse Vitamin K Antagonist Therapy

Change in Body-Mass-Index and Persisting Symptoms After Pulmonary Embolism

Women with Moderate and Severe Von Willebrand Disease Have a High Morbidity of Gynecological and Obstetric Bleeding

A Low Wells Score in a Hospital Setting May No Longer Safely Rule out Deep Vein Thrombosis: Preliminary Results From a Single-Center Prospective University-Hospital Study Involving 227 Patients.

Willebrand in the Netherlands: WiN Study. Background and Study Design

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American Society of Hematology

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American Society of Hematology

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