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R. Scott Pearsall
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Journal Articles

Modified Actriib-Fc Fusion Protein (ACE-536) Mitigates Sickling and Red Cell Pathology in a Murine Model of Sickle Cell Disease

Rajasekhar NVS Suragani, PhD, Robert Li, Sharon M Cawley, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2014) 124 (21): 4055.
https://doi.org/10.1182/blood.V124.21.4055.4055
Published: 2014
Journal Articles

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Rajasekhar N. V. S. Suragani, Sharon M. Cawley, Robert Li, Samantha Wallner, Mark J. Alexander, Aaron W. Mulivor, Sara Gardenghi, Stefano Rivella, Asya V. Grinberg, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2014) 123 (25): 3864–3872.
https://doi.org/10.1182/blood-2013-06-511238
Published: 2014
Includes: Supplemental data
Journal Articles

Modified Activin Receptor Type IIb-Fc Fusion Protein (RAP-536) Decreases Anemia In a Murine Model Of Myelodysplastic Syndrome and Improves Overall Survival

Rajasekhar NVS Suragani, PhD, Robert Li, Sharon Cawley, R. Scott Pearsall, Ph.D., Ravi Kumar, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 749.
https://doi.org/10.1182/blood.V122.21.749.749
Published: 2013
Journal Articles

RAP-536 Promotes Terminal Erythroid Differentiation and Reduces Anemia in a Murine Model of Myelodysplastic Syndromes

Rajasekhar NVS Suragani, Robert Li, Dianne Sako, Asya Grinberg, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2012) 120 (21): 3796.
https://doi.org/10.1182/blood.V120.21.3796.3796
Published: 2012
Journal Articles

ACE-536 Improves Ineffective Erythropoiesis, Anemia and Co-Morbidities in β-Thalassemia

Rajasekhar NVS Suragani, Robert Li, Sharon Cawley, Stefano Rivella, PhD, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2012) 120 (21): 248.
https://doi.org/10.1182/blood.V120.21.248.248
Published: 2012
Journal Articles

RAP-536 Promotes Terminal Erythroid Differentiation and Reduces Anemia in Myelodysplastic Syndromes

Rajasekhar NVS Suragani, Aaron Mulivor, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2011) 118 (21): 610.
https://doi.org/10.1182/blood.V118.21.610.610
Published: 2011
Journal Articles

RAP-536, A Soluble Activin Receptor Type IIb Murine IgG-Fc Fusion Protein, Prevents Myelodysplastic Syndrome Related Anemia

Aaron Mulivor, Samuel M. Cadena, Rajasekhar NVS Suragani, Ravindra Kumar, Kathryn Underwood, Jas Seehra, R. Scott Pearsall
Journal: Blood
Blood (2010) 116 (21): 978.
https://doi.org/10.1182/blood.V116.21.978.978
Published: 2010
Journal Articles

RAP-536 Accelerates Recovery From Chemotherapy-Induced Anemia (CIA) without Promoting Tumor Growth In Murine Models of Cancer and CIA

Samuel M. Cadena, Rajasekhar NVS Suragani, Dianne Mitchell, Jeff Ucran, Katia Liharska, Dianne Sako, Travis Monnell, Kathryn Underwood, Ravindra Kumar, R. Scott Pearsall
Journal: Blood
Blood (2010) 116 (21): 4230.
https://doi.org/10.1182/blood.V116.21.4230.4230
Published: 2010
Journal Articles

ACE-536, a Modified Type II Activin Receptor Increases Red Blood Cells In Vivo by Promoting Maturation of Late Stage Erythroblasts

Rajasekhar NVS Suragani, Samuel M. Cadena, Dianne Mitchell, Dianne Sako, Monique Davies, Kathleen Tomkinson, Mathew Devine, Jeff Ucran, Asya Grinberg, Kathryn Underwood, R. Scott Pearsall, Jasbir Seehra, Ravindra Kumar
Journal: Blood
Blood (2010) 116 (21): 4236.
https://doi.org/10.1182/blood.V116.21.4236.4236
Published: 2010
Journal Articles

RAP-011, a Soluble Activin Receptor Type IIa Murine IgG-Fc Fusion Protein, Prevents Chemotherapy Induced Anemia.

Aaron W Mulivor, Ph.D., Denise Barbosa, Ravi Kumar, Ph.D., Matthew Leigh Sherman, MD, Jas Seehra, R. Scott Pearsall, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 161.
https://doi.org/10.1182/blood.V114.22.161.161
Published: 2009
Journal Articles

ACE-536, a Novel, GDF-Trap, Promotes Rapid Increase of Red Blood Cells In Vivo in An EPO-Independent Manner.

Dianne Mitchell, Samuel Cadena, Chris Rogers, June Liu, Kathleen Tomkinson, Joe Barberio, Asya Grinberg, Kathryn W. Underwood, R. Scott Pearsall, Ravindra Kumar
Journal: Blood
Blood (2009) 114 (22): 2505.
https://doi.org/10.1182/blood.V114.22.2505.2505
Published: 2009
Journal Articles

ACE-536, a Novel GDF-Trap, Increases Hemoglobin, Hematocrit, and Red Blood Cell Levels in Rats and Monkeys.

Kenneth Loveday, Ph.D, Doriana Froim, Ph.D, Anna Pisania, Ph.D., Alissa Fernald, Mathew Spaits, R. Scott Pearsall, Ph.D., Ravi Kumar, Ph.D., Kathryn W. Underwood, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 3603.
https://doi.org/10.1182/blood.V114.22.3603.3603
Published: 2009
Journal Articles

Administration of a Novel GDF Trap Prevents Anemia Induced by Renal Insufficiency and Augments Recovery From Blood Loss.

Samuel M. Cadena, Dianne Mitchell, Jeff Ucran, Katia Liharska, Dianne Sako, Travis Monnell, Ravindra Kumar, Kathryn W. Underwood, R. Scott Pearsall, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 4037.
https://doi.org/10.1182/blood.V114.22.4037.4037
Published: 2009