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Journal Articles

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Kathryn G. Roberts, PhD, Samuel W. Brady, PhD, Zhaohui Gu, PhD, Lei Shi, PhD, Stanley Pounds, PhD, Deqing Pei, MS, Cheng Cheng, PhD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Chunxu Qu, PhD, Ashley Hill, BS, Xiaotu Ma, Lei Wei, PhD, Sasi Arunachalam, PhD, Kohei Hagiwara, MD, Yangling Liu, Diane Flasch, Yu Liu, PhD, Matthew Parker, PhD, Xiaolong Chen, PhD, Yongjin Li, PhD, Yiping Fan, PhD, Robert Michael, PhD, Michael Rusch, BS, Mark Wilkinson, Scott Foy, PhD, Dale Hedges, PhD, Scott Newman, PhD, Xin Zhou, PhD, Jian Wang, Shalini C. Reshmi, PhD, Julie M. Gastier-Foster, PhD, Patee Gesuwan, Malcolm A Smith, MD PhD, Daniela S. Gerhard, PhD, Naomi Winick, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Eric Larsen, MD, Elizabeth A. Raetz, MD, Michael J. Borowitz, MD PhD, Brent L Wood, MD PhD, William L. Carroll, MD, Patrick A. Zweidler-McKay, MD PhD, Karen R. Rabin, MD PhD, Leonard A. Mattano, MD, Kelly Maloney, MD, Stuart S. Winter, MD, Michael J. Burke, MD, Wanda L. Salzer, MD, Kimberly P. Dunsmore, Anne Angiolillo, MD, Kristine R Crews, PharmD, James R. Downing, MD, Sima Jeha, MD, William E. Evans, PharmD, Ching-Hon Pui, MD, Jun J. Yang, PhD, Mary V. Relling, PharmD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MD

Blood (2019) 134 (Supplement_1): 649.

https://doi.org/10.1182/blood-2019-124881

Published: 2019

Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Richard B. Lock, PhD, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Katerina Bendak, PhD, Cara E Toscan, PhD, Chelsea Mayoh, Stephen W Erickson, PhD, Beverly A Teicher, PhD, Malcolm A Smith, MD PhD

Blood (2019) 134 (Supplement_1): 3875.

https://doi.org/10.1182/blood-2019-123867

Published: 2019

Journal Articles

Discovery and Validation of Cell-Surface Protein Mesothelin (MSLN) As a Novel Therapeutic Target in AML: Results from the COG/NCI Target AML Initiative

Blood (2016) 128 (22): 2873.

https://doi.org/10.1182/blood.V128.22.2873.2873

Published: 2016

Journal Articles

Marked Differences in the Genomic Landscape of Pediatric Compared to Adult Acute Myeloid Leukemia: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative

Jason E Farrar, MD, Hamid Bolouri, PhD, Rhonda E. Ries, MA, Timothy Junius Triche, Jr., PhD, Emilia L. Lim, PhD, Todd A. Alonzo, PhD, Yussanne Ma, PhD, Richard Moore, PhD, Andrew J. Mungall, Marco A. Marra, PhD, Jaime Guidry Auvil, PhD, Tanja M. Davidsen, PhD, Patee Gesuwan, Leandro C. Hermida, E. Anders Kolb, MD, Alan S. Gamis, MD MPH, Malcolm A. Smith, MD PhD, Daniela S. Gerhard, PhD, Soheil Meshinchi

Blood (2016) 128 (22): 595.

https://doi.org/10.1182/blood.V128.22.595.595

Published: 2016

Journal Articles

Divergent Epigenomes in Pediatric and Adult Acute Myeloid Leukemia Implicate Cell of Origin and Transcriptional Silencing of Immune Responses As Sources of Clinically Relevant Heterogeneity: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative

Blood (2016) 128 (22): 1046.

