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Journal Articles

Sirolimus Augments Hematopoietic Stem and Progenitor Cell Recovery from Hematopoietic Stress

Xingmin Feng, PhD, Zenghua Lin, MD, Maile K. Hollinger, BA, Wanling Sun, MD PhD, Zhijie Wu, MD PhD, Kaylind Batey, BS, Keyvan Keyvanfar, BS, Jichun Chen, PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 1310.

https://doi.org/10.1182/blood-2018-99-113488

Published: 2018

Journal Articles

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

Lauren G. Banaszak, BS, Valentina Giudice, MD, Xin Zhao, MD PhD, Zhijie Wu, MD, Kohei Hosokawa, MD PhD, Keyvan Keyvanfar, BS, Danielle Townsley, MD, Sachiko Kajigaya, PhD, Neal S. Young

Blood (2016) 128 (22): 2704.

https://doi.org/10.1182/blood.V128.22.2704.2704

Published: 2016

Journal Articles

Crispr/Cas9-Mediated ASXL1 knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation

Zhijie Wu, MD, Xin Zhao, MD PhD, Lauren G. Banaszak, BS, Keyvan Keyvanfar, BS, Sachiko Kajigaya, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1529.

https://doi.org/10.1182/blood.V128.22.1529.1529

Published: 2016

Journal Articles

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Kohei Hosokawa, MDPhD, Sachiko Kajigaya, PhD, Keyvan Keyvanfar, BS, Qiao Wangmin, BS, Yanling Xie, MS, Olga Rios, RN, Barbara Weinstein, RN, Maria del Pilar Fernandez Ibanez, BS, Danielle M. Townsley, MD, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1042.

https://doi.org/10.1182/blood.V128.22.1042.1042

Published: 2016

Journal Articles

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Fernanda Gutierrez-Rodrigues, MSc, PharmD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Maria del Pilar Fernandez Ibanez, MS, Marie J. Desierto, BS, Keyvan Keyvanfar, BS, Zejuan Li, MD PhD, Soma Das, PhD, Rodrigo T. Calado, MD PhD, Danielle M. Townsley, MD, Neal S. Young

Blood (2016) 128 (22): 1044.

https://doi.org/10.1182/blood.V128.22.1044.1044

Published: 2016

Journal Articles

Oligoclonal Expansion of Effector Memory CD8+CD57+ T Cells May Sustain Bone Marrow Destruction in Aplastic Anemia

Valentina Giudice, MD, Xingmin Feng, PhD, Lin Zenghua, MD, Maria del Pilar Fernandez Ibanez, MS, Keyvan Keyvanfar, BS, Carmine Selleri, MD, Neal S. Young, MD

Blood (2016) 128 (22): 3898.

https://doi.org/10.1182/blood.V128.22.3898.3898

Published: 2016

Journal Articles

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Xingmin Feng, PhD, Delong Liu, PhD, Sachiko Kajigaya, PhD, Zhijie Wu, MD, Qingguo Liu, MD, Keyvan Keyvanfar, BS, Marie J. Desierto, BS, Danielle M. Townsley, MD, Xujing Wang, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 574.

https://doi.org/10.1182/blood.V128.22.574.574

Published: 2016

Journal Articles

Clofarabine Followed By Lenalidomide for Treatment of High Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia- Preliminary Clinical Outcomes and Potential Immune-Modulating Effects

Prachi Jain, MD, Sawa Ito, MD PhD, Neil Dunavin, MD, Jeffrey K. Klotz, MD, Kit Lu, MD, Eleftheria Koklanaris, RN, BSN, Debbie Draper, RN, BSN, Jeanine Superata, RN, Fariba Chinian, Quan Yu, MS, Keyvan Keyvanfar, BS, Susan Wong, Pawel Muranski, MD, John Barrett, MD, Minoo Battiwalla, MDMS

Blood (2016) 128 (22): 5553.

https://doi.org/10.1182/blood.V128.22.5553.5553

Published: 2016

Journal Articles

Selective Depletion of Alloreactive Donor T Cells with Adenosine: An Efficient, Scaleable, GMP-Compliant, Low-Cost Method to Prevent Gvhd While Preserving Antiviral and Antileukemic Activity in Haploidentical Stem Cell Transplant

Greg Whitehill, BS, Shoba Amarnath, BSc, MSc, PhD, Keyvan Keyvanfar, BS, Pawel Muranski, MD, Minoo Battiwalla, MDMS, Austin John Barrett, MDFRCP,FRCPath, Dhana Chinnasamy, PhD

Blood (2015) 126 (23): 380.

