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Kirk Bertelsen
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Journal Articles

CD117 Antibody-Drug Conjugate Conditioning Allows Efficient Engraftment of Gene-Modified CD34+ Cells with Fertility Preservation in a Rhesus Gene Therapy Model

Naoya Uchida, Selami Demirci, Anh Le, Rebecca Chu, Xiong Liu, Ling Su, Xiaolin Wu, Allen Krouse, N Seth Linde, Aylin Bonifacino, So Gun Hong, Cynthia E. Dunbar, Leanne Lanieri, Anjali Bhat, Rahul Palchaudhuri, Bindu Bennet, Megan D. Hoban, Kirk Bertelsen, Lisa Olson, Robert Donahue, John F. Tisdale
Journal: Blood
Blood (2023) 142 (Supplement 1): 486.
https://doi.org/10.1182/blood-2023-177815
Published: 2023
Journal Articles

Mgta-117, an Anti-CD117 Antibody-Drug Conjugated with Amanitin, in Participants with Relapsed/Refractory Adult Acute Myeloid Leukemia (AML) and Myelodysplasia with Excess Blasts (MDS-EB): Safety, Pharmacokinetics and Pharmacodynamics Initial Findings from a Phase 1/2 Study

Peter Westervelt, Partow Kebriaei, Mark Juckett, Andrew S. Artz, Onyee Chan, Philip L. McCarthy, Sherif S Farag, Anurag K. Singh, Eytan Stein, Jeffrey Humphrey, William Baeder, Ji Hyun Lee, Alison Occhiuti, Jeanie Tang, David Santos, Kirk Bertelsen, Balaji Mahender, Nicole Henry, Shawn Rose
Journal: Blood
Blood (2022) 140 (Supplement 1): 2117–2119.
https://doi.org/10.1182/blood-2022-162406
Published: 2022
Journal Articles

The Pharmacokinetic and Pharmacodynamic Characterization of Mgta-117, an Anti-CD117-Amanitin Antibody-Drug Conjugate for Targeted Conditioning Prior to Transplant, in Nonhuman Primates

Kirk Bertelsen, Leanne Lanieri, Rahul Palchaudhuri, Lisa Olson
Journal: Blood
Blood (2022) 140 (Supplement 1): 10227–10228.
https://doi.org/10.1182/blood-2022-159712
Published: 2022
Journal Articles

A Phase 2, Open-Label Study to Evaluate the Efficacy and Safety of Mgta-145 in Combination with Plerixafor for the Mobilization of Hematopoietic Stem Cells in Patients with Sickle Cell Anemia

Akshay Sharma, John P Manis, David G. Justus, David A. Williams, Sergey Efuni, Ji Hyun Lee, Erin Conlin, Shawn Rose, Jeffrey Humphrey, Kirk Bertelsen, Nicole Henry, June Li, Donald Pardy, David Santos, Christian Zdybowicz, Alexis Leonard, John Tisdale
Journal: Blood
Blood (2022) 140 (Supplement 1): 8263–8264.
https://doi.org/10.1182/blood-2022-159728
Published: 2022
Journal Articles

CD117 Antibody Drug Conjugate-Based Conditioning Allows for Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model

Naoya Uchida, Ulana Stasula, Malikiya Hinds, Paula Germino-Watnick, Allen E. Krouse, N Seth Linde, Aylin C. Bonifacino, Kellie Latimer, Prashant Bhattarai, Nicholas C. Yoder, Rahul Palchaudhuri, Qing Li, Kirk Bertelsen, Lisa Olson, Robert E. Donahue, John F. Tisdale
Journal: Blood
Blood (2021) 138 (Supplement 1): 560.
https://doi.org/10.1182/blood-2021-145524
Published: 2021