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Journal Articles

Concomitant Suppression of IKZF1, IRF4 and MYC Contribute to the Anti-Tumor Activity of the BET Inhibitor, Cpi-0610, in Disease Models of Multiple Myeloma

Ka Tat Siu, PhD, Janani Ramachandran, MA, Andrew J. Yee, MD, Homare Eda, MD PhD, Loredana Santo, MD, Elizabeth K. O'Donnell, MD, Cristina Panaroni, PhD, Jennifer Mertz, PhD, Robert J. Sims, PhD, Michael Cooper, MD, Noopur Raje, MD

Blood (2016) 128 (22): 3320.

https://doi.org/10.1182/blood.V128.22.3320.3320

Published: 2016

Journal Articles

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

Hiroto Ohguchi, MD PhD, Teru Hideshima, MDPhD, Manoj Bhasin, PhD, Gullu Gorgun, PhD, Loredana Santo, MD, Michele Cea, MD, Naoya Mimura, MD PhD, Rikio Suzuki, MDPhD, Yu-Tzu Tai, PhD, Ruben D. Carrasco, MD PhD, Noopur S. Raje, MD, Paul G. Richardson, MD, Hideo Harigae, MD PhD, Takaomi Sanda, MD PhD, Kenneth C. Anderson, MD

Blood (2015) 126 (23): 3633.

https://doi.org/10.1182/blood.V126.23.3633.3633

Published: 2015

Journal Articles

Effect of the BET Inhibitor, Cpi-0610, Alone and in Combination with Lenalidomide in Multiple Myeloma

Ka Tat Siu, PhD, Homare Eda, MDPhD, Loredana Santo, MD, Janani Ramachandran, MA, Miroslav Koulnis, PhD, Jennifer Mertz, PhD, Robert J. Sims, PhD, Michael Cooper, MD, Noopur S. Raje, MD

Blood (2015) 126 (23): 4255.

https://doi.org/10.1182/blood.V126.23.4255.4255

Published: 2015

Journal Articles

Novel In Vivo Model of Multiple Myeloma Bone Disease Using ß-Tricalcium Phosphate Artificial Bone Grafts

Miroslav Koulnis, PhD, Homare Eda, MDPhD, Loredana Santo, MD, Ka Tat Siu, PhD, Janani Ramachandran, MA, Cristina Panaroni, PhD, Takaaki Tanaka, MD PhD, Noopur S. Raje, MD

Blood (2015) 126 (23): 4200.

https://doi.org/10.1182/blood.V126.23.4200.4200

Published: 2015

Journal Articles

The Biologic Relevance of PIM Kinases in the Context of Multiple Myeloma and Their Potential As Therapeutic Targets in Combination Drug Therapy

Janani Ramachandran, MA, Loredana Santo, MD, Homare Eda, MDPhD, Dharminder Chauhan, PhD, Ka Tat Siu, PhD, Miroslav Koulnis, PhD, Dennis Huszar, PhD, Kenneth C Anderson, MD, Noopur S. Raje, MD

Blood (2015) 126 (23): 2992.

https://doi.org/10.1182/blood.V126.23.2992.2992

Published: 2015

Journal Articles

Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Noopur S. Raje, MD, Naoya Mimura, MD, PhD, James E. Bradner, MD, Diana Cirstea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Michael Sellitto, Yiguo Hu, PhD, Claire Fabre, MD, PhD, Hiroto Ohguchi, MD, PhD, Jiro Minami, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2011) 118 (21): 128.

https://doi.org/10.1182/blood.V118.21.128.128

Published: 2011

Journal Articles

Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma

Blood (2011) 118 (21): 133.

https://doi.org/10.1182/blood.V118.21.133.133

Published: 2011

Journal Articles

Selective HDAC6 Inhibition Via ACY-1215, Either Alone or in Combination with Bortezomib, Restores Osteoblast Function and Suppresses Osteoclast Differentiation in Multiple Myeloma

Loredana Santo, MD, Teru Hideshima, MD, PhD, Andrew L. Kung, MD, PhD, Jen-Chieh Tseng, PhD, David Tamang, PhD, Min Yang, PhD, Matthew Jarpe, PhD, John H. van Duzer, PhD, Ralph Mazitschek, PhD, Diana Cirstea, MD, Homare Eda, MD, PhD, Tyler A. Scullen, BA, Scott Rodig, MD, PhD, Miriam Canavese, PhD, James Bradner, MD, Kenneth C Anderson, MD, Simon Jones, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2908.

https://doi.org/10.1182/blood.V118.21.2908.2908

Published: 2011

Journal Articles

Pharmacodynamic and Pharmacokinetic Properties of a Novel and Selective HDAC6 Inhibitor, ACY-1215, in Combination with Bortezomib in Multiple Myeloma

