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Journal Articles

Dynamics of Telomere Length Reflect the Clonal Suppression Seen with the Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia

Monika Haubitz, PhD, Elisabeth Oppliger Leibundgut, PharmD, Ingrid Helsen, Dania Hiltbrunner, Bart Burington, PhD, Oliver G. Ottmann, MD, Gary Spitzer, MD, Olatoyosi Odenike, MD, Michael A McDevitt, MD PhD, Alexander Röth, MD, David S. Snyder, MD, Gabriela M. Baerlocher, MD

Blood (2016) 128 (22): 1938.

https://doi.org/10.1182/blood.V128.22.1938.1938

Published: 2016

Journal Articles

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Leukemias

Blood (2015) 126 (23): 1361.

https://doi.org/10.1182/blood.V126.23.1361.1361

Published: 2015

Journal Articles

The JAK2 V617F Stem Cell Burden Is Mosaic, Dynamic and Correlates with Clinical Disease Burden in the MPN: An Exploitable Target

Alison R Moliterno, MD, Donna Marie Williams, PhD, Jonathan M. Gerber, MD, Michael A McDevitt, MD PhD, Ophelia Rogers, Jerry L. Spivak, MD

Blood (2015) 126 (23): 4090.

https://doi.org/10.1182/blood.V126.23.4090.4090

Published: 2015

Journal Articles

Dynamics of Mutations in Patients with ET Treated with Imetelstat

Elisabeth Oppliger Leibundgut, PharmD, Monika Haubitz, PhD, Bart Burington, PhD, Oliver G. Ottmann, MD, Gary Spitzer, MD, Olatoyosi Odenike, MD, Michael A McDevitt, MD PhD, Alexander Roeth, MD, David S. Snyder, MD, Gabriela M. Baerlocher, MD

Blood (2015) 126 (23): 57.

https://doi.org/10.1182/blood.V126.23.57.57

Published: 2015

Journal Articles

Essential Thrombocytosis: Redefinition in the Genomic Era

Donna M. Williams, PhD, Michael A McDevitt, MD PhD, Brady L Stein, MDMHS, Ophelia Rogers, Michael B. Streiff, MD, David Neal, Sophie Lanzkron, MD MHS, Linda M. S. Resar, MD, Christine O'Keefe, PhD, Jaroslaw P. Maciejewski, MD PhD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2014) 124 (21): 3205.

https://doi.org/10.1182/blood.V124.21.3205.3205

Published: 2014

Journal Articles

Epigenetic Silencing of BRCA1 Is Linked to Homologous Recombination Repair Defects and Elevated Mir-155 Expression in Myeloid Neoplasms

Weijie Poh, BS, Alison R Moliterno, MD, Keith W. Pratz, MD, Ivana Gojo, MD, Michael A McDevitt, MD PhD, James G. Herman, MD

Blood (2014) 124 (21): 3525.

https://doi.org/10.1182/blood.V124.21.3525.3525

Published: 2014

Journal Articles

Monitoring of Calr Allele Burden in Patients with Essential Thrombocythemia Treated with Imetelstat, a Telomerase Inhibitor, Reveals Rapid and Substantial Molecular Responses

Gabriela M. Baerlocher, MD, Monika Haubitz, PhD, Oliver G. Ottmann, MD, Olatoyosi Odenike, MBBS, Alexander Roeth, MD, Michael A McDevitt, MD PhD, Ted Shih, Bart Burington, Dianne Morfeld, Neeru Batra, BS, David Snyder, MD, Elisabeth Oppliger Leibundgut, PharmD

Blood (2014) 124 (21): 408.

https://doi.org/10.1182/blood.V124.21.408.408

Published: 2014

Journal Articles

Single Cell Analysis Of JAK2 V617F Positive MPN Stem/Progenitor Cells In Chronic Phase and Leukemic Transformation

Jonathan M. Gerber, MD, Donna M. Williams, PhD, Ophelia Rogers, Sarah Morse, Hao Zhang, Michael A McDevitt, MD, PhD, Richard J. Jones, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2013) 122 (21): 1609.

https://doi.org/10.1182/blood.V122.21.1609.1609

Published: 2013

Journal Articles

Polycythemia Vera: Redefinition in the Genomic Era

Alison R. Moliterno, MD, Donna M. Williams, PhD, Michael A McDevitt, MD, PhD, Brady L Stein, MD, Jonathan M. Gerber, MD, Ophelia Rogers, Michael B. Streiff, MD, Sophie Lanzkron, M.D., Linda Resar, M.D., Christine O'Keefe, PhD, Jaroslaw P. Maciejewski, MD, PhD, Jerry L. Spivak, MD

Blood (2012) 120 (21): 1754.

https://doi.org/10.1182/blood.V120.21.1754.1754

Published: 2012

Journal Articles

Somatic Mutations in Schinzel-Giedion Syndrome Gene SETBP1 Determine Progression in Myeloid Malignancies

Blood (2012) 120 (21): 2.

