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Journal Articles

Reduction of ARHGAP21 Alters Platelet Biogenesis in Vitro and Accelerates Hemostatic Response In Vivo

Mariana Lazarini, PhD, Vanessa Bernusso, MSc, Karla P.V Ferro, PhD, Adriana Silva Santos Duarte, PhD, Cristina Pontes Vicente, PhD, Erich V De Paula, MD PhD, Sara T Olalla Saad, MD PhD

Blood (2020) 136 (Supplement 1): 13.

https://doi.org/10.1182/blood-2020-141109

Published: 2020

Journal Articles

ARHGAP21 Is Upregulated and Triggers the Modulation of Rho Gtpase Signaling Pathways during Megakaryocytic Differentiation

Vanessa Aline Bernusso, Mariana Lazarini, PhD, João Agostinho Machado-Neto, PhD, Karin Spat Albino Barcellos, PhD, Sara Teresinha Olalla Saad, PhD MD

Blood (2015) 126 (23): 4760.

https://doi.org/10.1182/blood.V126.23.4760.4760

Published: 2015

Journal Articles

Stathmin 1 Silencing Amplifies Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

João Agostinho Machado-Neto, MSc, Paula de Melo Campos, MD, Patricia Favaro, PhD, Mariana Lazarini, PhD, Adriana Silva Santos Duarte, PhD, Irene Lorand-Metze, MD PhD, Sara Teresinha Olalla Saad, MD PhD, Fabiola Traina, MD PhD

Blood (2014) 124 (21): 3229.

https://doi.org/10.1182/blood.V124.21.3229.3229

Published: 2014

Journal Articles

BRD4 Short Isoform Is a Myelodysplasia Prognostic Marker Involved in Inappropriate DNA Damage Response

Fernando V Pericole, MD, Fernanda Marconi Roversi, PhD, Adriana Silva Santos Duarte, PhD, Bruna Palodetto, MSc, Flavia Adolfo Corrocher, MSc, Fabiola Traina, MD PhD, Mariana Lazarini, PhD, Sara T Olalla Saad, MD PhD

Blood (2014) 124 (21): 3234.

https://doi.org/10.1182/blood.V124.21.3234.3234

Published: 2014

Journal Articles

Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis

Mariana Lazarini, PhD, João Agostinho Machado-Neto, MSc, Adriana Silva Santos Duarte, PhD, Fernando V Pericole, MD, Karla Priscila Ferro, PhD, Paula de Melo Campos, MD, Fabiola Traina, MD PhD, Sara T.O. Saad, MD, PhD

Blood (2014) 124 (21): 3239.

https://doi.org/10.1182/blood.V124.21.3239.3239

Published: 2014

Journal Articles

Ndfip Is a Novel Autophagy Regulator and It Is Deregulated In Acute Myeloid Leukemia

Fernando V Pericole, MD, Mariana Lazarini, PhD, Karla Priscila Vieira, PhD, Sara Teresinha Olalla Saad, MD, PhD

Blood (2013) 122 (21): 1419.

https://doi.org/10.1182/blood.V122.21.1419.1419

Published: 2013

Journal Articles

Rhodiola Rosea Extract Reduces Autophagy In Acute Myeloid Leukemia Transformed From Myelodysplastic Syndromes Tumor Xenograft Model

Cristiane Okuda Torello, PhD, Joao Machado-Neto, MSc, Karla P. Veira, Victor Maso, Andrana Calgarotto, PhD, Gilberto Carlos Franchi-Junior, BSc, Mariana Lazarini, PhD, Mary L. S. Queiroz, MD, PhD, Sara Teresinha Saad, MD, PhD

Blood (2013) 122 (21): 5219.

https://doi.org/10.1182/blood.V122.21.5219.5219

Published: 2013

Journal Articles

Inflammasome and Autophagy Activation In Symptomatic Multiple Myeloma Could Predict Response To Thalidomide-Based Chemotherapy

Fernando V Pericole, MD, Adriana Silva Santos Duarte, PhD, Mariana Lazarini, PhD, Sara Teresinha Olalla Saad, MD, PhD

Blood (2013) 122 (21): 3131.

https://doi.org/10.1182/blood.V122.21.3131.3131

Published: 2013

Journal Articles

Stathmin 1 Is Involved In The Highly Proliferative Phenotype Of High-Risk Myelodysplastic Syndromes and Acute Leukemia Cells

João Agostinho Machado-Neto, MSc, Paula de Melo Campos, MD, Patricia Favaro, PhD, Mariana Lazarini, PhD, Irene Lorand-Metze, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara Teresinha Olalla Saad, MD, PhD, Fabiola Traina, MD, PhD

Blood (2013) 122 (21): 861.

https://doi.org/10.1182/blood.V122.21.861.861

Published: 2013

Journal Articles

ANKHD1 Interacts with the Proapoptotic Protein SIVA and Plays a Role in the Proliferation and Stathmin Activation of Acute Leukemia Cells.

