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Journal Articles

Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-β2 As an Immunotherapeutic Target

Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, William C Temple, Bonell Patino Escobar, Maryna Gorelik, Christian Ihling, Matthew A Nix, Akul Naik, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D Leavitt, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine Smith, Robert L Moritz, Sachdeva S Sidhu, Lan Huang, Arun P Wiita
Journal: Blood
Blood (2022) 140 (Supplement 1): 867–868.
https://doi.org/10.1182/blood-2022-162697
Published: 2022
Journal Articles

A Bioinformatic Approach to the Clinical Evaluation of Linear Commitment Versus Cloud (Continuum of Low Primed UnDifferentiated) Models for Hematopoiesis Using Plinabulin Clinical Trial Data

Ramon W. Mohanlal, June Lu, Lan Huang, Lorna Honour, Douglas W. Blayney
Journal: Blood
Blood (2022) 140 (Supplement 1): 11165–11166.
https://doi.org/10.1182/blood-2022-167277
Published: 2022
Journal Articles

Prevention of Docetaxel (Doc)-Induced Neutropenia (DIN) with Single Agent Plinabulin (Plin) Versus (vs) Control (No-Treatment or Placebo) in Non-Small Cell Lung Cancer (NSCLC) in Two Randomized Trials

Douglas W. Blayney, Stephan Ogenstad, Gabrielle Legaspi, Stephen Duprez, Lan Huang, Ramon W. Mohanlal
Journal: Blood
Blood (2022) 140 (Supplement 1): 2610–2611.
https://doi.org/10.1182/blood-2022-166861
Published: 2022
Journal Articles

Plinabulin Rapidly (within 24 Hours) Reverses Myelosuppression Induced By Chemotherapy

Douglas W. Blayney, Mengru Chang, Lan Huang, Ramon Mohanlal
Journal: Blood
Blood (2021) 138 (Supplement 1): 2056.
https://doi.org/10.1182/blood-2021-150920
Published: 2021
Journal Articles

Protective-2 (BPI-2358-106): A Confirmatory Trial to Demonstrate Superiority of the Plinabulin+Pegfilgrastim (Plin/Peg) Combination Versus Standard of Care Pegfilgrastim for the Prevention of Chemotherapy-Induced Neutropenia (CIN) in Breast Cancer (BC) Patients (pts)

Douglas W. Blayney, MD, Ramon Mohanlal, PhD MD, Lan Huang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16.
https://doi.org/10.1182/blood-2020-141110
Published: 2020
Journal Articles

A Randomized Phase 3 Clinical Trial of the Combination of Plinabulin (plin) + Pegfilgrastim (peg) Versus (vs) Peg Alone for Tac (docetaxel, doxorubicin, cyclophosphamide) Induced Neutropenia (cin)

Douglas W. Blayney, MD, Lan Huang, PhD, Ramon Mohanlal, PhD MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3590.
https://doi.org/10.1182/blood-2019-127310
Published: 2019
Journal Articles

Clinical Evidence Against the Continuum of Low-Primed Uncommitted Hematopoietic and Progenitor Cells (CLOUD-HSPC) Concept for Hematopoiesis

Ramon Mohanlal, PhD MD, Douglas W. Blayney, MD, Lan Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4860.
https://doi.org/10.1182/blood-2019-128563
Published: 2019
Journal Articles

Clinical Evidence of Granulocyte-Monocyte Progenitor (GMP) Stem Cell Involvement in Plinabulin's Mechanism of Action (MoA) for the Prevention of Docetaxel (Doc) Chemotherapy (Chemo)-Induced Neutropenia (CIN)

Douglas W. Blayney, MD, Lan Huang, PhD, Ramon Mohanlal, PhD MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4861.
https://doi.org/10.1182/blood-2019-127227
Published: 2019
Journal Articles

Plinabulin, a Novel Small Molecule in Development for Chemotherapy-Induced-Neutropenia (CIN) Prevention, Mobilizes CD34+ Cells through a Mechanism of Action (MoA) Different from G-CSF and from CXCR4 Inhibition

Douglas W. Blayney, MD, Ene Ette, PhD, Stephan Ogenstad, PhD, Yuankai Shi, MD PhD, Lihua Du, Kenneth Lloyd, PhD, Lan Huang, PhD, Ramon Mohanlal, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2068.
https://doi.org/10.1182/blood-2018-99-113569
Published: 2018
Journal Articles

Plinabulin, a Novel Small Molecule That Ameliorates Chemotherapy-Induced Neutropenia, Is Administered on the Same Day of Chemotherapy and Has Anticancer Efficacy

Douglas W Blayney, MD, Lyudmila Bazhenova, MD, G. Kenneth Lloyd, PhD, Lan Huang, PhD, Ramon Mohanlal, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2508.
https://doi.org/10.1182/blood.V128.22.2508.2508
Published: 2016