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Journal Articles

Outcomes, Causes of Discontinuation and Mutation Profile of Patients with Mantle Cell Lymphoma Who Progressed on Acalabrutinib

Free
Preetesh Jain, MBBS, MDDM, PhD, Rashmi Kanagal-Shamanna, MD, Shaojun Zhang, PhD, Chi Young Ok, MD, Makhdum Ahmed, MD PhD MPH, Diana Nava, Maria Badillo, Krystle Nomie, PhD, Keyur Patel, MD PhD, Hun Ju Lee, MD, F. B. Hagemeister, MD, Luis Fayad, MD, Loretta J. Nastoupil, MD, L. Jeffrey Medeiros, MD, Sattva S. Neelapu, MD, Jorge Enrique Romaguera, Nathan H. Fowler, MD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4151.
https://doi.org/10.1182/blood-2018-99-115179
Published: 2018
Journal Articles

FoxM1-Mediated Signaling Promotes the Progression of Mantle Cell Lymphoma

Free
Hui Guo, PhD, Yixin Yao, PhD, Hui Zhang, Elizabeth Lorence, Makhdum Ahmed, MD PhD MPH, Lingyan Ping, MD PhD, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4176.
https://doi.org/10.1182/blood-2018-99-119349
Published: 2018
Journal Articles

Ibrutinib-Resistant Mantle Cell Lymphoma Undergoes Metabolic Reprogramming Towards Oxphos

Free
Krystle Nomie, PhD, Liang Zhang, MD PhD, Yixin Yao, PhD, Yang Liu, PhD, Shaojun Zhang, PhD, Hui Zhang, Hui Guo, PhD, Makhdum Ahmed, MDPhDMPH, Maria Badillo, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 41.
https://doi.org/10.1182/blood-2018-99-117279
Published: 2018
Journal Articles

Unravelling the Heterogeneity of Mantle Cell Lymphoma Ecosystem By Single Cell RNA Sequencing

Free
Makhdum Ahmed, MD PhD MPH, Hui Guo, PhD, Shaojun Zhang, PhD, Lalit Sehgal, PhD MPhil, Preetesh Jain, MBBS, MDDM, PhD, Rashmi Kanagal-Shamanna, MD, Chi Young Ok, MD, Angela Leeming, Yixin Yao, PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4118.
https://doi.org/10.1182/blood-2018-99-110540
Published: 2018
Journal Articles

Metabolic Profiling Identifies De Novo Nucleotide Synthesis As a Potential Metabolic Vulnerability for Targeted Therapy Against Mantle Cell Lymphoma

Free
Yixin Yao, PhD, Yang Liu, PhD, Hui Guo, PhD, Makhdum Ahmed, MD PhD MPH, Shabnam Bhuiyan, MSc, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2945.
https://doi.org/10.1182/blood-2018-99-112192
Published: 2018
Journal Articles

A Novel Patient-Derived Xenograft Model of Secondary CD20 - CNS Lymphoma for Mechanistic and Therapeutic Exploration

Free
Liang Zhang, MD PhD, Hui Zhang, Hui Guo, PhD, Yuting Sun, PhD, Ningping Feng, PhD, Joseph R Marszalek, PhD, Makhdum Ahmed, MDPhDMPH, Krystle Nomie, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2018-99-112205
Published: 2018
Journal Articles

Clinical and Genomic Characteristics in De Novo Blastoid/Pleomorphic ( dn MCL) and Transformed Blastoid/Pleomorphic (t-MCL) Mantle Cell Lymphoma (MCL) in the Ibrutinib Era: Comprehensive Analysis of 168 Patients

