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Journal Articles

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

Sabine Knappe, PhD, Nicolas Fischer, Patrice Robert Douillard, Rudolf Hartmann, PhD, Gerald Schrenk, PhD, Ulla Ravn, Giovanni Magistrelli, Franck Gueneau, Gerard Didelot, Krzysztof Masternak, Marie Kosco-Vilbois, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1083.

https://doi.org/10.1182/blood.V130.Suppl_1.1083.1083

Published: 2017

Journal Articles

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Gerald Schrenk, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1080.

https://doi.org/10.1182/blood.V130.Suppl_1.1080.1080

Published: 2017

Journal Articles

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2017) 130 (Supplement 1): 90.

https://doi.org/10.1182/blood.V130.Suppl_1.90.90

Published: 2017

Journal Articles

Tissue Factor Pathway Inhibitor Isoforms of Macro- and Microvascular Endothelial Cells

Michael Dockal, PhD, Robert Pachlinger, PhD, Angelina Baldin-Stoyanova, Fabian Knofl, Nadja Ullrich, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 4167.

https://doi.org/10.1182/blood.V124.21.4167.4167

Published: 2014

Journal Articles

A TFPI Inhibitory Half Life Extended Fusion Peptide Proves Efficacy in FVIII Knock out Mice and Marmoset Monkeys

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, PhD, Ulrich Reineke, PhD, Alexandra Schiviz, PhD, Werner Hoellriegl, PhD, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1469.

https://doi.org/10.1182/blood.V124.21.1469.1469

Published: 2014

Journal Articles

Recombinant VWF Promotes Platelet Adhesion Under Shear Stress Dependent on Its Multimer Size

Gerald Schrenk, PhD, Jutta Schreiner, Herbert Gritsch, Peter L Turecek, PhD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1442.

https://doi.org/10.1182/blood.V124.21.1442.1442

Published: 2014

Journal Articles

Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Christoph Redl, Erwin Panholzer, Willibald Kammlander, Frank Osterkamp, PhD, Ulrich Reineke, PhD, Hans Brandstetter, Prof., Friedrich Scheiflinger, PhD

Blood (2014) 124 (21): 1484.

https://doi.org/10.1182/blood.V124.21.1484.1484

Published: 2014

Journal Articles

Concomitant Administration Of Activated Prothrombin Complex Concentrate and Recombinant Activated Factor VII At Low Doses Are Efficacious and Safe In Hemophilic Mice

Michael Dockal, PhD, Sabine Knappe, PhD, Peter Leidenmuehler, Christina Piskernik, DVM, Sylvia Tippl, Marlene Resch, DVM, Dagmar Verdino, DVM, Alexander Bauer, Werner Hoellriegl, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 2353.

https://doi.org/10.1182/blood.V122.21.2353.2353

Published: 2013

Journal Articles

TFPI Expresses Anticoagulant Activity Independent Of TF-FVIIa

Stella Thomassen, PhD, Alexandra Heinzmann, PhD, Linda Herfs, Jan Rosing, PhD, Tilman M. Hackeng, PhD, Rudolf Hartmann, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2013) 122 (21): 3563.

https://doi.org/10.1182/blood.V122.21.3563.3563

Published: 2013

Journal Articles

Design Of a Most Efficient Inhibitor Of TFPI By Molecular Fusion Of Two Inhibitory Peptides

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, PhD, Johannes Brandstetter, PhD, Willibald Kammlander, Erwin Panholzer, Christoph Redl, Frank Osterkamp, PhD, Jan Rosing, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 3564.

https://doi.org/10.1182/blood.V122.21.3564.3564

Published: 2013

Journal Articles

Binding Of Recombinant Activated Factor VII (rFVIIa) To Human Platelets Identifies Donor Variation and Platelet Subpopulations With Increased Binding Of rFVIIa In Platelet Concentrates From Healthy Donors

Jadranka Koehn, PhD, Ernst Boehm, PhD, Michael Dockal, PhD, Andrea Sedivy, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 3565.

https://doi.org/10.1182/blood.V122.21.3565.3565

Published: 2013

Journal Articles

Crystal Structure Of Tissue Factor Pathway Inhibitor (TFPI) Kunitz Domain 1 and 2 In Complex With An Inhibitory Cyclic Peptide,

Michael Dockal, PhD, Rudolf Hartmann, PhD, Markus Fries, PhD, Katerina Prohaska, Robert Pachlinger, PhD, Thomas Polakowski, PhD, Johannes Brandstetter, PhD, Jan Rosing, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 453.

https://doi.org/10.1182/blood.V122.21.453.453

Published: 2013

Journal Articles

Biological Explanation of Clinically Observed Elevation of TFPI Plasma Levels After Treatment with TFPI-Antagonistic Aptamer BAX 499

Michael Dockal, PhD, Robert Pachlinger, Rudolf Hartmann, PhD, Sabine Knappe, PhD, Benny Sorensen, Wing Yen Wong, Maureen Conlan, Michael Cecerle, Bruce M. Ewenstein, MD PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 1104.

https://doi.org/10.1182/blood.V120.21.1104.1104

Published: 2012

Journal Articles

Structure-Activity Relationship of Pro- and Anticoagulant Effects of Fucus Vesiculosus Fucoidan

Michael Dockal, PhD, Susanne Till, PhD, Zhenqing Zhang, Sabine Knappe, PhD, Sabrina Reutterer, Catherine Quinn, Christoph Redl, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Christina Szabo

Blood (2012) 120 (21): 3353.

https://doi.org/10.1182/blood.V120.21.3353.3353

Published: 2012

Journal Articles

Effect of Increased Tissue Factor Pathway Inhibitor (TFPI) Levels On Factor Xa Inhibition and Global Hemostasis in the Presence of TFPI-Antagonistic Aptamer BAX 499.

