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Journal Articles

Novel Therapeutic Rationale for Targeting HDAC1 and PIM2 in Multiple Myeloma

Takeshi Harada, MD PhD, Asuka Oda, Hiroto Ohguchi, MD PhD, Yohann Grondin, PhD, Hirofumi Tenshin, DDS, PhD, Masahiro Hiasa, DDS, PhD, Jumpei Teramachi, Masahiro Oura, MD, Kimiko Sogabe, MD, Shiro Fujii, MD PhD, Shingen Nakamura, MD PhD, Hirokazu Miki, MD PhD, Kumiko Kagawa, MD PhD, Shuji Ozaki, MD PhD, Teru Hideshima, MD PhD, Kenneth C. Anderson, MD, Masahiro Abe, MD PhD

Blood (2019) 134 (Supplement_1): 3111.

https://doi.org/10.1182/blood-2019-127679

Published: 2019

Journal Articles

Pim Inhibition Suppresses Osteoclastogenesis and Tumor Growth in Myeloma

Jumpei Teramachi, DDS, PhD, Masahiro Hiasa, PhD DDS, Asuka Oda, Hirofumi Tenshin, DDS, Ryota Amachi, DDS, PhD, Takeshi Harada, MDPhD, Derek Hanson, Keiichiro Watanabe, DDS, PhD, Shiro Fujii, MD, Kumiko Kagawa, MD, Shingen Nakamura, MD PhD, Hirokazu Miki, MD PhD, Itsuro Endo, MD PhD, Shuji Ozaki, MD PhD, Toshio Matsumoto, MD PhD, Masahiro Abe, MD PhD

Blood (2015) 126 (23): 4203.

https://doi.org/10.1182/blood.V126.23.4203.4203

Published: 2015

Journal Articles

Targeting Drug-Resistant Myeloma Cells in an Acidic Milieu by Pim Inhibition

Shiro Fujii, MD, Masami Iwasa, MD, Takeshi Harada, MD, Shingen Nakamura, MD, Hirokazu Miki, MD, PhD, Ayako Nakano, MD, PhD, Kumiko Kagawa, MD, PhD, Ryota Amachi, DDS, Keiichiro Watanabe, DDS, Masahiro Hiasa, DDS, Shuji Ozaki, MD, PhD, Toshio Matsumoto, MD, PhD, Masahiro Abe, MD, PhD

Blood (2012) 120 (21): 5011.

https://doi.org/10.1182/blood.V120.21.5011.5011

Published: 2012

Journal Articles

Potentiation of bortezomib's Anti-Myeloma Effects in Combination with Anti-DR5 Agonistic Antibody: The Role of ER Stress in DR5 Editing and DR-Mediated Apoptotic Signaling

Hirokazu Miki, MD, Masahiro Abe, MD, PhD, Kumiko Kagawa, MD, Asuka Oda, PhD, Hiroe Amou, PhD, Akishige Ikegame, PhD, Keiichiro Watanabe, DDS, Masahiro Hiasa, DDS, Takeshi Harada, MD, Shiro Fujii, MD, Shingen Nakamura, MD, Ayako Nakano, MD, PhD, Kyoko Takeuchi, MD, PhD, Shuji Ozaki, MD, PhD, Yukimasa Shiotsu, PhD, Masaki Ri, MD, Shinsuke Iida, MD, PhD, Toshio Matsumoto, MD, PhD

Blood (2011) 118 (21): 5104.

https://doi.org/10.1182/blood.V118.21.5104.5104

Published: 2011

Journal Articles

An Acidic Milieu Created In Myeloma-Osteoclast Interaction Enhances Tumor Growth, but Triggers Anti-Myeloma Activity of Reveromycin A, a Novel Anti-Resorptive Agent

