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Meltem Isik
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Journal Articles

Knock out of CD123 or CLL-1 By CRISPR-Cas9 Editing from Human Hematopoietic Stem Cell Transplants Provide New Possibilities for Increasing Therapeutic Index and Safety for AML Treatment

Chong Luo, Gabriella Angelini, Sushma Krishnamurthy, Jessica Lisle, Meltem Isik, Azita Ghdossi, Christopher Cummins, Michael Pettiglio, Dane Hazelbaker, Gary Ge, Patrick Tavares, Mugdha Nikam, Elizabeth Paik, John Lydeard, Michelle Lin, Tirtha Chakraborty
Journal: Blood
Blood (2021) 138 (Supplement 1): 3818.
https://doi.org/10.1182/blood-2021-146235
Published: 2021
Journal Articles

Multiplex Engineering of Human CD34+ HSPCs Enables Dual Gene Knock-out While Maintaining High Engraftment Potential and Safety

Nipul Patel, Michael Pettiglio, Christopher Cummins, Jeff Pimentel, Anjali Kapuria, Azita Ghodssi, Meltem Isik, Alejandra Falla, Ravindra Amunugama, Jessica Lisle, Shu Wang, Michelle Lin, John Lydeard, Gary Ge, Dane Hazelbaker, Elizabeth Paik, Tirtha Chakraborty
Journal: Blood
Blood (2021) 138 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2021-148007
Published: 2021
Journal Articles

Comparative Studies Reveal Robust HbF Induction By Editing of HBG1/2 Promoters or BCL11A Erythroid-Enhancer in Human CD34+ Cells but That BCL11A Erythroid-Enhancer Editing Is Associated with Selective Reduction in Erythroid Lineage Reconstitution in a Xenotransplantation Model

Kai-Hsin Chang, PhD, Minerva Sanchez, Jack Heath, Edouard deDreuzy, PhD, Scott Haskett, MS, Abigail Vogelaar, Kiran Gogi, Jen Da Silva, Tongyao Wang, Andrew Sadowski, Gregory Gotta, Jamaica Siwak, Ramya Viswanathan, Katherine Loveluck, Hoson Chao, Eric Tillotson, Aditi Chalishazar, MS, Abhishek Dass, Frederick Ta, Emily Brennan, Diana Tabbaa, Eugenio Marco, PhD, John A Zuris, PhD, Deepak Reyon, PhD, Meltem Isik, PhD, Ari Friedland, PhD, Terence Ta, PhD, Fred Harbinski, Georgia Giannoukos, PhD, Sandra Teixeira, PhD, Christopher J Wilson, PhD, Charlie Albright, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 409.
https://doi.org/10.1182/blood-2018-99-114780
Published: 2018