https://doi.org/10.1182/blood.V128.22.1046.1046

Published: 2016

Journal Articles

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Thomas B. Alexander, MD MPH, Zhaohui Gu, PhD, John K Choi, MD, Mignon L. Loh, MD, John Horan, MD MPH, Barbara Buldini, MD, Giuseppe Basso, Sarah Elitzur, MD, C. Michel Zwaan, MD PhD, Valerie de Haas, MD PhD, Allen Eng Juh Yeoh, MD, Dirk Reinhardt, MD PhD, Daisuke Tomizawa, MD, PhD, Tim Lammens, Barbara De Moerloose, MD, Li Zhou, PhD, Hiroki Hori, MD PhD, Anthony V. Moorman, PhD, Andrew S. Moore, MBBS FRACP PhD, Ondrej Hrusak, MD PhD, Soheil Meshinchi, MD PhD, Etan Orgel, MD MS, Meenakshi Devidas, PhD, Stephen P. Hunger, MD, Jamie M Guidry Auvil, Malcolm A. Smith, MD PhD, Tanja M. Davidsen, PhD, Leandro C. Hermida, Patee Gesuwan, Marco A. Marra, PhD, Yussanne Ma, PhD, Andrew J. Mungall, Richard Moore, PhD, Daniela S. Gerhard, PhD, Xueyuan Cao, Lei Shi, PhD, Stanley Pounds, PhD, Hiroto Inaba, MD PhD, Charles Mullighan, MBBS, MSc, MD

Blood (2016) 128 (22): 454.

https://doi.org/10.1182/blood.V128.22.454.454

Published: 2016

Journal Articles

Alteration of Chromatin Modifiers and Misregulation of Transcription Factors Define the Genomic Profile of Infant AML

Rhonda E. Ries, MA, Hamid Bolouri, PhD, Jason E Farrar, MD, Emilia L. Lim, PhD, Timothy Junius Triche, Jr., PhD, Katherine Tarlock, MD, Jaime Guidry Auvil, PhD, Betsy A. Hirsch, PhD, Susana C. Raimondi, PhD, Yussanne Ma, PhD, Marco A. Marra, PhD, Richard Aplenc, MD PhD, Erin M. Guest, MD, E. Anders Kolb, MD, Alan S. Gamis, MD MPH, Malcolm A. Smith, MD PhD, Daniela S. Gerhard, PhD, Soheil Meshinchi, MD PhD

Blood (2016) 128 (22): 774.

https://doi.org/10.1182/blood.V128.22.774.774

Published: 2016

Journal Articles

TET2 Mutations Are Highly Associated with RUNX1-RUNX1T1 Translocations and NPMc+ in Childhood AML: a Report from Children's Oncology Group AAML03P1, AAML0531 and NCI/COG Target AML Initiative

Blood (2015) 126 (23): 1368.

https://doi.org/10.1182/blood.V126.23.1368.1368

Published: 2015

Journal Articles

ASXL1 and ASXL2 Mutations in Childhood AML Are Strongly Associated with t(8;21) but Do Not Independently Impact on Prognosis: A Report from the Children's Oncology Group and NCI/COG Target Initiative

Jason E. Farrar, MD, Todd A. Alonzo, PhD, Rhonda E. Ries, MA, Robert B. Gerbing, MA, Jaime M. Guidry Auvil, PhD, Tanja M. Davidsen, PhD, Patee Gesuwan, Leandro C. Hermida, Marco A Marra, PhD, Andrew J. Mungall, PhD, Karen Mungall, PhD, Yussanne Ma, PhD, William Long, PhD, Stuart Zong, E. Anders Kolb, MD, Malcolm A. Smith, MD PhD, Daniela S. Gerhard, PhD, Alan S. Gamis, MD MPH, Soheil Meshinchi, MD PhD

Blood (2015) 126 (23): 2587.

