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Journal Articles

Fibrinogen Activates FAK to Promote the Colorectal Adenocarcinoma Growth

Balkrishan Sharma, PhD, Duaa Mureb, BS, Sumit Murab, PhD, Leah A. Rosenfeldt, BS, Brenton J Francisco, MD, Alexander A Boucher, MD, Rachel Cantrell, BS, Jacob Mast, Matthew J. Flick, PhD, Patrick W Whitlock, MD, Joseph S. Palumbo, MD

Blood (2019) 134 (Supplement_1): 1111.

https://doi.org/10.1182/blood-2019-130497

Published: 2019

Journal Articles

A Human Fibrinogen Variant with Impaired Staphylococcus Aureus Binding Function Promotes Host Survival during Septicemia in Mice

Oscar Negron, Jaap Koopman, PhD, Miranda Weggeman, PhD, Linda Huisman, PhD, Amanda Stang, Matthew J. Flick, PhD

Blood (2018) 132 (Supplement 1): 3775.

https://doi.org/10.1182/blood-2018-99-118491

Published: 2018

Journal Articles

Diminished Renal Pathology in a Mouse Model of Sickle Cell Anemia in Which Fibrinogen Binding to Mac-1 Is Inhibited

Md Nasimuzzaman, PhD, Paritha I. Arumugam, PhD, Eric S. Mullins, MD, Jeanne M James, MD, Katherine VandenHeuvel, MD, Marilou Narciso, BS, Maureen A. Shaw, MSc, Sarah McGraw, Bruce J. Aronow, PhD, Matthew J. Flick, PhD, Punam Malik, MD

Blood (2018) 132 (Supplement 1): 267.

https://doi.org/10.1182/blood-2018-99-112641

Published: 2018

Journal Articles

Plasmin-Mediated Fibrinolysis Enables Macrophage Migration Via Liberation from Fibrin-α M β 2 Interactions

Eric S. Mullins, MD, Maureen A. Shaw, MSc, Zhen Gao, PhD, Matthew J. Flick, PhD

Blood (2018) 132 (Supplement 1): 136.

https://doi.org/10.1182/blood-2018-99-117018

Published: 2018

Journal Articles

Inflammation and Tissue Damage Mediated By PAR-1 Expression Is Cell Type-Specific and Varies Depending on the Inflammatory Challenge

Alexander A Boucher, MD, Leah A. Rosenfeldt, BS, Duaa Mureb, BS, Anna K Kopec, PhD, James P. Luyendyk, PhD, Matthew J. Flick, PhD, Joseph S. Palumbo, MD

Blood (2018) 132 (Supplement 1): 133.

https://doi.org/10.1182/blood-2018-99-117312

Published: 2018

Journal Articles

Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis

Allison S. Remiker, MD, Leah A. Rosenfeldt, BS, Greg N. Adams, PhD, Matthew J. Flick, PhD, Malinda D. Frederick, BS, Joseph S. Palumbo, MD

Blood (2017) 130 (Supplement 1): 1063.

https://doi.org/10.1182/blood.V130.Suppl_1.1063.1063

Published: 2017

Journal Articles

Fibrin(ogen)-Pathogen Interactions Support Antimicrobial Host Defense Following Staphylococcus Aureus Peritonitis Infection

Oscar Negron, Carolina Cruz, Matthew J. Flick, PhD

Blood (2017) 130 (Supplement 1): 2350.

https://doi.org/10.1182/blood.V130.Suppl_1.2350.2350

Published: 2017

Journal Articles

Mice Lacking Factor XIII Have Significant Protection from the Progression of Neuroinflammatory Disease

Zhen Gao, PhD, Maureen A. Shaw, MSc, Joseph S. Palumbo, MD, Matthew J. Flick, PhD, Eric S. Mullins, MD

Blood (2017) 130 (Supplement 1): 237.

https://doi.org/10.1182/blood.V130.Suppl_1.237.237

Published: 2017

Journal Articles

Tumor Cell Thrombin/PAR-1 Signaling Drives Pancreatic Ductal Adenocarcinoma Growth and Dissemination

Matthew J. Flick, PhD, Cheryl Rewerts, M.S., Carolina Cruz, Joseph S. Palumbo, MD, James P. Luyendyk, PhD, Yi Yang, Stephen F. Konieczny, PhD

Blood (2015) 126 (23): 1070.

https://doi.org/10.1182/blood.V126.23.1070.1070

Published: 2015

Journal Articles

Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis

Sherry Thornton, PhD, Harini Raghu, PhD, Alice Jone, BS, Carolina Cruz, BS, Cheryl L. Rewerts, MS, Malinda D. Frederick, Jay L. Degen, PhD, Matthew J. Flick, PhD

Blood (2014) 124 (21): 580.

https://doi.org/10.1182/blood.V124.21.580.580

Published: 2014

Journal Articles

Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi,

Maria M. Aleman, BS, James R. Byrnes, BS, Jianguo Wang, PhD, Nigel Mackman, PhD, Jay L. Degen, PhD, Matthew J Flick, PhD, Alisa S. Wolberg, PhD

Blood (2013) 122 (21): 451.

https://doi.org/10.1182/blood.V122.21.451.451

Published: 2013

Journal Articles

PAR-1 Is a Context Dependent Determinant of Colitis and Colitis-Associated Cancer.