Joao Machado-Neto, MSc, Mariana Lazarini, PhD, Patricia Favaro, PhD, Paula de Melo Campos, MD, Renata Scopim-Ribeiro, BSc, Gilberto Carlos Franchi-Junior, BSc, Alexandre Eduardo Nowill, MD, Irene Lorand-Metze, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara T. Olalla Saad, MD, PhD, Fabiola Traina, MD, PhD

Blood (2012) 120 (21): 2419.

https://doi.org/10.1182/blood.V120.21.2419.2419

Published: 2012

Journal Articles

Autophagy Regulation and Dysfunction in Bone Marrow Malignancies

Fernando V Pericole, MD, Mariana Lazarini, PhD, Adriana S. S. Duarte, PhD, João Machado-Neto, MSc, Sara T. Olalla Saad, MD, PhD

Blood (2012) 120 (21): 4623.

https://doi.org/10.1182/blood.V120.21.4623.4623

Published: 2012

Journal Articles

BNIP3 Is Downregulated in Myelodysplastic Syndromes and Acute Myeloid Leukemia and Is a Potential Molecular Target for Decitabine

Mariana Lazarini, PhD, Joao Machado-Neto, MSc, Adriana S. S. Duarte, PhD, Fernando V Pericole, MD, Patricia Favaro, PhD, Karin Spat Albino Barcellos, PhD, Fabiola Traina, MD, PhD, Sara T. Olalla Saad, MD, PhD

Blood (2012) 120 (21): 1708.

https://doi.org/10.1182/blood.V120.21.1708.1708

Published: 2012

Journal Articles

Downregulation of IRS2 in Myelodysplastic Syndrome (MDS) May Be Related to Impaired Cell Differentiation,

Joao Machado-Neto, MSc, Patricia Favaro, PhD, Mariana Lazarini, PhD, Adriana S S Duarte, PhD, Leticia Fröhlich Archangelo, PhD, Irene Lorand-Metze, MD, PhD, Fernando Ferreira Costa, MD, PhD, Sara T Olalla Saad, MD, PhD, Fabiola Traina, MD, PhD

Blood (2011) 118 (21): 3814.

https://doi.org/10.1182/blood.V118.21.3814.3814

Published: 2011

Journal Articles

In Vitro and In Vivo downregulation of Leukemogenesis by FMNL1 Inhibition In Namalwa Cell Line

Patricia Favaro, PhD, Fabiola Traina, MD, PhD, Joao Machado-Neto, MSc, Mariana Lazarini, PhD, Matheus Rodrigues Lopes, B.Sc., Fernando Ferreira Costa, MD, PhD, Sara T. Olalla Saad, MD, PhD

Blood (2011) 118 (21): 1485.

https://doi.org/10.1182/blood.V118.21.1485.1485

Published: 2011

Journal Articles

IRS2 Is Dowregulated In Primary MDS Cells and During MDS Erythroid Differentiation

Joao Machado-Neto, BSci, Patricia Favaro, Ph.D., Mariana Lazarini, PhD, Adriana S S Duarte, PhD, Letícia Fröhlich-Archangelo, Fernando Ferreira Costa, Ph.D., M.D., Sara T. Olalla-Saad, M.D., Ph.D., Fabiola Traina, MD, PhD

Blood (2010) 116 (21): 1886.

https://doi.org/10.1182/blood.V116.21.1886.1886

Published: 2010

Journal Articles

Knockdown of Insulin Receptor Substrate 1 (IRS1); a Partner of BCR-ABL, Results In Decrease In Proliferation and Downregulation of AKT/mTOR and MAPK Pathways In K562 Cells

Joao Machado-Neto, BSci, Patricia Favaro, Ph.D., Mariana Lazarini, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T. Olalla-Saad, M.D., Ph.D., Fabiola Traina, MD, PhD

Blood (2010) 116 (21): 4459.

https://doi.org/10.1182/blood.V116.21.4459.4459

Published: 2010

Journal Articles

Alpha-Catenin, ARHGAP21 and β-Catenin Are Abnormally Expressed in Bone Marrow Cells From Patients with Myelodysplatic Syndromes and Are a Possible Target for Decitabine Treatment.

Karin Spat Barcellos, PhD, in, Molecular, Biology, Sheila Maria Winnischofer, PhD, Mariana Lazarini, Master, Degree, Doctorate, Stude, Adriana Silva Santos Duarte, PhD, Carolina Louzao Bigarella, PhD, Fabiola Traina, MD, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T.O Saad, M.D., Ph.D.