Free
Preetesh Jain, MBBS,MDDM,PhD, Rashmi Kanagal-Shamanna, MD, Shaojun Zhang, PhD, Chi Young Ok, MD, Graciela M. Nogueras González, MPH, Makhdum Ahmed, MDPhDMPH, Gonzalez-Pagan Omarya, Ahmad Ghorab, MDMSc, Prajwal C Boddu, MD, Wendy Chen, Hun Ju Lee, MD, Maria Badillo, Krystle Nomie, PhD, Luis Fayad, MD, Loretta J. Nastoupil, MD, Richard E Champlin, MD, Sattva S. Neelapu, MD, Keyur Patel, MD PhD, L. Jeffrey Medeiros, MD, Jorge Enrique Romaguera, Nathan H. Fowler, MD, Linghua Wang, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1599.
https://doi.org/10.1182/blood-2018-99-115360
Published: 2018
Journal Articles

Targeting the Paracaspase MALT1: A Potential Therapy to Overcome Ibrutinib Resistance in Relapsed/Refractory Mantle Cell Lymphoma Patients

Free
Changying Jiang, PhD, Shengjian Huang, PhD, Yang Liu, MD, Carrie Li, Hui Guo, MD PhD, Jeffrey Wang, Elyse Lopez, Hui Zhang, Elizabeth A Lorence, MPH, Maria Merolle, Swathi Balaji, Makhdum Ahmed, MD MPH, PhD, Krystle Nomie, PhD, Xin Lin, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 574.
https://doi.org/10.1182/blood.V130.Suppl_1.574.574
Published: 2017
Journal Articles

FoxM1: A New Therapeutic Target for Mantle Cell Lymphoma

Free
Hui Guo, MD PhD, Hui Zhang, Makhdum Ahmed, MD MPH, PhD, Yang Liu, MD, Shengjian Huang, PhD, Victoria Zhang, Jeffrey Wang, Elyse Lopez, Elizabeth A Lorence, MPH, Jacqueline Wang, Swathi Balaji, Merolle Maria, Changying Jiang, PhD, Krystle Nomie, PhD, Michael Wang, BS, Liang Zhang, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1469.
https://doi.org/10.1182/blood.V130.Suppl_1.1469.1469
Published: 2017
Journal Articles

Molecular Pathways Associated with Ibrutinib Resistance in Mantle Cell Lymphoma

Free
Liang Zhang, MD PhD, Krystle Nomie, PhD, Shaojun Zhang, PhD, Yang Liu, MD, Hui Guo, MD PhD, Shengjian Huang, PhD, Jeffrey Wang, Elyse Lopez, Hui Zhang, Elizabeth A Lorence, MPH, Maria Merolle, Swathi Balaji, Makhdum Ahmed, MD MPH, PhD, Changying Jiang, PhD, Linghua Wang, Michael Wang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2738.
https://doi.org/10.1182/blood.V130.Suppl_1.2738.2738
Published: 2017
Journal Articles

Resistance Mechanisms Underlying Venetoclax Resistance in Mantle Cell Lymphoma

Free
Shengjian Huang, PhD, Changying Jiang, PhD, Hui Guo, MD PhD, Jeffrey Wang, Yang Liu, MD, Carrie Li, Elyse Lopez, Hui Zhang, Elizabeth A Lorence, MPH, Maria Merolle, Swathi Balaji, Makhdum Ahmed, MD MPH, PhD, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2749.
https://doi.org/10.1182/blood.V130.Suppl_1.2749.2749
Published: 2017
Journal Articles

Targeting Oxphos Pathway Against Ibrutinib Resistance to Mantle Cell Lymphoma

Free
Yang Liu, PhD, Taylor Bell, Hui Zhang, Yuting Sun, Carrie J Li, Ningping Feng, PhD, Shengjian Huang, Hui Guo, MD PhD, Jack Wang, Makhdum Ahmed, MD MPH, Victoria Zhang, Laura T Lam, PhD, Krystle Nomie, PhD, Liang Zhang, MD PhD, Maria E Di Francesco, Joe Marszalek, Michael Wang, MD
Journal: Blood
Blood (2016) 128 (22): 290.
https://doi.org/10.1182/blood.V128.22.290.290
Published: 2016
Journal Articles

CUDC-907: An Oral HDAC/PI3K Dual Inhibitor with Strong Preclinical Efficacy in MCL Model