Loredana Santo, MD, Teru Hideshima, MD, PhD, Andrew L. Kung, MD, PhD, Jen-Chieh Tseng, PhD, David Tamang, PhD, Min Yang, PhD, Matthew Jarpe, PhD, John H. van Duzer, PhD, Ralph Mazitschek, PhD, Walter C Ogier, Diana D. Cirstea, MD, Scott Rodig, MD, PhD, Homare Eda, MD, PhD, Tyler A. Scullen, BA, Miriam Canavese, PhD, James E. Bradner, MD, Kenneth C Anderson, MD, Simon Jones, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2912.

https://doi.org/10.1182/blood.V118.21.2912.2912

Published: 2011

Journal Articles

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

Diana Cirstea, MD, Teru Hideshima, MD, PhD, Loredana Santo, MD, Homare Eda, MD, PhD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Anuj K. Mahindra, MD, Gullu Gorgun, PhD, Yiguo Hu, MD, PhD, Naoya Mimura, MD, PhD, Claire Fabre, MD, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Kenneth C. Anderson, MD, Sylvie M Guichard, PharmD, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2916.

https://doi.org/10.1182/blood.V118.21.2916.2916

Published: 2011

Journal Articles

Targeting Bruton's Tyrosine Kinase As a Novel Approach to Inhibit Osteoclast Function in Multiple Myeloma

Homare Eda, MD, PhD, Loredana Santo, MD, Diana D. Cirstea, MD, Samantha Pozzi, MD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Sonia Vallet, MD, Erica Evans, PhD, Juswinder Singh, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2882.

https://doi.org/10.1182/blood.V118.21.2882.2882

Published: 2011

Journal Articles

Increased Sclerostin Secretion in Multiple Myeloma Results in Stimulation of Osteoclastogenesis and Inhibition of Osteoblastogenesis

Homare Eda, MD, PhD, Loredana Santo, MD, Diana D. Cirstea, MD, Samantha Pozzi, MD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Sonia Vallet, MD, Noopur S. Raje, MD

Blood (2011) 118 (21): 1819.

https://doi.org/10.1182/blood.V118.21.1819.1819

Published: 2011

Journal Articles

Lenalidomide In Combination with the Activin Receptor Type II Murine Fc Protein RAP-011: Preclinical Rationale for a Novel Anti-Myeloma Strategy

Sonia Vallet, MD, Kishan Patel, Diana Cirstea, MD, Katie Luly, Samantha Pozzi, MD, Loredana Santo, MD, Homare Eda, MD, Jasbir Seehra, Anuj Mahindra, MD, David T. Scadden, MD, Noopur Raje, MD

Blood (2010) 116 (21): 4075.

https://doi.org/10.1182/blood.V116.21.4075.4075

Published: 2010

Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

Loredana Santo, MD, Teru Hideshima, MD, PhD, Diana Cirstea, MD, Madhavi L Bandi, PhD, Erik A Nelson, PhD, Hiroshi Ikeda, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Gullu Gorgun, PhD, Naoya Mimura, MD, Claire Fabre, MD, Yiguo Hu, PhD, Dharminder Chauhan, PhD, Matthew S Squires, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2010) 116 (21): 2994.

https://doi.org/10.1182/blood.V116.21.2994.2994

Published: 2010

Journal Articles

Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Naoya Mimura, MD, PhD, Diana Cirstea, M.D., Loredana Santo, MD, Yiguo Hu, MD, PhD, Claire Fabre, MD, Noopur Raje, MD, Nikhil C. Munshi, MD, Paul G Richardson, MD, Kenneth C. Anderson, MD

Blood (2010) 116 (21): 2996.

https://doi.org/10.1182/blood.V116.21.2996.2996

Published: 2010

Journal Articles

Selective Inhibition of HDAC6 with a New Prototype Inhibitor (ACY-1215) Overcomes Bortezomib Resistance In Multiple Myeloma (MM)

Loredana Santo, MD, Teru Hideshima, MD, PhD, Andrew L. Kung, MD, PhD, Matthew Jarpe, PhD, Diana Cirstea, M.D., Kishan Patel, Samantha Pozzi, MD, Jen C. Tseng, PhD, Scott J Rodig, James Bradner, M.D., Kenneth C. Anderson, MD, Simon Jones, PhD, Noopur Raje, MD

Blood (2010) 116 (21): 2997.

https://doi.org/10.1182/blood.V116.21.2997.2997

Published: 2010

Journal Articles

CYC065, a Potent Derivative of Seliciclib Is Active In Multiple Myeloma In Preclinical Studies

Samantha Pozzi, MD, Diana Cirstea, M.D., Loredana Santo, MD, Doris M Nabikejje, Kishan Patel, Kathryn M Luly, Gaurav Gharti-Chhetry, Sonia Vallet, MD, Homare Eda, MD, PhD, Teru Hideshima, MD, Simon R Green, Kenneth C. Anderson, MD, David T. Scadden, MD, Noopur Raje, MD

Blood (2010) 116 (21): 2999.

https://doi.org/10.1182/blood.V116.21.2999.2999

Published: 2010

Journal Articles

Molecular Profiling of Extramedullary and Medullary Plasmacytomas.

