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Journal Articles

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Ayiesha Barnes, MS, Ann Rux, Serge Yarovoi, Sooho S Myoung, Alexandra Johnson, Grace M Lee, MD, Madelaine Duarte, BA, Mortimer Poncz, MD, Gowthami M. Arepally, MD, Douglas B. Cines, MD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-138631

Published: 2020

Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 10.

https://doi.org/10.1182/blood-2019-123132

Published: 2019

Journal Articles

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Amrita Sarkar, PhD, Gowthami Arepally, MD, M. Anna Kowalska, PhD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Kandace Gollomp, MD

Blood (2018) 132 (Supplement 1): 271.

https://doi.org/10.1182/blood-2018-99-111381

Published: 2018

Journal Articles

Inhibition of Neutrophil Extracellular Trap Release through the Disruption of PAD4 Leads to Decreased Neutrophil and Platelet Accumulation at Sites of Venular Vascular Injury in a Murine Model of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Vincent Hayes, Ian Johnston, BS, Minna Kim, Guohua Zhao, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 2268.

https://doi.org/10.1182/blood.V130.Suppl_1.2268.2268

Published: 2017

Journal Articles

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Michael Frank, MD, Douglas B. Cines, MD, Gowthami Arepally, MD

Blood (2017) 130 (Supplement 1): 3617.

https://doi.org/10.1182/blood.V130.Suppl_1.3617.3617

Published: 2017

Journal Articles

Platelet Factor 4 Binds to Released Von Willebrand Factor Strands from Injured Endothelium and Forms a Prothrombotic HIT Antigenic Complex

Ian Johnston, BS, Jose A. Lopez, MD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 2310.

https://doi.org/10.1182/blood.V130.Suppl_1.2310.2310

Published: 2017

Journal Articles

Platelet Release from Infused CD34 + -Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor

Ian Johnston, BS, Vincent M Hayes, BS, Jing Dai, MD PhD, Danuta Jadwiga Jarocha, PhD, Paul Kubes, PhD, Mortimer Poncz, MD, Lubica Rauova, MD PhD

Blood (2016) 128 (22): 1375.

https://doi.org/10.1182/blood.V128.22.1375.1375

Published: 2016

Journal Articles

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Ian Johnston, BS, Lubica Rauova, MD PhD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 1023.

https://doi.org/10.1182/blood.V128.22.1023.1023

Published: 2016

Journal Articles

Apoptosis Might Contribute to the Thrombocytopenia in Heparin-Induced Thrombocytopenia

Tatiana A. Nevzorova, PhD, Elmira R. Mordakhanova, Anastasia A. Ponomareva, PhD, Izabella A. Andrianova, Rustem I. Litvinov, PhD, John W. Weisel, PhD, Lubica Rauova, MD PhD

Blood (2016) 128 (22): 2545.

https://doi.org/10.1182/blood.V128.22.2545.2545

Published: 2016

Journal Articles

Characterization of Human and Murine Anti-Protamine/Heparin Antibodies

Grace M. Lee, MD, Manali Joglekar, MS, Sanjay Khandelwal, Rui Qi, BS, Lubica Rauova, MD PhD, Gowthami M Arepally, MD

Blood (2015) 126 (23): 3461.

https://doi.org/10.1182/blood.V126.23.3461.3461

Published: 2015

Journal Articles

The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis

Junsong Zhou, BS, Yi Wu, Lu Wang, BS, Lubica Rauova, MD PhD, Vincent M Hayes, BS, Mortimer Poncz, MD, David W Essex, MD

Blood (2015) 126 (23): 1032.

https://doi.org/10.1182/blood.V126.23.1032.1032

Published: 2015

Journal Articles

Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia

Izabella Andrianova, Vincent M Hayes, BS, Daria Madeeva, MD, Rustem I. Litvinov, PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, John W. Weisel, PhD, Lubica Rauova, MD PhD

Blood (2015) 126 (23): 2244.

https://doi.org/10.1182/blood.V126.23.2244.2244

Published: 2015

Journal Articles

Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT)

Zheng Cai, PhD, Serge V. Yarovoi, PhD, Zhiquiang Zhu, PhD, Lubica Rauova, MD,PhD, Tatiana Lebedeva, PhD, Mortimer Poncz, MD, Gowthami M Arepally, MD, Douglas B. Cines, MD, Mark I. Greene, MD

Blood (2014) 124 (21): 465.