Free
Jordan N Boyle, Caroline R Kim, Hui Guo, MD PhD, Taylor Bell, Shengjian Huang, Carrie J Li, Yang Liu, PhD, Hui Zhang, Jack Wang, Victoria Zhang, Makhdum Ahmed, MD MPH, Laura T Lam, PhD, Krystle Nomie, PhD, Liang Zhang, MD PhD, Dongfeng Zeng, Michael Wang, MD
Journal: Blood
Blood (2016) 128 (22): 4183.
https://doi.org/10.1182/blood.V128.22.4183.4183
Published: 2016
Journal Articles

Novel Bruton's Tyrosine Kinase Inhibitor Bgb-3111 Demonstrates Potent Activity in Mantle Cell Lymphoma

Free
Carrie J Li, Yang Liu, PhD, Taylor Bell, Jack Wang, Hui Guo, MD PhD, Makhdum Ahmed, MD MPH, Hui Zhang, Laura T Lam, PhD, Krystle Nomie, PhD, Lai Wang, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2016) 128 (22): 5374.
https://doi.org/10.1182/blood.V128.22.5374.5374
Published: 2016
Journal Articles

Genetic and Molecular Characterization of Ibrutinib-Resistant Mantle Cell Lymphoma: Designing Innovative Therapeutic Strategies

Free
Hui Guo, MD PhD, Shengjian Huang, Yang Liu, PhD, Carrie J Li, Jack Wang, Victoria Zhang, Makhdum Ahmed, MD MPH, Laura T Lam, PhD, Hui Zhang, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2016) 128 (22): 1838.
https://doi.org/10.1182/blood.V128.22.1838.1838
Published: 2016
Journal Articles

Patient-Derived Xenograft Model in B-Cell Lymphoma: A Platform for a Personalized Clinical Trial

Free
Taylor Bell, Hui Zhang, Makhdum Ahmed, MD MPH, Hui Guo, MD PhD, Carrie J Li, Yang Liu, PhD, Laura T Lam, PhD, Zhihong Chen, Jack Wang, Victoria Zhang, Krystle Nomie, PhD, Liang Zhang, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2016) 128 (22): 1839.
https://doi.org/10.1182/blood.V128.22.1839.1839
Published: 2016
Journal Articles

Chemotherapy-Free Induction with Ibrutinib-Rituximab Followed By Shortened Cycles of Chemo-Immunotherapy Consolidation in Young, Newly Diagnosed Mantle Cell Lymphoma Patients: A Phase II Clinical Trial

Free
Michael Wang, MD, Hun Ju Lee, MD, Selvi Thirumurthi, MD, Hubert H Chuang, MD PhD, Fredrick B. Hagemeister, MD, Jason R. Westin, MD, Luis E. Fayad, MD, Felipe Samaniego, MD, Francesco Turturro, MD, Wendy Chen, Onyeka Oriabure, Steven Y Huang, MD, Shaoying Li, MD, Liang Zhang, MD PhD, Maria Badillo, MS, Kimberly H Hartig, Makhdum Ahmed, MD MPH, Krystle Nomie, PhD, Laura T Lam, PhD, Alicia A Addison, Jorge E. Romaguera, MD
Journal: Blood
Blood (2016) 128 (22): 147.
https://doi.org/10.1182/blood.V128.22.147.147
Published: 2016
Journal Articles

Pre-Clinical Evaluation of the PI3K-p110β/δ Inhibitor KA2237 in Mantle Cell Lymphoma

Free
Shengjian Huang, Loretta J. Nastoupil, MD, Hui Guo, MD PhD, Taylor Bell, Makhdum Ahmed, MD MPH, Carrie J Li, Jack Wang, Yang Liu, PhD, Victoria Zhang, Caroline R Kim, Jordan N Boyle, Elizabeth A Lorence, Laura T Lam, PhD, Zhihong Chen, Hui Zhang, Stephen Joseph Shuttleworth, PhD, Krystle Nomie, PhD, Michael Wang, MD, Liang Zhang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1837.
https://doi.org/10.1182/blood.V128.22.1837.1837
Published: 2016