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M. Graca Almeida-Porada
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Journal Articles

Novel Sheep Model of Sickle Cell Disease Reproduces Human Clinical and Laboratory Parameters

Caroline E. Kuczynski, Iuri V. Perisse, Misha Regouski, Elmira Alipour, Cecily LaPradd, Ying Liu, Michael W. Beaty, Daniel B. Kim-Shapiro, Anthony Atala, Irina Polejaeva, Christopher D. Porada, M. Graca Almeida-Porada
Journal: Blood
Blood (2022) 140 (Supplement 1): 8220.
https://doi.org/10.1182/blood-2022-168050
Published: 2022
Journal Articles

In Utero Transplantation of FVIII-Expressing Human Placental Cells Upregulates Gene Pathways Associated with Immune Tolerance, Altering the Response to Postnatal FVIII Infusion

Martin Rodriguez, Brady Trevisan, Sunil George, Jordan E Shields, Jorge Figueroa, Diane Meares, John Owen, Anthony Atala, Christopher B Doering, H. Trent Spencer, Christopher D Porada, M. Graca Almeida-Porada
Journal: Blood
Blood (2021) 138 (Supplement 1): 1863.
https://doi.org/10.1182/blood-2021-153417
Published: 2021
Journal Articles

Administration of FVIII-Expressing Human Placental Cells to Juvenile Sheep Yields Multi-Organ Engraftment, Therapeutic Plasma FVIII Levels and Alter Immune Signaling Pathways to Evade FVIII Inhibitor Induction

Brady Trevisan, Martin Rodriguez, Jacqueline Dizon, Sunil George, Jordan E Shields, Shannon Lankford, Rebecca Combs, John Owen, Anthony Atala, Christopher B Doering, H. Trent Spencer, Christopher D Porada, M. Graca Almeida-Porada
Journal: Blood
Blood (2021) 138 (Supplement 1): 3966.
https://doi.org/10.1182/blood-2021-151207
Published: 2021
Journal Articles

Using a Human Liver Tissue Equivalent (hLTE) Platform to Define the Functional Impact of Liver-Directed AAV Gene Therapy

Ritu M Ramamurthy, Wen Ting Zheng, Sunil George, Meimei Wan, Yu Zhou, Baisong Lu, Colin E Bishop, Anthony Atala, Christopher D Porada, M. Graca Almeida-Porada
Journal: Blood
Blood (2021) 138 (Supplement 1): 2938.
https://doi.org/10.1182/blood-2021-147917
Published: 2021
Journal Articles

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Brady Trevisan, Martin Rodriguez, BSc, Sunil George, PhD, Shannon Lankford, Jordan E Shields, MS, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-140745
Published: 2020
Journal Articles

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Quan DM Pham, Martin Rodriguez, BSc, Ritu M Ramamurthy, Sunil George, PhD, Jorge Figueroa, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-140883
Published: 2020
Journal Articles

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Martin Rodriguez, BSc, Brady Trevisan, Sunil George, PhD, Ritu M Ramamurthy, Andrew Rabah, Jordan E Shields, MS, Denise Schwahn, DVM, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Michael Gautreaux, PhD, D.ABHI, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-140845
Published: 2020
Journal Articles

Recreating the Hematopoietic Microenvironment in Vitro Using Microfluidic “on-a-Chip” Technology Enables the Study of Interactions of Normal and Malignant HSPC with Specific Bone Marrow Niches

Sunil George, PhD, Julio Aleman, MS, M. Graca Almeida-Porada, MD PhD, Aleksander Skardal, PhD, Christopher D Porada, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3779.
https://doi.org/10.1182/blood.V130.Suppl_1.3779.3779
Published: 2017
Journal Articles

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

M. Graca Almeida-Porada, MD PhD, Sunil George, PhD, Alshaima Morsi, MD, Nadia El-Akabawy, MD, Jorge Figueroa, Jordan E Shields, MS, Diane Meares, Andrew M. Farland, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 361.
https://doi.org/10.1182/blood.V130.Suppl_1.361.361
Published: 2017