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Journal Articles

The Effect of Neutrophil Elastase Inhibitors on in-Vitro Myeloid Differentiation of CD34+ Cells of Patients with ELANE Associated Neutropenia

Vahagn Makaryan, Merideth L. Kelley, David C. Dale

Blood (2022) 140 (Supplement 1): 2617.

https://doi.org/10.1182/blood-2022-159206

Published: 2022

Journal Articles

Novel TCIRG1 Mutations Causing Congenital Neutropenia

Vahagn Makaryan, Merideth L. Kelley, Audrey Anna Bolyard, Hsiu-Ju Yen, David C. Dale

Blood (2022) 140 (Supplement 1): 8334–8335.

https://doi.org/10.1182/blood-2022-159214

Published: 2022

Journal Articles

The Morphologic Spectrum of Myelokathexis in WHIM Syndrome and Germline CXCR4 Variants: New Insights into Cellular Changes in the Bone Marrow and Peripheral Blood

Blood (2022) 140 (Supplement 1): 5487–5489.

https://doi.org/10.1182/blood-2022-155692

Published: 2022

Journal Articles

Heterozygous variants of CLPB are a cause of severe congenital neutropenia

Julia T. Warren, Ryan R. Cupo, Peeradol Wattanasirakul, David H. Spencer, Adam E. Locke, Vahagn Makaryan, Audrey Anna Bolyard, Merideth L. Kelley, Natalie L. Kingston, James Shorter, Christine Bellanné-Chantelot, Jean Donadieu, David C. Dale, Daniel C. Link

Blood (2022) 139 (5): 779–791.

https://doi.org/10.1182/blood.2021010762

Published: 2022

Includes: Supplemental data

Journal Articles

Spectrum of Pathogenic Genetic Variants in a Large Cohort of North American Congenital and Cyclic Neutropenia Patients: A Report from the Severe Chronic Neutropenia International Registry

Julia T Warren, Audrey Anna Bolyard, Merideth L. Kelley, Vahagn Makaryan, David C. Dale, Daniel C. Link

Blood (2021) 138 (Supplement 1): 2059.

https://doi.org/10.1182/blood-2021-153783

Published: 2021

Journal Articles

CRISPR/Cas9 Mediated ELANE Knock-out Restores Survival and Granulocytic Differentiation of HL60 Cells Expressing Mutant Neutrophil Elastase: Is Neutrophil Elastase a Dispensible Granulocyte Protease?

Vahagn Makaryan, MD, Isabella N. Archibald, Merideth L. Kelley, MS, Breanna Fletcher, BSc, David C. Dale, MD

Blood (2019) 134 (Supplement_1): 435.

https://doi.org/10.1182/blood-2019-124988

Published: 2019

Journal Articles

Family Studies of Whim Syndrome

David C. Dale, MD, Emily Dick, BA, Merideth L. Kelley, MSc, Vahagn Makaryan, MD, Jim Connelly, MD, Audrey Anna Bolyard, RN, BS

Blood (2019) 134 (Supplement_1): 215.

https://doi.org/10.1182/blood-2019-126234

Published: 2019

Journal Articles

CRISPR/Cas9 Knock-in HL60 Cells Closely Simulate Cellular and Functional Abnormalities of ELANE associated Neutropenia; Phenotype Rescue with MK-0339 Neutrophil Elastase Inhibitor

Vahagn Makaryan, MD, Breanna Fletcher, BSc, Merideth L. Kelley, MSc, Masoud Nasri, Julia Skokowa, MD PhD, Karl Welte, David C Dale, MD

Blood (2018) 132 (Supplement 1): 3683.

https://doi.org/10.1182/blood-2018-99-113054

Published: 2018

Journal Articles

Determination of Phase 3 Dose for X4P-001 in Patients with WHIM Syndrome

David C Dale, MD, Frank Caleb Firkin, MD, Audrey Anna Bolyard, RN, BS, Merideth L. Kelley, MSc, Emily Dick, BA, Sonja Hartmann, PhD, Karen Brown, PhD, Tarek M Ebrahim, MD, Kenneth J Gorelick, MD, Sudha Parasuraman, MD

Blood (2018) 132 (Supplement 1): 1102.

https://doi.org/10.1182/blood-2018-99-119840

Published: 2018

Journal Articles

A Novel Device Suitable for Home Monitoring of White Blood Cell and Neutrophil Counts

