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Journal Articles

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Katarzyna Sielatycka, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-137083

Published: 2020

Journal Articles

Unexpected Novel Findings That Caspase-1-KO Mice Are Poor Mobilizers and Engraft Poorly with Wild Type Bone Marrow Cells - Indicating a Presence of an Autocrine Feedback Loop Involving Interleukin 1b and Interleukin 18 Signaling That Potentiates Nlrp3 Inflammasome Activity, Both in HSPCs and in the BM Microenvironment for Optimal Stem Cell Trafficking

Arjun Thapa, Janina Ratajczak, MD PhD DSci, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-137495

Published: 2020

Journal Articles

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Arjun Thapa, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-137102

Published: 2020

Journal Articles

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Mateusz Adamiak, PhD, Arjun Thapa, Kamila Bujko, MSc, Valentina Pensato, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-137123

Published: 2020

Journal Articles

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Alison Domingues, MS, Kamila Bujko, MS, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4882.

https://doi.org/10.1182/blood-2019-125819

Published: 2019

Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4468.

https://doi.org/10.1182/blood-2019-125838

Published: 2019

Journal Articles

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Kamila Bujko, MS, Mateusz Adamiak, PhD, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4472.

https://doi.org/10.1182/blood-2019-125858

Published: 2019

Journal Articles

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Monika Cymer, MS, Mateusz Adamiak, PhD, Marta Skoda, PhD, Marta Antonina Libura, MD PhD, Elzbieta Urbanowska, PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 3248.

https://doi.org/10.1182/blood-2019-125883

Published: 2019

Journal Articles

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Mateusz Adamiak, PhD, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Marta Skoda, PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 1033.

https://doi.org/10.1182/blood-2019-125853

Published: 2019

Journal Articles

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Mateusz Adamiak, PhD, Kamila Bujko, MS, Monika Plonka, MD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 4528.

https://doi.org/10.1182/blood-2018-99-110634

Published: 2018

Journal Articles

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

Mateusz Adamiak, PhD, Kamila Bujko, MS, Anna Lenkiewicz, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSci

Blood (2018) 132 (Supplement 1): 2060.

https://doi.org/10.1182/blood-2018-99-110631

Published: 2018

Journal Articles

A Novel View of Umbilical Cord Blood Versus Maternal Peripheral Blood — Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal–Maternal Circulation Barrier.

Kasia Sielatycka, PhD, Agata Poniewierska-Baran, PhD, Karolina Nurek, MD, Andrzej Torbe, MD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 4950.

https://doi.org/10.1182/blood.V130.Suppl_1.4950.4950

Published: 2017

Journal Articles

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

Janina Ratajczak, MD PhD DSci, Malwina Suszynska, PhD, Kamila Bujko, MS, Donald M Miller, MD PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3761.

https://doi.org/10.1182/blood.V130.Suppl_1.3761.3761

Published: 2017

Journal Articles

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Ahmed Abdelbaset-Ismail, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3803.

https://doi.org/10.1182/blood.V130.Suppl_1.3803.3803

Published: 2017

Journal Articles

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

Mateusz Adamiak, PhD, Lakshman Chelvarajan, Webster Santos, PhD, Kevin R Lynch, PhD, Ahmed Abdel-Latif, MD PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 4477.

https://doi.org/10.1182/blood.V130.Suppl_1.4477.4477

Published: 2017

Journal Articles

Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria

Kamila Bujko, MS, Sylwia Rzeszotek, PhD, Janina Ratajczak, MD PhD DSci, Kai Hoehlig, PhD, Axel Vater, PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 1188.

https://doi.org/10.1182/blood.V130.Suppl_1.1188.1188

Published: 2017

Journal Articles

Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades

Mateusz Adamiak, Malwina Suszynska, PhD, Ahmed Abdel-Latif, MD PhD, Ahmed Abdelbaset-Ismail, PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3371.

https://doi.org/10.1182/blood.V128.22.3371.3371

Published: 2016

Journal Articles

Unexpected Evidence That Inducible Nitric Oxide Synthase (iNOS) Is a Negative Regulator of Hematopoietic Stem/Progenitor Cell Mobilization

Mateusz Adamiak, MS, Ahmed Abdelbaset-Ismail, PhD, Marcin Wysoczynski, PhD, Ahmed Abdel-Latif, MD PhD, Joseph B Moore, IV, MS, Janina Ratajczak, MD PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3372.

https://doi.org/10.1182/blood.V128.22.3372.3372

Published: 2016

Journal Articles

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Mateusz Adamiak, MS, Ahmed Abdelbaset Ismail, PhD, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD, Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD PhD

Blood (2016) 128 (22): 3342.

https://doi.org/10.1182/blood.V128.22.3342.3342

Published: 2016

Journal Articles

Daily Light and Darkness Signals Regulate Bone Marrow Stem Cell Development and Leukocyte Production Via Tnfα and an Interplay Between Norepinephrine and Melatonin

Karin Golan, PhD, Anju Kumari, PhD, Eman Khatib-Massalha, Msc, Sylwia Rzeszotek, PhD, Shiri Gur-Cohen, PhD, Zulma S. Ferreira, PhD, Tomer Itkin, PhD, Orit Kollet, PhD, Mariusz Z Ratajczak, MD PhD, Regina P. Markus, PhD, Tsvee Lapidot, PhD

Blood (2016) 128 (22): 721.

https://doi.org/10.1182/blood.V128.22.721.721

Published: 2016

NARROW

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Novel Evidence That Extracellular Nucleotides and Nucleosides Regulate the Expression of Heme Oxygenase 1 (HO-1) in Opposite Ways in Hematopoietic Stem/Progenitor Cells (HSPCs), Which Explains Why ATP Enhances Mobilization of HSPCs, While Its Metabolite Adenosine Inhibits This Process

Novel Evidence That the Ectonucleotidases CD39 and CD73, Which Are Expressed on Hematopoietic Stem/Progenitor Cells (HSPCs), Regulate Mobilization and Homing - Studies in CD39-/- and CD73-/- Mice and with Small-Molecule CD39 and CD73 Inhibitors

A Novel View of Umbilical Cord Blood Versus Maternal Peripheral Blood — Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal–Maternal Circulation Barrier.

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria

Novel Evidence That the Mannan-Binding Lectin (MBL) Pathway of Complement Activation Plays a Pivotal Role in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells By Activation of Both the Complement and Coagulation Cascades

Unexpected Evidence That Inducible Nitric Oxide Synthase (iNOS) Is a Negative Regulator of Hematopoietic Stem/Progenitor Cell Mobilization

Novel Evidence That Hematopoietic-Specific PLC-β2 Is Required for Normal Homing and Engraftment of Hematopoietic Stem Cells

Daily Light and Darkness Signals Regulate Bone Marrow Stem Cell Development and Leukocyte Production Via Tnfα and an Interplay Between Norepinephrine and Melatonin

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American Society of Hematology

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American Society of Hematology

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