Keiichiro Watanabe, DDS, Masahiro Abe, MD, PhD, Qu Cui, MD, Makoto Kawatani, PhD, Masahiro Hiasa, DDS, PhD, Ayako Nakano, MD, PhD, Tadashi Jinno, MD, Takeshi Harada, MD, Shiro Fujii, MD, Shingen Nakamura, MD, Hirokazu Miki, MD, Kumiko Kagawa, MD, Kyoko Takeuchi, MD, PhD, Shuji Ozaki, MD, PhD, Eiji Tanaka, DDS, PhD, Hiroyuki Osada, PhD, Toshio Matsumoto, MD, PhD

Blood (2010) 116 (21): 454.

https://doi.org/10.1182/blood.V116.21.454.454

Published: 2010

Journal Articles

Lenalidomide In Combination with Zoledronic Acid Restores the Activation and Anti-Myeloma Effects of γδT Cells Attenuated by the Bone Marrow Microenvironment

Qu Cui, MD, Masahiro Abe, MD, PhD, Hirokazu Miki, MD, Shingen Nakamura, MD, Keiichiro Watanabe, DDS, Akishige Ikegame, Masahiro Hiasa, DDS, PhD, Ayako Nakano, MD, PhD, Takeshi Harada, MD, Shiro Fujii, MD, Kumiko Kagawa, MD, Kyoko Takeuchi, MD, PhD, Shuji Ozaki, MD, PhD, Toshio Matsumoto, MD, PhD

Blood (2010) 116 (21): 3025.

https://doi.org/10.1182/blood.V116.21.3025.3025

Published: 2010

Journal Articles

Facilitation of Osteoblast Differentiation by ATF-4 Accumulation through Proteasome Inhibition.

Shingen Nakamura, Masahiro Abe, Qu Cui, Ayako Nakano, Asuka Oda, Hiroe Amou, Akishige Ikegame, Takeshi Harada, Masahiro Hiasa, Hirokazu Miki, Kumiko Kagawa, Kyoko Takeuchi, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto

Blood (2009) 114 (22): 1823.

https://doi.org/10.1182/blood.V114.22.1823.1823

Published: 2009

Journal Articles

GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)

Masahiro Hiasa, Masahiro Abe, Ayako Nakano, Asuka Oda, Hiroe Amou, Shinsuke Kido, Kyoko Takeuchi, Kumiko Kagawa, Kenichiro Yata, Toshihiro Hashimoto, Shuji Ozaki, Kenzo Asaoka, Eiji Tanaka, Keiji Moriyama, Toshio Matsumoto

Blood (2009) 114 (20): 4517–4526.

https://doi.org/10.1182/blood-2009-04-215020

Published: 2009

Includes: Supplemental data

Journal Articles

Anti-Myeloma Effects of γδ T Cells Are Hampered by Bone Marrow Stromal Cells but Resumed by Stromal Cell-Derived Osteoblasts.

Kenichiro Yata, Masahiro Abe, Asuka Oda, Hiroe Amou, Masahiro Hiasa, Kyoko Takeuchi, Shingen Nakamura, Osamu Tanaka, Hirokazu Miki, Ayako Nakano, Kumiko Kagawa, Shuji Ozaki, Toshio Matsumoto

Blood (2008) 112 (11): 1685.

https://doi.org/10.1182/blood.V112.11.1685.1685

Published: 2008

Journal Articles

The Serine/Threonine Kinase Pim-2 Is a Novel Anti-Apoptotic Mediator in Myeloma Cells.

Jin Asano, MD, Masahiro Abe, MD, Shiro Fujii, MD, Osamu Tanaka, MD, Ai Mihara, MD, Shingen Nakamura, MD, Kazuhiro Miki, MD, Kumiko Kagawa, MD, Kyoko Takeuchi, MD, Kenichiro Yata, MD, Toshihiro Hashimoto, MD, Shuji Ozaki, MD, Masahiro Hiasa, DDS, Toshio Matsumoto, MD

Blood (2007) 110 (11): 243.

https://doi.org/10.1182/blood.V110.11.243.243

Published: 2007

Journal Articles

Inhibition of TACE Activity Enhances the Susceptibility of Myeloma Cells to TRAIL.