https://doi.org/10.1182/blood.V126.23.2587.2587

Published: 2015

Journal Articles

Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia

Michelle L. Churchman, PhD, Luke Jones, BSc(Hons), Kathryn Evans, BSc(Hons), Jennifer Richmond, BSc(Hons), Irina M Shapiro, PhD, Jonathan A. Pachter, PhD, David T. Weaver, PhD, Peter J Houghton, PhD, Malcolm A. Smith, MD PhD, Richard B Lock, PhD, Charles G. Mullighan, MBBS, MSc, MD

Blood (2015) 126 (23): 3766.

https://doi.org/10.1182/blood.V126.23.3766.3766

Published: 2015

Journal Articles

Comprehensive Sequence Analysis of Relapse and Refractory Pediatric Acute Myeloid Leukemia Identifies miRNA and mRNA Transcripts Associated with Treatment Resistance - a Report from the COG/NCI-Target AML Initiative

Emilia L. Lim, Diane L. Trinh, MSc, Rhonda E. Ries, MA, Yussanne Ma, PhD, James Topham, Maya D. Hughes, MD, Erin Pleasance, PhD, Andrew J. Mungall, PhD, Richard Moore, PhD, Yongjun Zhao, PhD, Daniela S. Gerhard, PhD, Vivian Oehler, MD, E. Anders Kolb, MD, Alan S. Gamis, MD MPH, Malcolm A. Smith, MD PhD, Todd A. Alonzo, PhD, Robert J. Arceci, MD PhD, Soheil Meshinchi, MD PhD, Marco A. Marra, PhD

Blood (2015) 126 (23): 687.

https://doi.org/10.1182/blood.V126.23.687.687

Published: 2015

Journal Articles

The Genomic Landscape of Childhood T-Lineage Acute Lymphoblastic Leukemia

Blood (2015) 126 (23): 691.

https://doi.org/10.1182/blood.V126.23.691.691

Published: 2015

Journal Articles

Comprehensive Genomic and Transcript Profiling of CBL Gene in Childhood AML: A Report from Children's Oncology Group Studies AAML03P1, AAML0531 and COG/NCI Target AML Initiative

Blood (2015) 126 (23): 170.

https://doi.org/10.1182/blood.V126.23.170.170

Published: 2015

Journal Articles

Rearrangements in Nucleoporin Family of Genes in Childhood Acute Myeloid Leukemia: A Report from Children Oncology Group and NCI/COG Target AML Initiative

Blood (2015) 126 (23): 169.

https://doi.org/10.1182/blood.V126.23.169.169

Published: 2015

Journal Articles

CSF3R Mutations Represent a Novel Therapeutic Target in Pediatric AML with a High Degree of Overlap with CEBPA Mutations: a Report from COG AAML0531 and COG/NCI Target AML Initiative

Blood (2015) 126 (23): 174.

https://doi.org/10.1182/blood.V126.23.174.174

Published: 2015

Journal Articles

Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative

Blood (2015) 126 (23): 87.

https://doi.org/10.1182/blood.V126.23.87.87

Published: 2015

Journal Articles

Targeted Cancer Therapy in High-Risk Pediatric Leukemia Using Global Phosphotyrosine Profiling

Sibasish Dolai, PhD, Keith CS Sia, BSc(Hons), Alissa K Robbins, BSc(Hons), Ling Zhong, PhD, Sue Heatley, PhD, Tiffaney Vincent, BS, Falko Hochgräfe, PhD, Raushan T. Kurmasheva, PhD, Deborah L White, PhD FFSc (RCPA), Peter J. Houghton, PhD, Malcolm A. Smith, MD PhD, David T. Teachey, MD, Roger J Daly, PhD, Mark J Raftery, PhD, Richard B. Lock, PhD

Blood (2014) 124 (21): 969.

https://doi.org/10.1182/blood.V124.21.969.969

Published: 2014

Journal Articles

PIM3-SCO2 Fusion Is a Novel Transcription-Induced Chimera That Is Highly Prevalent In Childhood AML