Michael Dockal, PhD, Rudolf Hartmann, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Willibald Kammlander, PhD, Klara Kunckova, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 2207.

https://doi.org/10.1182/blood.V120.21.2207.2207

Published: 2012

Journal Articles

Glycosylphosphatidylinositol Anchored TFPI As Main Regulator of Factor X Activation On the Surface of Endothelial Cells.

Michael Dockal, PhD, Robert Pachlinger, Angelina Baldin-Stoyanova, Fabian Knofl, Nadja Ullrich, Jadranka Koehn, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 2210.

https://doi.org/10.1182/blood.V120.21.2210.2210

Published: 2012

Journal Articles

Structural and Functional Characterization of Fucoidan and Its Procoagulant Effect in An Ex Vivo Model of Factor VIII-Inhibited Guinea Pigs

Michael Dockal, PhD, Werner Hoellriegl, Zhenqing Zhang, Susanne Till, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Alexandra Schiviz, Hartmut J. Ehrlich, MD, Christina Szabo, Eva-Maria Muchitsch, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 2262.

https://doi.org/10.1182/blood.V118.21.2262.2262

Published: 2011

Journal Articles

Peptides Inhibiting Tissue Factor Pathway Inhibitor Improve Hemostasis in Mice

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, MBA, Osterkamp Frank, Hartmut J. Ehrlich, MD, Alexandra Schiviz, Werner Hoellriegl, Eva-Maria Muchitsch, Ulrich Reinecke, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 24.

https://doi.org/10.1182/blood.V118.21.24.24

Published: 2011

Journal Articles

Peptides Binding to Kunitz Domain 1 of Tissue Factor Pathway Inhibitor (TFPI) Inhibit All Functions of TFPI and Improve Thrombin Generation of Hemophilia Plasma

Michael Dockal, PhD, Johannes Brandstetter, PhD, Martin Ludwiczek, Georg Kontaxis, PhD, Markus Fries, PhD, M C L G D Thomassen, PhD, A Heinzmann, PhD, Hartmut J. Ehrlich, MD, Katerina Prohaska, Rudolf Hartmann, PhD, Jan Rosing, Professor, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 2245.

https://doi.org/10.1182/blood.V118.21.2245.2245

Published: 2011

Journal Articles

Strong Correlation of High Endogenous Plasma Levels of Tissue Factor Pathway Inhibitor (TFPI) with Poor Blood Clotting and Corrective Action of BAX 513 Under FVIII-Inhibited Conditions

Michael Dockal, PhD, Monika Gorczyca, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Bernd Jilma, MD

Blood (2011) 118 (21): 1201.

https://doi.org/10.1182/blood.V118.21.1201.1201

Published: 2011

NARROW

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

Tissue Factor Pathway Inhibitor Isoforms of Macro- and Microvascular Endothelial Cells

A TFPI Inhibitory Half Life Extended Fusion Peptide Proves Efficacy in FVIII Knock out Mice and Marmoset Monkeys

Recombinant VWF Promotes Platelet Adhesion Under Shear Stress Dependent on Its Multimer Size

Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides

Concomitant Administration Of Activated Prothrombin Complex Concentrate and Recombinant Activated Factor VII At Low Doses Are Efficacious and Safe In Hemophilic Mice

TFPI Expresses Anticoagulant Activity Independent Of TF-FVIIa

Design Of a Most Efficient Inhibitor Of TFPI By Molecular Fusion Of Two Inhibitory Peptides

Binding Of Recombinant Activated Factor VII (rFVIIa) To Human Platelets Identifies Donor Variation and Platelet Subpopulations With Increased Binding Of rFVIIa In Platelet Concentrates From Healthy Donors

Crystal Structure Of Tissue Factor Pathway Inhibitor (TFPI) Kunitz Domain 1 and 2 In Complex With An Inhibitory Cyclic Peptide,

Biological Explanation of Clinically Observed Elevation of TFPI Plasma Levels After Treatment with TFPI-Antagonistic Aptamer BAX 499

Structure-Activity Relationship of Pro- and Anticoagulant Effects of Fucus Vesiculosus Fucoidan

Effect of Increased Tissue Factor Pathway Inhibitor (TFPI) Levels On Factor Xa Inhibition and Global Hemostasis in the Presence of TFPI-Antagonistic Aptamer BAX 499.

Glycosylphosphatidylinositol Anchored TFPI As Main Regulator of Factor X Activation On the Surface of Endothelial Cells.

Structural and Functional Characterization of Fucoidan and Its Procoagulant Effect in An Ex Vivo Model of Factor VIII-Inhibited Guinea Pigs

Peptides Inhibiting Tissue Factor Pathway Inhibitor Improve Hemostasis in Mice

Peptides Binding to Kunitz Domain 1 of Tissue Factor Pathway Inhibitor (TFPI) Inhibit All Functions of TFPI and Improve Thrombin Generation of Hemophilia Plasma

Strong Correlation of High Endogenous Plasma Levels of Tissue Factor Pathway Inhibitor (TFPI) with Poor Blood Clotting and Corrective Action of BAX 513 Under FVIII-Inhibited Conditions

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American Society of Hematology

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ASH Publications

American Society of Hematology

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