Brian K. Turpin, DO, Kris Steinbrecher, PhD, Maureen Shaw, Kathryn E McElhinney, Richard Baylis, Matthew J. Flick, PhD, Whitney M Miller, Joseph S. Palumbo, MD

Blood (2012) 120 (21): 2221.

https://doi.org/10.1182/blood.V120.21.2221.2221

Published: 2012

Journal Articles

Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Eric S. Mullins, MD, Maureen A. Shaw, M.S, Kathryn E. McElhinney, Keith W. Kombrinck, M.S., Matthew J. Flick, PhD, Alexander Brill, MD, PhD, Denisa D. Wagner, PhD, Jay L. Degen, PhD

Blood (2012) 120 (21): 496.

https://doi.org/10.1182/blood.V120.21.496.496

Published: 2012

Journal Articles

Plasminogen Mediates Both Positive and Negative Effects on Disease Severity in a Mouse Model of TNFα-Driven Arthritis

Harini Raghu, Malinda D. Frederick, Alice Jone, Kathryn E. Talmage, Keith W. Kombrinck, Matthew J. Flick, PhD

Blood (2011) 118 (21): 854.

https://doi.org/10.1182/blood.V118.21.854.854

Published: 2011

Journal Articles

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Brian K. Turpin, DO, Whitney M Miller, Eric S. Mullins, MD, Jay L. Degen, PhD, Matthew J. Flick, PhD, Brett P. Monia, PhD, Robert MacLeod, Ph.D., Alexey S Revenko, PhD, Joseph S. Palumbo, MD

Blood (2011) 118 (21): 2237.

https://doi.org/10.1182/blood.V118.21.2237.2237

Published: 2011

Journal Articles

Host Prothrombin and Fibrinogen Support S. Aureus Virulence In the Context of Acute Bacteremia

Matthew J. Flick, PhD, Xinli Du, PhD, Leslie Fausnacht, Harini Raghu, Kathryn E Talmage, Keith W Kombrinck, Elizabeth A. Blevins, Eric S. Mullins, MD, Joseph S. Palumbo, MD, Jay L. Degen, PhD

Blood (2010) 116 (21): 821.

https://doi.org/10.1182/blood.V116.21.821.821

Published: 2010

Journal Articles

Host Fibrinogen and the S. Aureus -Encoded Procoagulant Vwbp Are Context-Dependent Determinants of Bacterial Virulence.

Joni M Prasad, Xinli Du, MD, PhD, Eric S. Mullins, MD, Senad Divanovic, PhD, Kathryn E Talmage, Keith W Kombrinck, Alice G Cheng, Olaf Schneewind, MD, PhD, Matthew J. Flick, PhD, Jay L. Degen, PhD

Blood (2010) 116 (21): 1152.

https://doi.org/10.1182/blood.V116.21.1152.1152

Published: 2010

Journal Articles

The Virulence of S. Aureus Is Supported by Host Fibrinogen and Its Bacterial Receptor ClfA in the Context of Bacteremia.

Matthew J Flick, PhD, Xinli Du, Kathryn E. Talmage, Keith W. Kombrink, Elizabeth A. Blevins, Joseph S. Palumbo, MD, Jay L Degen, PhD

Blood (2009) 114 (22): 3188.

https://doi.org/10.1182/blood.V114.22.3188.3188

Published: 2009

Journal Articles

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Hong Yang, MD, Sean Lang, BSc, Zhimin Zhai, MD, Christopher M. Spring, MSc, Adili Reheman, MD, Pingguo Chen, PhD, Matthew J. Flick, PhD, Jay L. Degen, PhD, Ling Li, MSc, Walter H.A. Kahr, MD, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2008) 112 (11): 2868.

https://doi.org/10.1182/blood.V112.11.2868.2868

Published: 2008

Journal Articles

Mice Engineered To Express a Form of Thrombin Favoring Protein C Are Resistant to S. aureus -Induced Sepsis.

Matthew J. Flick, PhD, Anil K. Chauhan, PhD, Sara Welch, BS, Maureen A. Shaw, BS, Kathryn E. Talmage, BS, Eric S. Mullins, MD, Joseph S. Palumbo, MD, Sherry Thornton, PhD, Denisa D. Wagner, PhD, Jay L. Degen, PhD

Blood (2007) 110 (11): 267.

https://doi.org/10.1182/blood.V110.11.267.267

Published: 2007

NARROW

Fibrinogen Activates FAK to Promote the Colorectal Adenocarcinoma Growth

A Human Fibrinogen Variant with Impaired Staphylococcus Aureus Binding Function Promotes Host Survival during Septicemia in Mice

Diminished Renal Pathology in a Mouse Model of Sickle Cell Anemia in Which Fibrinogen Binding to Mac-1 Is Inhibited

Plasmin-Mediated Fibrinolysis Enables Macrophage Migration Via Liberation from Fibrin-α M β 2 Interactions

Inflammation and Tissue Damage Mediated By PAR-1 Expression Is Cell Type-Specific and Varies Depending on the Inflammatory Challenge

Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis

Fibrin(ogen)-Pathogen Interactions Support Antimicrobial Host Defense Following Staphylococcus Aureus Peritonitis Infection

Mice Lacking Factor XIII Have Significant Protection from the Progression of Neuroinflammatory Disease

Tumor Cell Thrombin/PAR-1 Signaling Drives Pancreatic Ductal Adenocarcinoma Growth and Dissemination

Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis

Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi,

PAR-1 Is a Context Dependent Determinant of Colitis and Colitis-Associated Cancer.

Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Plasminogen Mediates Both Positive and Negative Effects on Disease Severity in a Mouse Model of TNFα-Driven Arthritis

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Host Prothrombin and Fibrinogen Support S. Aureus Virulence In the Context of Acute Bacteremia

Host Fibrinogen and the S. Aureus -Encoded Procoagulant Vwbp Are Context-Dependent Determinants of Bacterial Virulence.

The Virulence of S. Aureus Is Supported by Host Fibrinogen and Its Bacterial Receptor ClfA in the Context of Bacteremia.

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Mice Engineered To Express a Form of Thrombin Favoring Protein C Are Resistant to S. aureus -Induced Sepsis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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