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Journal Articles

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Hiroyuki Takamatsu, MDPhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-136893

Published: 2020

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Takeshi Yoroidaka, MD, Tanabe Mikoto, MD, Hiroki Mizumaki, MD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1216.

https://doi.org/10.1182/blood-2019-122798

Published: 2019

Journal Articles

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Tanabe Mikoto, MD, Dung Cao Tran, MD, Kohei Thi Hosokawa, MD PhD, Yoshitaka Zaimoku, MD PhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Fumihiro Azuma, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1215.

https://doi.org/10.1182/blood-2019-123266

Published: 2019

Journal Articles

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Tanabe Mikoto, MD, Nguyen Hoang Maianh, MD, Kohei Hosokawa, MD PhD, Noriharu Nakagawa, MD, Luis Espinoza, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3736.

https://doi.org/10.1182/blood-2019-126677

Published: 2019

Journal Articles

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Eiji Kobayashi, PhD, Yoshiki Akatsuka, MD PhD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Tanabe Mikoto, MD, Noriaki Tsuji, MD, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Thi Mai Anh Nguyen, MD, Takamasa Katagiri, PhD, Kiyomi Shitaoka, PhD, Hiroshi Hamana, PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3751.

https://doi.org/10.1182/blood-2019-125685

Published: 2019

Journal Articles

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Kohei Thi Hosokawa, MD PhD, Kohei Hosokawa, MD PhD, Tanabe Mikoto, MD, Md Mohiuddin, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD PhD, Masaya Ueno, PhD, Atsushi Hirao, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 5000.

https://doi.org/10.1182/blood-2019-127767

Published: 2019

Journal Articles

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Tanabe Mikoto, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MD PhD, Luis Espinoza, MD PhD, Kana Maruyama, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3874.

https://doi.org/10.1182/blood-2018-99-118741

Published: 2018

Journal Articles

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Mahmoud Ibrahim Elbadry, MD, Hiroki Mizumaki, MD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Kazuhisa Chonabayashi, MD PhD, Yoshinori Yoshida, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD PhD, Tatsuya Imi, MD, Nguyen Thi Mai Anh, MD, Yoichi Fujii, MD, Seishi Ogawa, MD PhD, Katsuto Takenaka, MD PhD, Koichi Akashi, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3855.

https://doi.org/10.1182/blood-2018-99-113756

Published: 2018

Journal Articles

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tanabe Mikoto, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MDPhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Fumihiro Azuma, Hiroyuki Kishi, PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 2584.

https://doi.org/10.1182/blood-2018-99-118541

Published: 2018

Journal Articles

Bystander Proliferation of Piga-M utated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes

Takeshi Yoroidaka, MD, Kohei Hosokawa, MD PhD, Tatsuya Imi, MD, Takamasa Katagiri, PhD, Fumihiro Azuma, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 1308.

https://doi.org/10.1182/blood-2018-99-115623

Published: 2018

Journal Articles

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

Lauren G. Banaszak, BS, Valentina Giudice, MD, Xin Zhao, MD PhD, Zhijie Wu, MD, Kohei Hosokawa, MD PhD, Keyvan Keyvanfar, BS, Danielle Townsley, MD, Sachiko Kajigaya, PhD, Neal S. Young

Blood (2016) 128 (22): 2704.

https://doi.org/10.1182/blood.V128.22.2704.2704

Published: 2016

Journal Articles

A Plasma microRNA Signature As a Biomarker for Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Marie J. Desierto, BS, Maria del Pilar Fernandez Ibanez, BS, Olga Rios, RN, Barbara Weinstein, RN, Phillip Scheinberg, MD, Danielle M. Townsley, MD, Neal S. Young, MD

Blood (2016) 128 (22): 728.

https://doi.org/10.1182/blood.V128.22.728.728

Published: 2016

Journal Articles

Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis

Noriharu Nakagawa, MD, Hiroyuki Maruyama, MD, Yoshitaka Zaimoku, MD, Kana Maruyama, MD, Chizuru Saito, MD, Takamasa Katagiri, PhD, Kohei Hosokawa, MD PhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 2418.