David C Dale, MD, Merideth L. Kelley, MSc, Myriam Navarro-De La Vega, Dhruv Parthasarathy, Deepika Bodapati, Louis Virey, MSc, Steve Moffatt, BSc, Tanay Tandon

Blood (2018) 132 (Supplement 1): 1103.

https://doi.org/10.1182/blood-2018-99-112647

Published: 2018

Journal Articles

The Effect of the MK0339 Neutrophil Elastase Inhibitor on Proliferation and Maturation of iPSC Derived from Patients with ELANE, TCIRG1 and Whim Syndrome Associated Neutropenia

Vahagn Makaryan, MD, Breanna Fletcher, BSc, Merideth L. Kelley, MS, David Dale, MD

Blood (2017) 130 (Supplement 1): 545.

https://doi.org/10.1182/blood.V130.Suppl_1.545.545

Published: 2017

Journal Articles

X4P-001: A Novel Molecularly-Targeted Oral Therapy for Whim Syndrome

David Dale, MD, Audrey Anna Bolyard, RN, BS, Emily Dick, BA, Merideth L. Kelley, MS, Vahagn Makaryan, MD, Ramsey Johnson, MSM, Lu Gan, MD PhD, Sudha Parasuraman, MD

Blood (2017) 130 (Supplement 1): 995.

https://doi.org/10.1182/blood.V130.Suppl_1.995.995

Published: 2017

Journal Articles

Termination and Frameshift Mutations in ELANE Are Associated with Adverse Outcomes in Patients with Severe Chronic Neutropenia

David C. Dale, MD, Vahagn Makaryan, MD, Merideth L. Kelley, MS, Audrey Anna Bolyard, RN, BS, Laurence A. Boxer, MD, Peter E. Newburger, MD, Mary Ann Bonilla, MD, Maksim Klimiankou, PhD, Julia Skokowa, MD PhD, Cornelia Zeidler, MD MPH, Karl Welte, MD

Blood (2016) 128 (22): 1326.

https://doi.org/10.1182/blood.V128.22.1326.1326

Published: 2016

Journal Articles

TCIRG1 Mutations As a Cause for Chronic Neutropenia

Vahagn Makaryan, MD, Breanna Fletcher, BSc, Merideth L. Kelley, MS, Audrey Anna Bolyard, RN, BS, Daniel C. Link, MD, Eric J. Duncavage, MD, David Augustus Qualls, MD, David C. Dale, MD

Blood (2016) 128 (22): 2511.

https://doi.org/10.1182/blood.V128.22.2511.2511

Published: 2016

Journal Articles

The Effects of the Neutrophil Elastase Inhibitors MK0339 and Sivelestat on the Survival, Proliferation and Maturation of iPSC and HL60 Cells Expressing Mutant Neutrophil Elastase

Vahagn Makaryan, MD, Merideth L. Kelley, MS, Breanna Fletcher, BSc, David C. Dale, MD

Blood (2016) 128 (22): 406.

https://doi.org/10.1182/blood.V128.22.406.406

Published: 2016

Journal Articles

Long Term Outcomes for Patients with Cyclic Neutropenia Treated with Granulocyte Colony-Stimulating Factor (G-CSF)

David C. Dale, MD, Audrey Anna Bolyard, RN, BS, Merideth L. Kelley, MS, Vahagn Makaryan, MD, Mary Ann Bonilla, MD, Laurence A. Boxer, MD, Sabine Mellor-Heineke, MD, Karl H. Welte, Prof, Dr, MD, Peter E. Newburger, MD, Cornelia Zeidler, MD MPH

Blood (2015) 126 (23): 996.

https://doi.org/10.1182/blood.V126.23.996.996

Published: 2015

Journal Articles

Neutropenia In Glycogen Storage Disease 1b (GSD1b)

David C. Dale, MD, Audrey Anna Bolyard, RN, BS, Tracy M. Marrero, Merideth L. Kelley, MS, BS, Lan Phan, BA, Laurence A. Boxer, MD, Priya S. Kishnani, MD, MB, Joanne Kurtzberg, MD, David A. Weinstein, MD, MMSc

Blood (2013) 122 (21): 2265.

https://doi.org/10.1182/blood.V122.21.2265.2265

Published: 2013

Journal Articles

TCIRG1 Associated Congenital Neutropenia

Vahagn Makaryan, MD, Elisabeth Rosenthal, PhD, Audrey Anna Bolyard, RN, BS, Merideth L. Kelley, MS, BS, Jennifer Below, PhD, Michael Bamshad, MD, Kathryn M. Bofferding, BS, Joshua D. Smith, Kati Buckingham, BS, Laurence A. Boxer, MD, Julia Skokowa, Karl Welte, Deborah A. Nickerson, PhD, Gail P. Jarvik, MD, PhD, David C. Dale, MD, For the UW Center for Mendelian Genomics