https://doi.org/10.1182/blood.V120.21.2.2

Published: 2012

Journal Articles

Novel Recurrent Mutations in the Ras -Like GTP-Binding Gene Rit1 in Myeloid Malignancies

Inées Góomez-Seguíi, MD., Hideki Makishima, MD, PhD, Andres Jerez, MD, PhD, Kenichi Yoshida, MD, Bartlomiej P Przychodzen, Satoru Miyano, PhD, Yuichi Shiraishi, Holleh D Husseinzadeh, MD, Edward P Evans, Kathryn M Guinta, Naoko Hosono, MD., PhD., Michael A McDevitt, MD, PhD, Alison R. Moliterno, MD, Mikkael A. Sekeres, MD, MS, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2012) 120 (21): 558.

https://doi.org/10.1182/blood.V120.21.558.558

Published: 2012

Journal Articles

Pathway Analysis of Molecular Mutations Can Modify Morphologic, Cytogenetic and Prognostic Risk Stratification Schemes in Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN), and Secondary Acute Myeloid Leukemia (AML)

Edy Hasrouni, Valeria Visconte, PhD, Ali Tabarroki, MD, Heesun J. Rogers, MD, PhD, Fabiola Traina, MD, PhD, Anna Jankowska, MSC, Yang Liu, Betty K. Hamilton, MD, Manoj Bupathi, MD, Hideki Makishima, MD, PhD, Andres Jerez, MD, PhD, Edward A. Copelan, MD, Anjali Advani, MD, Michael A McDevitt, MD, PhD, Matt Kalaycio, MD, Yogen Saunthararajah, MD, Mikkael A. Sekeres, MD, MS, Jaroslaw P. Maciejewski, MD, PhD, Ramon V. Tiu, MD

Blood (2012) 120 (21): 3791.

https://doi.org/10.1182/blood.V120.21.3791.3791

Published: 2012

Journal Articles

Genetic and Epigenetic Defects in DNA Repair Lead to Synthetic Lethality of Poly (ADP-Ribose) Polymerase (PARP) Inhibitors in Aggressive Myeloproliferative Disorders

Michael A McDevitt, MD, PhD, Brian D Koh, Anand Patel, Alison R. Moliterno, MD, Weijie Poh, James G. Herman, MD, Robert L Dilley, B. Douglas Smith, M.D., Judith E. Karp, MD, Jaroslaw P Maciejewski, MD, PhD, Scott H. Kaufmann, MD, PhD, Keith W. Pratz, MD

Blood (2011) 118 (21): 400.

https://doi.org/10.1182/blood.V118.21.400.400

Published: 2011

Journal Articles

Clinical and Genomic Characterization of Chromosome 7 Lesions in Myeloid Malignancies,

Andres Jerez, MD, Yuka Sugimoto, MD, Hideki Makishima, MD, Amit Verma, MD, Christine L O‘Keefe, PhD, Ramon V Tiu, MD, Azim M Mohamedali, PhD, Michael A McDevitt, MD, PhD, Ghulam J. Mufti, MD, Jacqueline Boultwood, PhD, Jaroslaw P Maciejewski, MD, PhD

Blood (2011) 118 (21): 3549.

https://doi.org/10.1182/blood.V118.21.3549.3549

Published: 2011

Journal Articles

Spliceosome GENE MUTATIONS ARE Also PRESENT In the Diverse Mutational Spectrum of CHRONIC Myelomonocytic LEUKEMIA

Hideki Makishima, MD, PhD, Anna M Jankowska, PhD, Valeria Visconte, PhD, Ramon V. Tiu, MD, Kathryn M Guinta, Hadrian Szpurka, PhD, Yuka Sugimoto, MD, PhD, Christine L. O'Keefe, PhD, Alan F. List, MD, Mikkael A Sekeres, MD, Michael A McDevitt, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2011) 118 (21): 1402.

https://doi.org/10.1182/blood.V118.21.1402.1402

Published: 2011

Journal Articles

Defining the Topography of Deletion 5q Using SNP-A Identifies Patients with More Aggressive Disease and Correlates with Additional Lesions

Andres Jerez, MD, Anna M Jankowska, PhD, Hideki Makishima, MD, Lukasz P Gondek, MD, Ramon V Tiu, MD, Christine L O‘Keefe, PhD, Azim M Mohamedali, PhD, Denise Batista, PhD, Michael A McDevitt, MD, PhD, Mikkael A Sekeres, MD, Ghulam J. Mufti, MD, Jaroslaw P Maciejewski, MD, PhD

Blood (2011) 118 (21): 2795.

https://doi.org/10.1182/blood.V118.21.2795.2795

Published: 2011

Journal Articles

Final Results From a Phase II Trial of Triapine® Plus Fludarabine for Adults with Aggressive Myeloproliferative Disorders