https://doi.org/10.1182/blood.V126.23.380.380

Published: 2015

Journal Articles

Whole Transcriptome Sequencing Identifies Novel Pathways Associated with Paroxysmal Nocturnal Hemoglobinuria- Increased CXCR2 Expression in PNH Granulocytes

Kohei Hosokawa, MDPhD, Sachiko Kajigaya, PhD, Keyvan Keyvanfar, BS, Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Marie Desierto, Olga Rios, Barbara Weinstein, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2015) 126 (23): 3608.

https://doi.org/10.1182/blood.V126.23.3608.3608

Published: 2015

Journal Articles

High Frequency of Circulating CD8 + Memory Stem T Cells in Acquired Aplastic Anemia

Kohei Hosokawa, MDPhD, Pawel Muranski, MD, Xingmin Feng, PhD, Danielle M. Townsley, MD, Baoying Liu, PhD, Jared Knickelbein, MD, Keyvan Keyvanfar, BS, Bogdan Dumitriu, MD, Sawa Ito, MD, Sachiko Kajigaya, PhD, James G. Taylor, MD, Mariana J. Kaplan, MD, Robert B. Nussenblatt, MD, Austin John Barrett, MDFRCP,FRCPath, John O'Shea, MD, Neal S. Young, MD

Blood (2015) 126 (23): 3613.

https://doi.org/10.1182/blood.V126.23.3613.3613

Published: 2015

Journal Articles

Rapamycin Is Highly Effective in a Mouse Model of Immune-Mediated Bone Marrow Failure By Mechanisms Distinct from Cyclosporine

Xingmin Feng, PhD, Zenghua Lin, MD PhD, Marie Desierto, Keyvan Keyvanfar, BS, Daniela Malide, PhD, Jichun Chen, PhD, Neal S. Young, MD

Blood (2015) 126 (23): 1202.

https://doi.org/10.1182/blood.V126.23.1202.1202

Published: 2015

Journal Articles

Adoptive T Cell Therapy for Polyomaviral Infections and Related Diseases

Dhana Chinnasamy, PhD, Greg Whitehill, BS, Keyvan Keyvanfar, BS, Isaac Brownell, MD PhD, Christopher Buck, PhD, Pawel Muranski, MD, Austin John Barrett, MDFRCP,FRCPath

Blood (2015) 126 (23): 4294.

https://doi.org/10.1182/blood.V126.23.4294.4294

Published: 2015

Journal Articles

T Cell Exhaustion and Downregulation of Cytotoxic NK Cells – an Immune Escape Mechanism in Adult Acute Lymphoblastic Leukemia

Eolia Brissot, Sawa Ito, MD, Kit Lu, MD, Carly Cantilena, B. Douglas Smith, Gabrielle Prince, Hossein Sadrzadeh, Amir T Fathi, Stephen A. Strickland, MD MSCI, Nancy F. Hensel, Fariba Chinian, M.S., Keyvan Keyvanfar, BS, Minoo Battiwalla, MDMS, Pawel Muranski, MD, Christopher S. Hourigan, MDPhD, John Barrett, MD

Blood (2014) 124 (21): 3781.

https://doi.org/10.1182/blood.V124.21.3781.3781

Published: 2014

Journal Articles

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Pawel Muranski, MD, Xingmin Feng, PhD, Keyvan Keyvanfar, BS, Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Jichun Chen, PhD, Sachiko Kajigaya, PhD, James G. Taylor, MD, Christopher S. Hourigan, MD PhD, John Barrett, MD, Neal S. Young, MD

Blood (2014) 124 (21): 2940.

https://doi.org/10.1182/blood.V124.21.2940.2940

Published: 2014

Journal Articles

A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency

Samantha Miner, Nancy F. Hensel, Bahey Salem, Neil Dunavin, MD, Kazushi Tanimoto, MD, Minoo Battiwalla, MD MS, Kit Lu, MD, Keyvan Keyvanfar, BS, Marianna Sabatino, David Stroncek, Patrick J Hanley, PhD, Catherine M. Bollard, MBChB, MD, Katayoun Rezvani, MD, PhD, Marcin Kortylewski, PhD, Pawel Muranski, MD, John Barrett, MD, Sawa Ito, MD

Blood (2014) 124 (21): 316.

https://doi.org/10.1182/blood.V124.21.316.316

Published: 2014

Journal Articles

Specific Impaired CD56+ NK Cell Development in GATA2 Deficiency As Revealed By Ex Vivo NK Expansion

