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Margaret S Lee, PhD
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Journal Articles

Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma

Melissa A. Fischer, PhD, Sharon Friedlander, PhD, Leah Hogdal, PhD, Pia Arrate, Hua Chang, PhD, Trinayan Kashyap, MS, Christian Argueta, PhD, Boris Klebanov, MA, MS, William Senapedis, PhD, Erkan Baloglu, PhD MBA, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael R. Savona, MD
Journal: Blood
Blood (2016) 128 (22): 3949.
https://doi.org/10.1182/blood.V128.22.3949.3949
Published: 2016
Journal Articles

Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Christian Argueta, PhD, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD PhD, Yosef Landesman, PhD, William Senapedis, PhD
Journal: Blood
Blood (2016) 128 (22): 5660.
https://doi.org/10.1182/blood.V128.22.5660.5660
Published: 2016
Journal Articles

Synergistic Anti-Tumor Effect of KPT-8602, a Second Generation Selective Inhibitor of Nuclear Export (SINE) Compound, and Panobinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor in Multiple Myeloma

Christian Argueta, PhD, Hua Chang, PhD, Trinayan Kashyap, MS, Sivan Elloul, PhD, Sharon Friedlander, PhD, Margaret S. Lee, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA, William Senapedis, PhD, Erkan Baloglu, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 3298.
https://doi.org/10.1182/blood.V128.22.3298.3298
Published: 2016
Journal Articles

Development of a Pharmacodynamic Assay for XPO1 Occupancy Using Fluorescence Cross Correlation Spectroscopy (FCCS)

Marsha L. Crochiere, PhD, Stefan Hannus, PhD, Kerrin Hansen, Frank Becker, PhD, Joel Ellis, PhD, Margaret S. Lee, PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2015) 126 (23): 2487.
https://doi.org/10.1182/blood.V126.23.2487.2487
Published: 2015
Journal Articles

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Margaret S. Lee, PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2015) 126 (23): 3683.
https://doi.org/10.1182/blood.V126.23.3683.3683
Published: 2015
Journal Articles

ATL313, A Potent, and Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Richard Rickles, PhD, Mahesh Padval, PhD, Thomas Giordanno, Jayson M Rieger, PhD, MBA, Margaret S Lee, PhD
Journal: Blood
Blood (2010) 116 (21): 2990.
https://doi.org/10.1182/blood.V116.21.2990.2990
Published: 2010
Journal Articles

A2A or Beta-2 Adrenergic Receptor Agonist Synergies Induce Distinct Patterns of Gene Expression Relevant to Multiple Myeloma Cell Survival.

Winnie F. Tam, PhD, Richard J Rickles, PhD, Thomas Giordano, Alexis Borisy, Margaret S. Lee, PhD
Journal: Blood
Blood (2009) 114 (22): 3831.
https://doi.org/10.1182/blood.V114.22.3831.3831
Published: 2009
Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonist Synergy in B-Cell Malignancies: Selectivity, Breadth of Activity and Effects of Chronic Exposure.

Richard J. Rickles, PhD, Winnie F. Tam, PhD, Antoaneta Necheva, MSc, Thomas Giordano, Alexis A. Borisy, Margaret S. Lee, PhD
Journal: Blood
Blood (2009) 114 (22): 3762.
https://doi.org/10.1182/blood.V114.22.3762.3762
Published: 2009
Journal Articles

Synergistic Activity of Adenosine A2A and Beta-2 Adrenergic Receptor Agonists in Myeloma Cells in the Context of Tumor-Stromal Interactions

Douglas W. McMillin, PhD, Richard Rickles, Joseph Negri, Jake Delmore, Melissa G. Ooi, MD, Melissa Farwell, David Crowe, Mei Chen, William Avery, Vikram Kansra, PhD, Kenneth C. Anderson, MD, Margaret S. Lee, PhD, Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2663.
https://doi.org/10.1182/blood.V112.11.2663.2663
Published: 2008
Journal Articles

Adenosine A2A and Beta-2 Adrenergic Receptor Agonism: Novel Selective and Synergistic Multiple Myeloma Targets Discovered through Systematic Combination Screening

Richard J. Rickles, Ph.D., Laura Pierce, Thomas Giordano, Winnie F. Tam, Ph.D., William Avery, Melissa Farwell, David Crowe, Mei Chen, Ph.D., Alexander Brown, Vikram Kansra, PhD, Steffan T. Nawrocki, PhD, Jennifer S Carew, Ph.D., Francis J Giles, MD, Margaret S Lee, PhD
Journal: Blood
Blood (2008) 112 (11): 384.
https://doi.org/10.1182/blood.V112.11.384.384
Published: 2008
Journal Articles

Preclinical Evaluation of CRx-501, a Potent Selective A2A Agonist as a Novel Drug Candidate for the Treatment of Multiple Myeloma

Richard J Rickles, Ph.D., Laura Pierce, Thomas Giordano, William Avery, Melissa Farwell, David Crowe, Winnie F. Tam, Ph.D., Mei Chen, Ph.D., Vikram Kansra, PhD, Douglas W. McMillin, BSc, PhD, Kenneth C Anderson, MD, Constantine Mitsiades, M.D., Ph.D., Margaret S. Lee, PhD
Journal: Blood
Blood (2008) 112 (11): 252.
https://doi.org/10.1182/blood.V112.11.252.252
Published: 2008