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Jasbir Seehra
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Journal Articles

Rker-216 Reversed Microcytic Anemia in a Mouse Model of Iron Refractory Iron Deficiency Anemia

Chia-Yu Wang, Emiliano Melgar-Bermudez, Diana Welch, Samuel Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2023) 142 (Supplement 1): 2466.
https://doi.org/10.1182/blood-2023-179253
Published: 2023
Journal Articles

Rker-050, a Modified Activin Receptor Type Iia Ligand Trap, Promoted Erythropoiesis in a Murine Model of Myelofibrosis

Blake Moses, Mike Dills, Ashlyn Wheeler, Radina Todorova, Savanna Macaluso, Tyler Damen, Samuel Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2023) 142 (Supplement 1): 4524.
https://doi.org/10.1182/blood-2023-178741
Published: 2023
Journal Articles

Rker-050, a Novel Activin Receptor Type II Ligand Trap, Rescued Anemia and Reduced Bone Loss in a Mouse Model of Myelodysplastic Syndromes

Blake S Moses, Chris Materna, Remya Nathan, Tandicka Nurse, Keith Babbs, Claire Tseng, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 9763–9764.
https://doi.org/10.1182/blood-2022-169360
Published: 2022
Journal Articles

ALK2 Inhibition and a Modified Activin Receptor Type Iia Ligand Trap Cotherapy Maximized Hematologic Improvements in a Mouse Model of Anemia of Inflammation

Chia-Yu Wang, Emiliano Melgar-Bermudez, Diana Welch, Claire C Tseng, Ffolliott Fisher, Samuel M Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 5337–5338.
https://doi.org/10.1182/blood-2022-166838
Published: 2022
Journal Articles

A Monoclonal Antibody Targeting ALK2 As a Potential Therapeutic Agent for Anemia of Inflammation

Natalia Medeiros, Thomas A Backus, Christopher Materna, Ffolliott Fisher, Jenn Lachey, Jasbir Seehra
Journal: Blood
Blood (2021) 138 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2021-153160
Published: 2021
Journal Articles

Rker-050 Rescued Ruxolitinib (Rux)-Associated Reductions in Red Blood Cell Volume

Remya Nathan, Marina Feigenson, Joshua Lamora, Claire C Tseng, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 934.
https://doi.org/10.1182/blood-2021-152729
Published: 2021
Journal Articles

Ker-050, an Inhibitor of TGF- β Superfamily Signaling, Promoted Thrombopoiesis and Reversed Immune Thrombocytopenia in a Mouse Model of Disease

Marina Feigenson, Remya Nathan, Joshua Lamora, Ffolliott Fisher, Claire C Tseng, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 2068.
https://doi.org/10.1182/blood-2021-152814
Published: 2021
Journal Articles

Ker-050, a Novel Inhibitor of Tgfβ Superfamily Signaling, Induces Red Blood Cell Production By Promoting Multiple Stages of Erythroid Differentiation

Marina Feigenson, PhD, Remya Nathan, Christopher Materna, Alana Gudelsky, Evan Lema, Claire C Tseng, PhD, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-140364
Published: 2020
Journal Articles

Ker-050, a Modified Actriia Ligand Trap, Alleviates Cytopenia Arising from Multiple Etiologies

Marina Feigenson, PhD, Remya Nathan, Keith Babbs, Christopher Materna, Claire C Tseng, PhD, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2020) 136 (Supplement 1): 38.
https://doi.org/10.1182/blood-2020-140167
Published: 2020
Journal Articles

Administration of KER-047, a Novel ALK2 Inhibitor, Elicited Robust and Sustained Increases in Serum Iron in Healthy Participants

Claudia Ordonez, MD, Snyder Ben, MD, Rachel Barger, Timna Serino, Claire C Tseng, PhD, Christopher Rovaldi, M.Sc, Jenn Lachey, Jasbir Seehra
Journal: Blood
Blood (2020) 136 (Supplement 1): 13.
https://doi.org/10.1182/blood-2020-140323
Published: 2020
Journal Articles

Selective Inhibition of ALK2 Signaling Suppresses Serum Hepcidin and Increases Serum Iron

Thomas A Backus, Natalia Medeiros, Evan Lema, Ffolliott Fisher, Jasbir Seehra, Jennifer Lachey
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-139486
Published: 2020
Journal Articles

ACE-536, a Modified Type II Activin Receptor Increases Red Blood Cells In Vivo by Promoting Maturation of Late Stage Erythroblasts

Rajasekhar NVS Suragani, Samuel M. Cadena, Dianne Mitchell, Dianne Sako, Monique Davies, Kathleen Tomkinson, Mathew Devine, Jeff Ucran, Asya Grinberg, Kathryn Underwood, R. Scott Pearsall, Jasbir Seehra, Ravindra Kumar
Journal: Blood
Blood (2010) 116 (21): 4236.
https://doi.org/10.1182/blood.V116.21.4236.4236
Published: 2010
Journal Articles

Lenalidomide In Combination with the Activin Receptor Type II Murine Fc Protein RAP-011: Preclinical Rationale for a Novel Anti-Myeloma Strategy

Sonia Vallet, MD, Kishan Patel, Diana Cirstea, MD, Katie Luly, Samantha Pozzi, MD, Loredana Santo, MD, Homare Eda, MD, Jasbir Seehra, Anuj Mahindra, MD, David T. Scadden, MD, Noopur Raje, MD
Journal: Blood
Blood (2010) 116 (21): 4075.
https://doi.org/10.1182/blood.V116.21.4075.4075
Published: 2010
Journal Articles

Molecular Sequaele of Activin A-Dependent Osteoblast Inhibition in Myeloma.

Sonia Vallet, MD., Siddhartha Mukherjee, M.D., Nileshwari Vaghela, Teru Hideshima, M.D., Ph.D., Mariateresa Fulciniti, PhD, Samantha Pozzi, MD, Loredana Santo, Diana Cirstea, MD, Aliyah Rahemtullah, MD, Eyal C. Attar, MD, Alexander R Guimaraes, Dharminder Chauhan, Ph.D, Wanling Xie, Chirayu Patel, Jesse Schoonmaker, Michael Churchill, Kishan Patel, Edie Weller, PhD, Nikhil C. Munshi, Jasbir Seehra, Kenneth C. Anderson, MD, David T. Scadden, MD, Noopur Raje, MD.
Journal: Blood
Blood (2009) 114 (22): 1789.
https://doi.org/10.1182/blood.V114.22.1789.1789
Published: 2009