Blood (2009) 114 (22): 1778.

https://doi.org/10.1182/blood.V114.22.1778.1778

Published: 2009

Journal Articles

IRS1 and SHP2 Signaling in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Fabiola Traina, MD, PhD, João Agostinho Machado Neto, BSci, Arthur Antolini, Flavio Araújo Borges, Junior, Mariana Lazarini, Master, Degree, Doctorate, Stude, Patricia M.B. Favaro, PhD, Leticia Fröhlich -Archangelo, PhD, Paulo C.A. Pernanbuco Filho, Adriana Silva Santos Duarte, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T.O Saad, M.D., Ph.D.

Blood (2009) 114 (22): 1779.

https://doi.org/10.1182/blood.V114.22.1779.1779

Published: 2009

Journal Articles

ANKHD1, a New Ankyrin-Repeat Protein, Binds to SIVA and May Modulate ROS Generation, Cell Cycle and Apoptosis Signaling in Cancer Cells

Fabiola Traina, MD, PhD, Patrícia Cristina Rodrigues, M.Sc., Mariana Lazarini, M.Sc., Paulo Roberto Moura Lima, PhD, Fernando F. Costa, MD, PhD, Sara T.O. Saad, MD, PhD

Blood (2008) 112 (11): 5319.

https://doi.org/10.1182/blood.V112.11.5319.5319

Published: 2008

Journal Articles

ARHGAP21 Is Overexpressed in Bone Marrow of Acute Leukemia Patients and Interacts with Focal Adhesion Kinase (FAK) in Hematopoietic Cells.

Fabiola Traina, MD, Sheila M.B. Winnischofer, PhD, Luciene Borges, Mariana Lazarini, Carolina L. Bigarella, Fernando F. Costa, MD, PhD, Sara T.O. Saad, MD, PhD

Blood (2006) 108 (11): 4450.

https://doi.org/10.1182/blood.V108.11.4450.4450

Published: 2006

NARROW

Reduction of ARHGAP21 Alters Platelet Biogenesis in Vitro and Accelerates Hemostatic Response In Vivo

ARHGAP21 Is Upregulated and Triggers the Modulation of Rho Gtpase Signaling Pathways during Megakaryocytic Differentiation

Stathmin 1 Silencing Amplifies Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

BRD4 Short Isoform Is a Myelodysplasia Prognostic Marker Involved in Inappropriate DNA Damage Response

Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis

Ndfip Is a Novel Autophagy Regulator and It Is Deregulated In Acute Myeloid Leukemia

Rhodiola Rosea Extract Reduces Autophagy In Acute Myeloid Leukemia Transformed From Myelodysplastic Syndromes Tumor Xenograft Model

Inflammasome and Autophagy Activation In Symptomatic Multiple Myeloma Could Predict Response To Thalidomide-Based Chemotherapy

Stathmin 1 Is Involved In The Highly Proliferative Phenotype Of High-Risk Myelodysplastic Syndromes and Acute Leukemia Cells

ANKHD1 Interacts with the Proapoptotic Protein SIVA and Plays a Role in the Proliferation and Stathmin Activation of Acute Leukemia Cells.

Autophagy Regulation and Dysfunction in Bone Marrow Malignancies

BNIP3 Is Downregulated in Myelodysplastic Syndromes and Acute Myeloid Leukemia and Is a Potential Molecular Target for Decitabine

Downregulation of IRS2 in Myelodysplastic Syndrome (MDS) May Be Related to Impaired Cell Differentiation,

In Vitro and In Vivo downregulation of Leukemogenesis by FMNL1 Inhibition In Namalwa Cell Line

IRS2 Is Dowregulated In Primary MDS Cells and During MDS Erythroid Differentiation

Knockdown of Insulin Receptor Substrate 1 (IRS1); a Partner of BCR-ABL, Results In Decrease In Proliferation and Downregulation of AKT/mTOR and MAPK Pathways In K562 Cells

Alpha-Catenin, ARHGAP21 and β-Catenin Are Abnormally Expressed in Bone Marrow Cells From Patients with Myelodysplatic Syndromes and Are a Possible Target for Decitabine Treatment.

IRS1 and SHP2 Signaling in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

ANKHD1, a New Ankyrin-Repeat Protein, Binds to SIVA and May Modulate ROS Generation, Cell Cycle and Apoptosis Signaling in Cancer Cells

ARHGAP21 Is Overexpressed in Bone Marrow of Acute Leukemia Patients and Interacts with Focal Adhesion Kinase (FAK) in Hematopoietic Cells.

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American Society of Hematology

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American Society of Hematology

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