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Kenneth W Duncan
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Journal Articles

Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma

Jennifer Totman, Dorothy Brach, Vinny Motwani, Selene Howe, Emily Deutschman, John Lampe, Thomas V. Riera, Cuyue Tang, Sean T. Eckley, Josh Alford, Kenneth W. Duncan, Neil A. Farrow, Daniel T. Dransfield, Alejandra Raimondi, Michael J. Thomeius, Kat Cosmopoulos, Jeffery L Kutok
Journal: Blood
Blood (2021) 138 (Supplement 1): 1142.
https://doi.org/10.1182/blood-2021-151147
Published: 2021
Journal Articles

Identification of a First-in-Class SETD2 Inhibitor That Shows Potent and Selective Anti-Proliferative Activity in t(4;14) Multiple Myeloma: T(4;14) Multiple Myeloma Cells Are Dependent on Both H3K36 Di and Tri-Methylation

Michael J Thomenius, PhD BA, Jennifer Totman, Kat Cosmopoulos, Dorothy Brach, Lei Ci, Neil Farrow, Jesse J Smith, Richard Chesworth, Kenneth W. Duncan, Cuyue Tang, Thomas Riera, John Lampe
Journal: Blood
Blood (2018) 132 (Supplement 1): 3207.
https://doi.org/10.1182/blood-2018-99-110803
Published: 2018
Journal Articles

Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor

Elayne Chan-Penebre, Veronica Gibaja, John Campbell, Ogunbodede Olu, Elizabeth Admirand, Dorothy Brach, Cuyue Tang, Alejandra Raimondi, Tami Hood, Alexis Cocozaki, Sule Karaman, Kimberly Stickland, Christopher Plescia, Michael Munchhof, Kelli Armstrong, Thomas Riera, Stuart Orkin, Ann Boriack-Sjodin, William Janzen, Stephen Blakemore, Scott A Ribich, Richard Chesworth, Jesse J Smith, Kenneth W Duncan
Journal: Blood
Blood (2017) 130 (Supplement 1): 537.
https://doi.org/10.1182/blood.V130.Suppl_1.537.537
Published: 2017
Journal Articles

Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma

Elayne Penebre, PhD, Kristy G Kuplast, Christina R Majer, L. Danielle Johnston, MS, Nathalie Rioux, PhD, Michael Munchhof, PhD, Lei Jin, PhD, P. Ann Boriak-Sjodin, PhD, Tim J Wigle, PhD, Suzanne L Jacques, PhD, Kip A West, PhD, Trupti Lingaraj, Kimberly Stickland, PhD, Scott A Ribich, PhD, Alejandra Raimondi, MS, Margaret Porter-Scott, PhD, Nigel J Waters, PhD, Roy M Pollock, PhD, Jesse J Smith, PhD, Olena Barbash, PhD, Ryan G. Kruger, PhD, Robert A Copeland, PhD, Mikel P Moyer, PhD, Richard Chesworth, DPhil, Kenneth W Duncan, PhD
Journal: Blood
Blood (2014) 124 (21): 438.
https://doi.org/10.1182/blood.V124.21.438.438
Published: 2014