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Laura Z. Rassenti, PhD
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Journal Articles

Genetic Determinants and Evolutionary History of Richter's Syndrome

Erin Michelle Parry, MD PhD, Romain Guieze, MD, Ignaty Leshchiner, PhD, Daniel Rosebrock, Bria Persaud, Camilla K Lemvigh, MSc, Eugen Tausch, MD, Matthew S. Davids, MD, Johannes Bloehdorn, MD, Christof Schneider, MD, Liudmila Elagina, Aina Zurita Martinez, Amaro Taylor-Weiner, PhD, Nitin Jain, MD, William G. Wierda, MD PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Julien Broséus, Florence Cymbalista, MD PhD, Neil E. Kay, MD, Kenneth J. Livak, PhD, Shuqiang Li, PhD, Teddy Huang, BS, Noelia Purroy, MD PhD, Annabelle J Anandappa, MD, Stacey M. Fernandes, BS, Filippo Utro, PhD, Kahn Rhrissorrakrai, PhD, Chaya Levovitz, MD PhD, Brian P Danysh, PhD, Kara Slowik, Sameer A. Parikh, MD, Jennifer R Brown, MD PhD, Laxmi Parida, PhD, Donna S. Neuberg, ScD, Stephan Stilgenbauer, MD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-139456
Published: 2020
Journal Articles

IKZF3 Overexpression Phenocopies Gain-of-Function Mutation in Chronic Lymphocytic Leukemia

Shanye Yin, PhD, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Satyen Gohil, BSc, MBBS, MRCP, FRCPath, Shuqiang Li, PhD, Laura Z. Rassenti, PhD, Leah Billington, BA, Elizabeth Witten, Teddy Huang, BS, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Fanny Baran-Marszak, MD PhD, Thomas J. Kipps, MD PhD, Florence Cymbalista, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9.
https://doi.org/10.1182/blood-2020-137085
Published: 2020
Journal Articles

Expression of Sf3b1-K700E accelerates the Development of Chronic Lymphocytic Leukemia in a Del (13q) Murine Model

Bo Zhang, MDPhD, Prajish Iyer, PhD, Meiling Jin, PhD, Elisa Ten Hacken, PhD, Zachary Cartun, BS, Kevyn Hart, BS, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD, Lili Wang, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-139096
Published: 2020
Journal Articles

The CLL-1100 Project: Towards Complete Genomic Characterization and Improved Prognostics for CLL

Binyamin A. Knisbacher, PhD, Ziao Lin, BS, Cynthia K. Hahn, MD PhD, Ferran Nadeu, Martí Duran-Ferrer, Kristen E. Stevenson, MS, Eugen Tausch, MD, Alex Barbera-Mourelle, Andrew Dunford, Shankara Anand, Julio Delgado, MD, Julian M. Hess, Amaro Taylor-Weiner, PhD, Helene Kretzmer, PhD, Pablo Bousquets Muñoz, Conner J. Shaughnessy, Stacey M. Fernandes, BS, Mariela Sivina, Laura Z. Rassenti, PhD, Alexander Meissner, PhD, Adrian Wiestner, MD PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD PhD, Jennifer R Brown, MD PhD, Michael Hallek, François Aguet, PhD, Donna S. Neuberg, ScD, Xose S Puente, PhD, Chip Stewart, PhD, José I. Martín-Subero, PhD, Stephan Stilgenbauer, MD, Catherine J. Wu, MD, Elías Campo, MD PhD, Gad Getz, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-140987
Published: 2020
Journal Articles

High-Level ROR1 and BCL2, Cancer-Stemness, and BCL2 Mutations Associate with Venetoclax Resistance in Chronic Lymphocytic Leukemia

Emanuela M. Ghia, PhD, Laura Z. Rassenti, PhD, Michael Y. Choi, MD, Elvin Chu, George F. Widhopf II, PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 476.
https://doi.org/10.1182/blood-2019-131426
Published: 2019
Journal Articles

Cirmtuzumab, a ROR1 Targeted Mab, Reverses Cancer Stemness, and Its Combination with Ibrutinib Is Safe and Effective: Planned Analysis of the Cirll Phase 1/2 Trial for CLL and MCL

Michael Y. Choi, MD, Emanuela M. Ghia, PhD, Tanya Siddiqi, MD, William G. Wierda, MD PhD, Hun Ju Lee, Jacqueline C. Barrientos, MD MS, Nicole Lamanna, MD, Alec Goldenberg, Dimitrios Tzachanis, MD PhD, Erin G. Reid, MD MS, Elizabeth K Weihe, MD, Laura Z. Rassenti, PhD, Iris Isufi, MD, Stewart Bieler, BA, Xen Ianopulos, MD PhD, James B. Breitmeyer, MD PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1755.
https://doi.org/10.1182/blood-2019-131498
Published: 2019
Journal Articles

Wnt5a Induces ROR1-Dependent Upregulation of MMP9 and Enhanced Invasiveness in Chronic Lymphocytic Leukemia

Md Kamrul Hasan, PhD, Laura Z. Rassenti, PhD, George F. Widhopf II, PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4274.
https://doi.org/10.1182/blood-2019-131600
Published: 2019
Journal Articles