Blood (2013) 122 (21): 440.

https://doi.org/10.1182/blood.V122.21.440.440

Published: 2013

Journal Articles

Clinical Outcomes for Patients with Severe Chronic Neutropenia Due to Mutations in the Gene for Neutrophil Elastase, ELANE

Vahagn Makaryan, MD, Cornelia Zeidler, MD, Audrey Anna Bolyard, RN, BS, Julia Skokowa, MD, PhD, Merideth L. Kelley, BS, Laurence A. Boxer, MD, Mary Ann Bonilla, MD, Peter E. Newburger, MD, Akiko Shimamura, MD, PhD, Karl Welte, MD, David C. Dale, MD, for The Severe Chronic Neutropenia International Registry and Repository

Blood (2012) 120 (21): 3275.

https://doi.org/10.1182/blood.V120.21.3275.3275

Published: 2012

Journal Articles

ELANE Mutations in Cyclic and Congenital Neutropenia: Genotype-Phenotype Relationships,

David C. Dale, MD, Vahagn Makaryan, MD, Audrey Anna Bolyard, RN, BS, Elin R. Rodger, BS, RMT, Merideth L. Kelley, BS, Tracy M. Marrero, Lan Phan, BA, Andrew A Aprikyan, PhD, Mary Ann Bonilla, MD, Peter E. Newburger, MD, Laurence A. Boxer, MD, Daniel Link, MD

Blood (2011) 118 (21): 3398.

https://doi.org/10.1182/blood.V118.21.3398.3398

Published: 2011

NARROW

The Effect of Neutrophil Elastase Inhibitors on in-Vitro Myeloid Differentiation of CD34+ Cells of Patients with ELANE Associated Neutropenia

Novel TCIRG1 Mutations Causing Congenital Neutropenia

The Morphologic Spectrum of Myelokathexis in WHIM Syndrome and Germline CXCR4 Variants: New Insights into Cellular Changes in the Bone Marrow and Peripheral Blood

Heterozygous variants of CLPB are a cause of severe congenital neutropenia

Spectrum of Pathogenic Genetic Variants in a Large Cohort of North American Congenital and Cyclic Neutropenia Patients: A Report from the Severe Chronic Neutropenia International Registry

CRISPR/Cas9 Mediated ELANE Knock-out Restores Survival and Granulocytic Differentiation of HL60 Cells Expressing Mutant Neutrophil Elastase: Is Neutrophil Elastase a Dispensible Granulocyte Protease?

Family Studies of Whim Syndrome

CRISPR/Cas9 Knock-in HL60 Cells Closely Simulate Cellular and Functional Abnormalities of ELANE associated Neutropenia; Phenotype Rescue with MK-0339 Neutrophil Elastase Inhibitor

Determination of Phase 3 Dose for X4P-001 in Patients with WHIM Syndrome

A Novel Device Suitable for Home Monitoring of White Blood Cell and Neutrophil Counts

The Effect of the MK0339 Neutrophil Elastase Inhibitor on Proliferation and Maturation of iPSC Derived from Patients with ELANE, TCIRG1 and Whim Syndrome Associated Neutropenia

X4P-001: A Novel Molecularly-Targeted Oral Therapy for Whim Syndrome

Termination and Frameshift Mutations in ELANE Are Associated with Adverse Outcomes in Patients with Severe Chronic Neutropenia

TCIRG1 Mutations As a Cause for Chronic Neutropenia

The Effects of the Neutrophil Elastase Inhibitors MK0339 and Sivelestat on the Survival, Proliferation and Maturation of iPSC and HL60 Cells Expressing Mutant Neutrophil Elastase

Long Term Outcomes for Patients with Cyclic Neutropenia Treated with Granulocyte Colony-Stimulating Factor (G-CSF)

Neutropenia In Glycogen Storage Disease 1b (GSD1b)

TCIRG1 Associated Congenital Neutropenia

Clinical Outcomes for Patients with Severe Chronic Neutropenia Due to Mutations in the Gene for Neutrophil Elastase, ELANE

ELANE Mutations in Cyclic and Congenital Neutropenia: Genotype-Phenotype Relationships,

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American Society of Hematology

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American Society of Hematology

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