Anuj Mahindra, MD, Samir B Amin, MBBS, Gabriela Motyckova, MD, PhD, Aliyah R. Sohani, MD, Kishan Patel, Sonia Vallet, MD., Gaurav Chetri, Adam Ackerman, Samantha Pozzi, MD, Loredana Santo, MD, Diana Cirstea, MD, Christiana E. Toomey, Ephraim P. Hochberg, MD, Paola Dal Cin, Teru Hideshima, MD, PhD, Kenneth C. Anderson, MD, Nikhil Munshi, Noopur Raje, MD

Blood (2009) 114 (22): 1806.

https://doi.org/10.1182/blood.V114.22.1806.1806

Published: 2009

Journal Articles

CCL3 Impairs Osteoblast Function Via Downregulation of Osteocalcin.

Sonia Vallet, MD., Kishan Patel, Nileshwari Vaghela, Mariateresa Fulciniti, PhD, Petter Veiby, Teru Hideshima, M.D., Ph.D., Samantha Pozzi, MD, Loredana Santo, MD, Siddhartha Mukherjee, M.D., Diana Cirstea, MD, David T Scadden, MD, Kenneth C. Anderson, MD, Noopur Raje, MD.

Blood (2009) 114 (22): 739.

https://doi.org/10.1182/blood.V114.22.739.739

Published: 2009

Journal Articles

Immunomodulatory EFFECTS of Lenalidomide and Pomalidomide ON INTERACTION of TUMOR and BONE MARROW Accessory CELLS IN MULTIPLE MYELOMA.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Teru Hideshima, MD, PhD, Giulia Perrone, MD, Giada Bianchi, MD, Hiroshi Ikeda, MD, PhD, Mala Mani, PhD, Yiguo Hu, MD, PhD, Diana Cristea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Nikhil Munshi, MD, Paul Richardson, MD, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 950.

https://doi.org/10.1182/blood.V114.22.950.950

Published: 2009

NARROW

Concomitant Suppression of IKZF1, IRF4 and MYC Contribute to the Anti-Tumor Activity of the BET Inhibitor, Cpi-0610, in Disease Models of Multiple Myeloma

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

Effect of the BET Inhibitor, Cpi-0610, Alone and in Combination with Lenalidomide in Multiple Myeloma

Novel In Vivo Model of Multiple Myeloma Bone Disease Using ß-Tricalcium Phosphate Artificial Bone Grafts

The Biologic Relevance of PIM Kinases in the Context of Multiple Myeloma and Their Potential As Therapeutic Targets in Combination Drug Therapy

Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma

Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma

Selective HDAC6 Inhibition Via ACY-1215, Either Alone or in Combination with Bortezomib, Restores Osteoblast Function and Suppresses Osteoclast Differentiation in Multiple Myeloma

Pharmacodynamic and Pharmacokinetic Properties of a Novel and Selective HDAC6 Inhibitor, ACY-1215, in Combination with Bortezomib in Multiple Myeloma

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

Targeting Bruton's Tyrosine Kinase As a Novel Approach to Inhibit Osteoclast Function in Multiple Myeloma

Increased Sclerostin Secretion in Multiple Myeloma Results in Stimulation of Osteoclastogenesis and Inhibition of Osteoblastogenesis

Lenalidomide In Combination with the Activin Receptor Type II Murine Fc Protein RAP-011: Preclinical Rationale for a Novel Anti-Myeloma Strategy

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma

Selective Inhibition of HDAC6 with a New Prototype Inhibitor (ACY-1215) Overcomes Bortezomib Resistance In Multiple Myeloma (MM)

CYC065, a Potent Derivative of Seliciclib Is Active In Multiple Myeloma In Preclinical Studies

Molecular Profiling of Extramedullary and Medullary Plasmacytomas.

CCL3 Impairs Osteoblast Function Via Downregulation of Osteocalcin.

Immunomodulatory EFFECTS of Lenalidomide and Pomalidomide ON INTERACTION of TUMOR and BONE MARROW Accessory CELLS IN MULTIPLE MYELOMA.

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American Society of Hematology

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American Society of Hematology

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