Moonjung Jung, MD, Jan K. Davidson-Moncada, MD PhD, Chuanfeng Wu, PhD, Samson Koelle, BA, Thomas Winkler, MD, Danielle M. Townsley, MD, Amy Hsu, BS, Keyvan Keyvanfar, BS, Steven M. Holland, MD, Dennis D. Hickstein, MD, Richard W. Childs, MD, Cynthia E. Dunbar, MD

Blood (2014) 124 (21): 1419.

https://doi.org/10.1182/blood.V124.21.1419.1419

Published: 2014

Journal Articles

A Suppressive Microenvironment in Acute Myeloid Leukemia Induces Global Alteration of T and NK Cell Profiles - Evidence for Immune-Editing Effect By Leukemia

Sawa Ito, MD, John Barrett, MD, Bipin N. Savani, MD, Madan Jagasia, MBBS, MS, Eolia Brissot, Samantha Miner, Nancy F. Hensel, Fariba Chinian, M.S., Keyvan Keyvanfar, BS, Minoo Battiwalla, MD MS, Michael R Savona, MD, Sanjay Mohan, MD, Mattias Carlsten, MD PhD, Pawel Muranski, MD, Stephen A. Strickland, MD MSCI

Blood (2014) 124 (21): 1047.

https://doi.org/10.1182/blood.V124.21.1047.1047

Published: 2014

Journal Articles

Myeloid Leukemias Directly Suppress T Cell Proliferation Through STAT3 and Arginase Pathways

Samantha Miner, B.S., Sawa Ito, Kazushi Tanimoto, MD, Nancy F. Hensel, Fariba Chinian, M.S., Keyvan Keyvanfar, BS, Christopher S. Hourigan, MD, PhD, Minoo Battiwalla, MD, MS, J. Joseph Melenhorst, PhD, Pawel Muranski, MD, A. John Barrett

Blood (2013) 122 (21): 3885.

https://doi.org/10.1182/blood.V122.21.3885.3885

Published: 2013

Journal Articles

Alemtuzumab Achieved Durable Hematologic Response In Heavily Treated T-Large Granular Lymphocytosis Irrespective To STAT3 Mutation Or V-Beta Clone Size

Bogdan Dumitriu, MD, Phillip Scheinberg, MD, Sawa Ito, Nicole Stephens, BS, Yunce Muharrem, MD, Emily King, Sachiko Kajigaya, PhD, J. Joseph Melenhorst, PhD, Fariba Chinian, M.S., Keyvan Keyvanfar, BS, Minoo Battiwalla, MD, MS, Pawel Muranski, MD, Neal S. Young, MD, A. John Barrett

Blood (2013) 122 (21): 3705.

https://doi.org/10.1182/blood.V122.21.3705.3705

Published: 2013

NARROW

Sirolimus Augments Hematopoietic Stem and Progenitor Cell Recovery from Hematopoietic Stress

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

Crispr/Cas9-Mediated ASXL1 knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Oligoclonal Expansion of Effector Memory CD8+CD57+ T Cells May Sustain Bone Marrow Destruction in Aplastic Anemia

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Clofarabine Followed By Lenalidomide for Treatment of High Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia- Preliminary Clinical Outcomes and Potential Immune-Modulating Effects

Selective Depletion of Alloreactive Donor T Cells with Adenosine: An Efficient, Scaleable, GMP-Compliant, Low-Cost Method to Prevent Gvhd While Preserving Antiviral and Antileukemic Activity in Haploidentical Stem Cell Transplant

Whole Transcriptome Sequencing Identifies Novel Pathways Associated with Paroxysmal Nocturnal Hemoglobinuria- Increased CXCR2 Expression in PNH Granulocytes

High Frequency of Circulating CD8 + Memory Stem T Cells in Acquired Aplastic Anemia

Rapamycin Is Highly Effective in a Mouse Model of Immune-Mediated Bone Marrow Failure By Mechanisms Distinct from Cyclosporine

Adoptive T Cell Therapy for Polyomaviral Infections and Related Diseases

T Cell Exhaustion and Downregulation of Cytotoxic NK Cells – an Immune Escape Mechanism in Adult Acute Lymphoblastic Leukemia

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency

Specific Impaired CD56+ NK Cell Development in GATA2 Deficiency As Revealed By Ex Vivo NK Expansion

A Suppressive Microenvironment in Acute Myeloid Leukemia Induces Global Alteration of T and NK Cell Profiles - Evidence for Immune-Editing Effect By Leukemia

Myeloid Leukemias Directly Suppress T Cell Proliferation Through STAT3 and Arginase Pathways

Alemtuzumab Achieved Durable Hematologic Response In Heavily Treated T-Large Granular Lymphocytosis Irrespective To STAT3 Mutation Or V-Beta Clone Size

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American Society of Hematology

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American Society of Hematology

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