Michael A McDevitt, MD, PhD, Robert L Dilley, Keith W. Pratz, MD, B. Douglas Smith, MD, Alison R. Moliterno, MD, Yun Yen, MD, PhD, Lisa Malick, RN, Steven D. Gore, MD, Richard J. Jones, Jaroslaw P. Maciejewski, MD, PhD, Igor Espinoza-Delgado, MD, Judith E. Karp, MD

Blood (2011) 118 (21): 1755.

https://doi.org/10.1182/blood.V118.21.1755.1755

Published: 2011

Journal Articles

Disruption of the ASXL1 Gene Is Prevalent In PMF: Analysis of Molecular Genetics and Clinical Phenotypes

Brady L Stein, MD, Donna M Williams, PhD, Michael A McDevitt, MD, PhD, Christine L. O'Keefe, PhD, Ophelia Rogers, Jerry L Spivak, Jaroslaw Maciejewski, Alison R Moliterno, MD

Blood (2010) 116 (21): 3074.

https://doi.org/10.1182/blood.V116.21.3074.3074

Published: 2010

Journal Articles

Patients with FLT3/ITD AML May Benefit From Allogeneic Transplant In First Remission: Outcomes From a Consecutive Series of Patients at a Single Institution

Amy E. DeZern, MD, Anthony Sung, MD, Sharon Kim, MD, Hua-Ling Tsai, MS, Jeanne Kowalski, PhD, B. Douglas Smith, MD, Judith E. Karp, MD, Steven D. Gore, M.D., Ephraim Fuchs, MD, Michael A McDevitt, MD, PhD, Leo Luznik, MD, Richard J. Jones, MD, Mark J. Levis, MD, PhD

Blood (2010) 116 (21): 2172.

https://doi.org/10.1182/blood.V116.21.2172.2172

Published: 2010

Journal Articles

Next Generation Exome Sequencing for Identification of the Gene Mutations Associated with Loss of Heterozygozity on Chromosome 7 In Myeloid Malignancies

Yuka Sugimoto, MD, PhD, Hideki Makishima, MD, PhD, Hadrian Szpurka, PhD, MSC, Anna Jankowska, MSC, Kathryn Guinta, Ramon V. Tiu, MD, Christine L. O'Keefe, PhD, Alison R Moliterno, MD, Michael A McDevitt, MD, PhD, Hideki Muramatsu, MD., PhD, Seiji Kojima, MD, PhD, Mehdi Keddache, MSC, Jaroslaw Maciejewski

Blood (2010) 116 (21): 297.

https://doi.org/10.1182/blood.V116.21.297.297

Published: 2010

NARROW

Dynamics of Telomere Length Reflect the Clonal Suppression Seen with the Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Leukemias

The JAK2 V617F Stem Cell Burden Is Mosaic, Dynamic and Correlates with Clinical Disease Burden in the MPN: An Exploitable Target

Dynamics of Mutations in Patients with ET Treated with Imetelstat

Essential Thrombocytosis: Redefinition in the Genomic Era

Epigenetic Silencing of BRCA1 Is Linked to Homologous Recombination Repair Defects and Elevated Mir-155 Expression in Myeloid Neoplasms

Monitoring of Calr Allele Burden in Patients with Essential Thrombocythemia Treated with Imetelstat, a Telomerase Inhibitor, Reveals Rapid and Substantial Molecular Responses

Single Cell Analysis Of JAK2 V617F Positive MPN Stem/Progenitor Cells In Chronic Phase and Leukemic Transformation

Polycythemia Vera: Redefinition in the Genomic Era

Somatic Mutations in Schinzel-Giedion Syndrome Gene SETBP1 Determine Progression in Myeloid Malignancies

Novel Recurrent Mutations in the Ras -Like GTP-Binding Gene Rit1 in Myeloid Malignancies

Pathway Analysis of Molecular Mutations Can Modify Morphologic, Cytogenetic and Prognostic Risk Stratification Schemes in Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN), and Secondary Acute Myeloid Leukemia (AML)

Genetic and Epigenetic Defects in DNA Repair Lead to Synthetic Lethality of Poly (ADP-Ribose) Polymerase (PARP) Inhibitors in Aggressive Myeloproliferative Disorders

Clinical and Genomic Characterization of Chromosome 7 Lesions in Myeloid Malignancies,

Spliceosome GENE MUTATIONS ARE Also PRESENT In the Diverse Mutational Spectrum of CHRONIC Myelomonocytic LEUKEMIA

Defining the Topography of Deletion 5q Using SNP-A Identifies Patients with More Aggressive Disease and Correlates with Additional Lesions

Final Results From a Phase II Trial of Triapine® Plus Fludarabine for Adults with Aggressive Myeloproliferative Disorders

Disruption of the ASXL1 Gene Is Prevalent In PMF: Analysis of Molecular Genetics and Clinical Phenotypes

Patients with FLT3/ITD AML May Benefit From Allogeneic Transplant In First Remission: Outcomes From a Consecutive Series of Patients at a Single Institution

Next Generation Exome Sequencing for Identification of the Gene Mutations Associated with Loss of Heterozygozity on Chromosome 7 In Myeloid Malignancies

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