https://doi.org/10.1182/blood.V126.23.2418.2418

Published: 2015

Journal Articles

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Pawel Muranski, MD, Xingmin Feng, PhD, Keyvan Keyvanfar, BS, Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Jichun Chen, PhD, Sachiko Kajigaya, PhD, James G. Taylor, MD, Christopher S. Hourigan, MD PhD, John Barrett, MD, Neal S. Young, MD

Blood (2014) 124 (21): 2940.

https://doi.org/10.1182/blood.V124.21.2940.2940

Published: 2014

Journal Articles

Chronological Analysis of Clonal Evolution in Acquired Aplastic Anemia

Blood (2014) 124 (21): 253.

https://doi.org/10.1182/blood.V124.21.253.253

Published: 2014

Journal Articles

Spectrum Of Genetic Alterations In Acquired Aplastic Anemia

Tetsuichi Yoshizato, MD, Bogdan Dumitriu, MD, Kohei Hosokawa, MD, PhD, Hideki Makishima, MD, PhD, Kenichi Yoshida, MD, Yusuke Okuno, Kenichi Chiba, BA, Hiroko Tanaka, BA, Yuichi Shiraishi, PhD, Yasunobu Nagata, MD, Takamasa Katagiri, PhD, Ayana Kon, MD, Michael J. Clemente, Masashi Sanada, MD, Satoru Miyano, PhD, Jaroslaw P. Maciejewski, MD, PhD, Shinji Nakao, MD, PhD, Neal S. Young, MD, Seishi Ogawa, MD, PhD

Blood (2013) 122 (21): 2464.

https://doi.org/10.1182/blood.V122.21.2464.2464

Published: 2013

Journal Articles

Prevalence, Clone Size and Lineage Diversity Of HLA-A Allele-Lacking Leukocytes In Patients With Acquired Aplastic Anemia

Hiroyuki Maruyama, MD, Takamasa Katagiri, Ph.D., Yoshitaka Zaimoku, MD, Chizuru Saito, MD, Kohei Hosokawa, MD, PhD, Hirohito Yamazaki, MD, PhD, Seishi Ogawa, MD, PhD, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 2475.

https://doi.org/10.1182/blood.V122.21.2475.2475

Published: 2013

Journal Articles

Increased Gene Expression Of The Nr4A Family In Bone Marrow T Cells Of Patients With Early Stage Acquired Aplastic Anemia

Kohei Hosokawa, MD, PhD, Takumi Nishiuchi, PhD, Takamasa Katagiri, Ph.D., Chizuru Saito, MD, Hiroyuki Maruyama, MD, Naomi Sugimori, MD, PhD, Hirohito Yamazaki, MD, PhD, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 1238.

https://doi.org/10.1182/blood.V122.21.1238.1238

Published: 2013

Journal Articles

Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)

Naoshi Obara, MD, PhD, Shigeru Chiba, MD, PhD, Kohei Hosokawa, MD, PhD, Chiharu Sugimori, MD, PhD, Masaki Yamamoto, MD, Hideyoshi Noji, MD, PhD, Yuji Yonemura, MD, PhD, Yoshihiko Nakamura, MD, PhD, Kiyoshi Ando, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Tsutomu Shichishima, MD, PhD, Haruhiko Ninomiya, MD, PhD, Jun-ichi Nishimura, MD, PhD, Yuzuru Kanakura, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 1241.

https://doi.org/10.1182/blood.V122.21.1241.1241

Published: 2013

NARROW

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Bystander Proliferation of Piga-M utated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

A Plasma microRNA Signature As a Biomarker for Acquired Aplastic Anemia

Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Chronological Analysis of Clonal Evolution in Acquired Aplastic Anemia

Spectrum Of Genetic Alterations In Acquired Aplastic Anemia

Prevalence, Clone Size and Lineage Diversity Of HLA-A Allele-Lacking Leukocytes In Patients With Acquired Aplastic Anemia

Increased Gene Expression Of The Nr4A Family In Bone Marrow T Cells Of Patients With Early Stage Acquired Aplastic Anemia

Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)

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American Society of Hematology

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American Society of Hematology

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