Identification of Genotype-Specific Therapeutic Vulnerabilities By Comparative Dynamic BH3 Profiling Analysis of Human and Murine CLL

Shanye Yin, PhD, Salma Parvin, PhD, Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Heather Joyal, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Thomas J. Kipps, MD PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Matthew S. Davids, MD, Ruben D. Carrasco, MD PhD, Anthony G. Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4281.
https://doi.org/10.1182/blood-2019-127293
Published: 2019
Journal Articles

Tecfidera Modulates Activation of Malignant B-Cells: Correlative Analysis from a Phase 1 Clinical Trial in Patients with Chronic Lymphocytic Leukemia

Christina Wu, PhD, Emanuela M. Ghia, PhD, Fitzgerald Lao, Minya Pu, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Dennis A. Carson, MD, Michael Y. Choi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3143.
https://doi.org/10.1182/blood-2018-99-119292
Published: 2018
Journal Articles

Cirmtuzumab Inhibits Non-Canonical Wnt Signaling without Enhancing Canonical Wnt/β-Catenin Signaling in Chronic Lymphocytic Leukemia

Han Zhang, PhD, Suping Zhang, PhD, Emanuela M. Ghia, PhD, Michael Y. Choi, MD, Jieyu Zhang, MS, Liguang Chen, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2652.
https://doi.org/10.1182/blood-2018-99-119606
Published: 2018
Journal Articles

Recurrent Mutations in EGR2 Direct Specific Epigenetic Reconfiguration in Chronic Lymphocytic Leukemia

Christoph Weigel, PhD, Yassen Assenov, Charles Imbusch, Qi Wang, Renée Beekman, Brian Giacopelli, BS, Yue-zhong Wu, MSc, David Brocks, Weichenhan Dieter, Popanda Odilia, Peter Schmezer, Benedikt Brors, Daniel Mertens, Karsten Rippe, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Jennifer A. Woyach, MD, James S. Blachly, MD, Elias Campo, Thorsten Zenz, MD, John C. Byrd, MD, José I. Martin-Subero, PhD, Christoph Plass, Christopher C. Oakes
Journal: Blood
Blood (2018) 132 (Supplement 1): 650.
https://doi.org/10.1182/blood-2018-99-119070
Published: 2018
Journal Articles

Wnt5a Induces ROR1 Dependent Tyrosine Phosphorylation of DOCK2, and Enhanced Activation of ERK to Promote Proliferation of CLL Cells

Thomas Kipps, MD, Laura Z. Rassenti, PhD, George F. Widhopf II, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4404.
https://doi.org/10.1182/blood-2018-99-117175
Published: 2018
Journal Articles

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Michael Y. Choi, MD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Emanuela M. Ghia, PhD, Elsa Sanchez-Lopez, PhD, George F. Widhopf II, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4415.
https://doi.org/10.1182/blood-2018-99-111996
Published: 2018
Journal Articles

Single Cell Transcriptomic Characterization of the Immune Microenvironment in Naturally Progressing Chronic Lymphocytic Leukemia (CLL)

Noelia Purroy, MD PhD, Jean Fan, PhD, Shuqiang Li, Laura Z. Rassenti, PhD, James A Lederer, PhD, Donna S Neuberg, ScD, Thomas J. Kipps, MD PhD, Peter Kharchenko, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3112.
https://doi.org/10.1182/blood-2018-99-110931
Published: 2018
Journal Articles

ROR1 Expression Is Associated with Oncogenic Dedifferentiation in Chronic Lymphocytic Leukemia

Emanuela M. Ghia, PhD, Michael Y. Choi, MD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1853.
https://doi.org/10.1182/blood-2018-99-119711
Published: 2018
Journal Articles

Development of Cirmtuzumab Antibody-Drug Conjugates (ADCs) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1)

Yousaf A. Mian, PhD, George F. Widhopf II, PhD, Thanh-Trang Vo, PhD, Katti Jessen, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1862.
https://doi.org/10.1182/blood-2018-99-119447
Published: 2018
Journal Articles

Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1

Elsa Sanchez-Lopez, PhD, Emanuela M. Ghia, PhD, Laura Antonucci, PhD, Laura Z. Rassenti, PhD, Yun Chen, PhD, Thomas J. Kipps, MD PhD, Michael Karin, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3122.
https://doi.org/10.1182/blood-2018-99-115564
Published: 2018
Journal Articles

B-Cell Receptor Signaling Drives Glycolysis in Chronic Lymphocytic Leukemia Cells

Andrew James Clear, BSc, Annalisa D'Avola, PhD, Samir G. Agrawal, BSc, PhD MBChB, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, John G. Gribben, John Riches, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3121.
https://doi.org/10.1182/blood-2018-99-112860
Published: 2018
Journal Articles

Wnt5a Induces Association of ROR1 with Ca 2+ /Calmodulin-Dependent Protein Kinase II and ROR1-Dependent Calcium Influx in Chronic Lymphocytic Leukemia

Liguang Chen, PhD, Yun Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1846.
https://doi.org/10.1182/blood-2018-99-119811
Published: 2018
Journal Articles

Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway

Jian Yu, PhD, Yun Chen, PhD, Liguang Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf II, PhD, Thomas J. Kipps, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4019.
https://doi.org/10.1182/blood.V130.Suppl_1.4019.4019
Published: 2017