https://doi.org/10.1182/blood.V124.21.465.465

Published: 2014

Journal Articles

Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells

Manali V. Joglekar, Sanjay Khandelwal, Mortimer Poncz, MD, Lubica Rauova, MD PhD, Gowthami M Arepally, MD

Blood (2014) 124 (21): 4197.

https://doi.org/10.1182/blood.V124.21.4197.4197

Published: 2014

Journal Articles

Anti-Apoptotic Effects of Platelet Factor 4 on Human T-Lymphocytes

Yulia V. Skibo, PhD, Alia R. Fathullina, Elvira V. Romanova, Lubica Rauova, MD PhD, Rustem I. Litvinov, PhD

Blood (2014) 124 (21): 1418.

https://doi.org/10.1182/blood.V124.21.1418.1418

Published: 2014

Journal Articles

New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation

Vincent Hayes, Ian Johnston, BS, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 574.

https://doi.org/10.1182/blood.V124.21.574.574

Published: 2014

Journal Articles

FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT

Daria Madeeva, MD, Valerie Tutwiler, Douglas B. Cines, MD, Mortimer Poncz, MD, Lubica Rauova, MD PhD

Blood (2014) 124 (21): 575.

https://doi.org/10.1182/blood.V124.21.575.575

Published: 2014

Journal Articles

Imaging Morphologic Changes On Platelet and Monocyte Surfaces In Heparin-Induced Thrombocytopenia (HIT)

Lubica Rauova, MD, PhD, Yanjun Zhang, PhD, Vincent M. Hayes, Chandrasekaran Nagaswami, Douglas B. Cines, MD, Jing-fei Dong, MD, PhD, Mortimer Poncz, MD, John W. Weisel, PhD.

Blood (2013) 122 (21): 3533.

https://doi.org/10.1182/blood.V122.21.3533.3533

Published: 2013

Journal Articles

Polyhedrocytes: Compressed Polyhedral Erythrocytes In Contracted Blood Clots and Thrombi

John W. Weisel, PhD, Tatiana Lebedeva, M.D. Ph.D., Chandrasekaran Nagaswami, Vincent M. Hayes, Walter Massefski, Ph.D., Rustem I. Litvinov, Ph.D., Lubica Rauova, MD, PhD, Thomas J. Lowery, Ph.D., Douglas B. Cines, MD

Blood (2013) 122 (21): 452.

https://doi.org/10.1182/blood.V122.21.452.452

Published: 2013

Journal Articles

Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT)

Lubica Rauova, MD, PhD, Daria Madeeva, MD, Valerie Tutwiler, Shahara Bailey, Vincent M. Hayes, Douglas B. Cines, MD, Mortimer Poncz, MD

Blood (2013) 122 (21): 570.

https://doi.org/10.1182/blood.V122.21.570.570

Published: 2013

NARROW

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Inhibition of Neutrophil Extracellular Trap Release through the Disruption of PAD4 Leads to Decreased Neutrophil and Platelet Accumulation at Sites of Venular Vascular Injury in a Murine Model of Heparin-Induced Thrombocytopenia

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Platelet Factor 4 Binds to Released Von Willebrand Factor Strands from Injured Endothelium and Forms a Prothrombotic HIT Antigenic Complex

Platelet Release from Infused CD34 + -Derived Human Megakaryocytes: Lessons from a Natural-Occurring Platelet Bioreactor

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Apoptosis Might Contribute to the Thrombocytopenia in Heparin-Induced Thrombocytopenia

Characterization of Human and Murine Anti-Protamine/Heparin Antibodies

The Second CGHC Motif of Protein Disulfide Isomerase Mediates Thrombosis

Membrane Remodeling By Pathogenic Antibodies Underlies Monocyte Activation in Heparin-Induced Thrombocytopenia

Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT)

Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells

Anti-Apoptotic Effects of Platelet Factor 4 on Human T-Lymphocytes

New Insights into the Prothrombotic State of Heparin-Induced Thrombocytopenia (HIT) Using a Novel Microfluidic System: The Endothelial Lining and “Rolling Barrage” of Activation

FcγRIIA Mediates the Prothrombotic Role of Monocytes in HIT

Imaging Morphologic Changes On Platelet and Monocyte Surfaces In Heparin-Induced Thrombocytopenia (HIT)

Polyhedrocytes: Compressed Polyhedral Erythrocytes In Contracted Blood Clots and Thrombi

Role Of Monocyte Fcγ Receptors In The Prothrombotic State Of Heparin Induced Thrombocytopenia (HIT)

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American Society of Hematology

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American Society of Hematology

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