Julia Kuhn, BA, Daoud Meerzaman, MD, Rhonda E. Ries, MA, Filippo Milano, MD, PhD, Alan S. Gamis, MD, MPH, Todd A. Alonzo, PhD, Jaime Guidry-Auvil, Ph.D., Tanja M. Davidsen, PhD, Malcolm A. Smith, MD, PhD, Yan Chunhua, Chih Hao Hsu, Cu Nguyen, Daniela S. Gerhard, Ph.D., Daniel Wai, Robert J. Arceci, MD, PhD, Soheil Meshinchi, MD, PhD

Blood (2013) 122 (21): 2549.

https://doi.org/10.1182/blood.V122.21.2549.2549

Published: 2013

Journal Articles

Genome-Wide DNA Methylation Analysis Reveals Biological and Clinical Insights In Relapsed Childhood Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

Huimin Geng, PhD, Mignon L. Loh, MD, Richard C. Harvey, PhD, I-Ming Chen, DVM, Meenakshi Devidas, PhD, Tanja M. Davidsen, PhD, Jaime M. Guidry Auvil, PhD, Daniela S. Gerhard, Ph.D., Malcolm A. Smith, MD PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Julie M. Gastier-Foster, PhD, Cheryl L. Willman, MD, Charles G. Mullighan, MBBS MSc MD, Stephen P. Hunger, MD, Ari Melnick, MD

Blood (2013) 122 (21): 3736.

https://doi.org/10.1182/blood.V122.21.3736.3736

Published: 2013

Journal Articles

Comparison Of Mutational Profiles Of Diagnosis and Relapsed Pediatric B-Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

Blood (2013) 122 (21): 824.

https://doi.org/10.1182/blood.V122.21.824.824

Published: 2013

NARROW

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Discovery and Validation of Cell-Surface Protein Mesothelin (MSLN) As a Novel Therapeutic Target in AML: Results from the COG/NCI Target AML Initiative

Marked Differences in the Genomic Landscape of Pediatric Compared to Adult Acute Myeloid Leukemia: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Alteration of Chromatin Modifiers and Misregulation of Transcription Factors Define the Genomic Profile of Infant AML

TET2 Mutations Are Highly Associated with RUNX1-RUNX1T1 Translocations and NPMc+ in Childhood AML: a Report from Children's Oncology Group AAML03P1, AAML0531 and NCI/COG Target AML Initiative

ASXL1 and ASXL2 Mutations in Childhood AML Are Strongly Associated with t(8;21) but Do Not Independently Impact on Prognosis: A Report from the Children's Oncology Group and NCI/COG Target Initiative

Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia

Comprehensive Sequence Analysis of Relapse and Refractory Pediatric Acute Myeloid Leukemia Identifies miRNA and mRNA Transcripts Associated with Treatment Resistance - a Report from the COG/NCI-Target AML Initiative

The Genomic Landscape of Childhood T-Lineage Acute Lymphoblastic Leukemia

Comprehensive Genomic and Transcript Profiling of CBL Gene in Childhood AML: A Report from Children's Oncology Group Studies AAML03P1, AAML0531 and COG/NCI Target AML Initiative

Rearrangements in Nucleoporin Family of Genes in Childhood Acute Myeloid Leukemia: A Report from Children Oncology Group and NCI/COG Target AML Initiative

CSF3R Mutations Represent a Novel Therapeutic Target in Pediatric AML with a High Degree of Overlap with CEBPA Mutations: a Report from COG AAML0531 and COG/NCI Target AML Initiative

Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative

Targeted Cancer Therapy in High-Risk Pediatric Leukemia Using Global Phosphotyrosine Profiling

PIM3-SCO2 Fusion Is a Novel Transcription-Induced Chimera That Is Highly Prevalent In Childhood AML

Genome-Wide DNA Methylation Analysis Reveals Biological and Clinical Insights In Relapsed Childhood Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

Comparison Of Mutational Profiles Of Diagnosis and Relapsed Pediatric B-Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

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American Society of Hematology

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American Society of Hematology

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