Kumiko Kagawa, MD, Masahiro Abe, MD, Shiro Fujii, MD, Osamu Tanaka, MD, Ai Mihara, MD, Shingen Nakamura, MD, Kazuhiro Miki, MD, Jin Asano, MD, Kyoko Takeuchi, MD, Kenichiro Yata, MD, Toshihiro Hashimoto, MD, Shuji Ozaki, MD, Masahiro Hiasa, DDS, Toshio Matsumoto, MD

Blood (2007) 110 (11): 244.

https://doi.org/10.1182/blood.V110.11.244.244

Published: 2007

Journal Articles

SB431542, a TGF-Beta Receptor Kinase Inhibitor, Restores Bone Formation Which Ameliorates Myeloma-Induced Microenvironment.

Kyoko Takeuchi, MD, Masahiro Abe, MD, Asuka Oda, MT, Hiroe Amou, MT, Masahiro Hiasa, DDS, Jin Asano, MD, Kenichi Kitazoe, MD, Toshihiro Hashimoto, MD, Shuji Ozaki, MD, Shinsuke Kido, PhD, Daisuke Inoue, MD, Toshio Matsumoto, MD

Blood (2006) 108 (11): 3479.

https://doi.org/10.1182/blood.V108.11.3479.3479

Published: 2006

Journal Articles

Emerging of Valproic Acid as an Anti-Myeloma Agent.

Kenichi Kitazoe, MD, Masahiro Abe, MD, Masahito Choraku, MD, Kumiko Kagawa, MD, Jin Asano, MD, Kyoko Takeuchi, MD, Masahiro Hiasa, DDS, Toshihiro Hashimoto, MD, Shuji Ozaki, MD, Asuka Oda, MT, Hiroe Amou, MT, Toshio Matsumoto, MD

Blood (2006) 108 (11): 3482.

https://doi.org/10.1182/blood.V108.11.3482.3482

Published: 2006

Journal Articles

Angiogenesis and Osteoclastogenesis Are Mutually Stimulated in Myeloma: A Role for VEGF and Osteopontin.

Yoichi Tanaka, Masahiro Abe, Masahiro Hiasa, Toshihiro Hashimoto, Shinsuke Kido, Daisuke Inoue, Shuji Ozaki, Keiji Moriyama, Toshio Matsumoto

Blood (2005) 106 (11): 2500.

https://doi.org/10.1182/blood.V106.11.2500.2500

Published: 2005

NARROW

Novel Therapeutic Rationale for Targeting HDAC1 and PIM2 in Multiple Myeloma

Pim Inhibition Suppresses Osteoclastogenesis and Tumor Growth in Myeloma

Targeting Drug-Resistant Myeloma Cells in an Acidic Milieu by Pim Inhibition

Potentiation of bortezomib's Anti-Myeloma Effects in Combination with Anti-DR5 Agonistic Antibody: The Role of ER Stress in DR5 Editing and DR-Mediated Apoptotic Signaling

An Acidic Milieu Created In Myeloma-Osteoclast Interaction Enhances Tumor Growth, but Triggers Anti-Myeloma Activity of Reveromycin A, a Novel Anti-Resorptive Agent

Lenalidomide In Combination with Zoledronic Acid Restores the Activation and Anti-Myeloma Effects of γδT Cells Attenuated by the Bone Marrow Microenvironment

Facilitation of Osteoblast Differentiation by ATF-4 Accumulation through Proteasome Inhibition.

GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)

Anti-Myeloma Effects of γδ T Cells Are Hampered by Bone Marrow Stromal Cells but Resumed by Stromal Cell-Derived Osteoblasts.

The Serine/Threonine Kinase Pim-2 Is a Novel Anti-Apoptotic Mediator in Myeloma Cells.

Inhibition of TACE Activity Enhances the Susceptibility of Myeloma Cells to TRAIL.

SB431542, a TGF-Beta Receptor Kinase Inhibitor, Restores Bone Formation Which Ameliorates Myeloma-Induced Microenvironment.

Emerging of Valproic Acid as an Anti-Myeloma Agent.

Angiogenesis and Osteoclastogenesis Are Mutually Stimulated in Myeloma: A Role for VEGF and Osteopontin.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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