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Journal Articles

Human Prothrombin Variants with Modifications in the Active Site S4 Subpocket Demonstrate Resistance to Dabigatran

Viola J.F. Strijbis, Ka Lei Cheung, Tessa A. Rutten, Pieter H. Reitsma, Daniel Verhoef, Mettine H.A. Bos
Journal: Blood
Blood (2021) 138 (Supplement 1): 439.
https://doi.org/10.1182/blood-2021-150212
Published: 2021
Journal Articles

Efficacy and Safety of Recombinant Factor IX-FIAV and Bypassing Agents in Thrombin Generation Analyses in Hemophilia A Patient Plasma: The FIVITAS Study

Lorenzo G.R. Romano, Viola J.F. Strijbis, Ka Lei Cheung, Ying Poi Liu, Andrew C. McCreary, Frank W.G. Leebeek, Mettine H.A. Bos
Journal: Blood
Blood (2021) 138 (Supplement 1): 3192.
https://doi.org/10.1182/blood-2021-150492
Published: 2021
Journal Articles

Evaluation of a Blood Coagulation Factor IX Variant That Functions Independently of Factor VIII As an Alternative Treatment for Hemophilia A

Viola J.F. Strijbis, MSc, Ka Lei Cheung, Pavlina Konstantinova, PhD, Ying Poi Liu, PhD, Sander J van Deventer, MD PhD, Mettine H.A. Bos, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1110.
https://doi.org/10.1182/blood-2019-124120
Published: 2019
Journal Articles

Phe174-Mutated Human Factor X As Bypassing Agent to the Direct FXa Inhibitors

Mark Schreuder, MD, Daniel Verhoef, MSc, Ka Lei Cheung, Koen Visscher, MSc, Daan Geerke, PhD, Pieter H. Reitsma, PhD, Mettine H.A. Bos, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 363.
https://doi.org/10.1182/blood.V130.Suppl_1.363.363
Published: 2017
Journal Articles

Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors

Daniël Verhoef, Mark Schreuder, Ka Lei Cheung, Pieter H. Reitsma, Mettine H.A. Bos, PhD
Journal: Blood
Blood (2015) 126 (23): 126.
https://doi.org/10.1182/blood.V126.23.126.126
Published: 2015
Journal Articles

Modulating the Factor V Procofactor to Cofactor Transition Using Recombinant B-Domain Fragments

Matthew W Bunce, PhD, Mettine H.A. Bos, PhD, Rodney M. Camire, PhD
Journal: Blood
Blood (2011) 118 (21): 376.
https://doi.org/10.1182/blood.V118.21.376.376
Published: 2011
Journal Articles

Molecular Mechanism Underlying the Need for Three Cleavage Sites within the B-Domain to Activate Factor V by Thrombin

Roisin Walshe, BS, Mettine H.A. Bos, PhD, Rodney M. Camire, PhD
Journal: Blood
Blood (2010) 116 (21): 2219.
https://doi.org/10.1182/blood.V116.21.2219.2219
Published: 2010
Journal Articles

Conserved Structural Motifs Cooperate to Maintain Blood Coagulation Factor V in An Inactive Procofactor State.

Mettine H.A. Bos, Ph.D., Rodney M. Camire, PhD
Journal: Blood
Blood (2009) 114 (22): 850.
https://doi.org/10.1182/blood.V114.22.850.850
Published: 2009
Journal Articles

Evolutionary Adaptation of Factor V from the Venom of the Common Brown Snake into a Potent Procoagulant

Mettine H.A. Bos, Ph.D., Michael Boltz, Liam St. Pierre, Ph.D., John de Jersey, Ph.D., Paul P Masci, Ph.D., Martin L Lavin, Ph.D., Rodney M. Camire, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 586.
https://doi.org/10.1182/blood.V112.11.586.586
Published: 2008
Journal Articles

Venom-Derived Factor V from the Common Brown Snake P. Textilis Is Expressed as a Constitutively Active Cofactor.

Mettine H.A. Bos, PhD, Michael Boltz, Liam St. Pierre, PhD, Martin F. Lavin, PhD, Rodney M. Camire, PhD
Journal: Blood
Blood (2007) 110 (11): 1765.
https://doi.org/10.1182/blood.V110.11.1765.1765
Published: 2007
Journal Articles

Destabilization of the Factor V B-Domain Results in Procofactor Activation.

Rodney M. Camire, PhD, Hua Zhu, B.A., Mettine H.A. Bos, Ph.D., Raffaella Toso, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 198.
https://doi.org/10.1182/blood.V108.11.198.198
Published: 2006