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Journal Articles

The Common PAR4 Ala120Thr Variant Has a Major Effect on Platelet Reactivity to Thrombin and These Effects Are Enhanced with PAR1 and P2Y12 Inhibition

Michael J. Whitley, Joanne Vesci, Michael Holinstat, PhD, Leonard C. Edelstein, PhD, Paul F. Bray, MD

Blood (2016) 128 (22): 709.

https://doi.org/10.1182/blood.V128.22.709.709

Published: 2016

Journal Articles

Potent Anti-Platelet Metabolite, 12-HETrE, Inhibits Platelet Activation and Thrombosis In Vivo Via Activation of the IP Receptor

Benjamin Tourdot, PhD, Zitha Isingizwe, BS, Jennifer Yeung, Reheman Adili, MD, Michael Holinstat, PhD

Blood (2016) 128 (22): 714.

https://doi.org/10.1182/blood.V128.22.714.714

Published: 2016

Journal Articles

Novel 12-LOX Inhibitor ML355 Attenuates Platelet Reactivity and Impairs Thrombus Growth, Stability and Vessel Occlusion In Vivo

Reheman Adili, MD, Theodore R Holman, PhD, Michael Holinstat, PhD

Blood (2015) 126 (23): 3442.

https://doi.org/10.1182/blood.V126.23.3442.3442

Published: 2015

Journal Articles

Pharmacogenocis of PAR4: PAR4 Polymorphism Determines Platelet Response in the Presence of Dual Anti-Platelet Therapy

Benjamin Tourdot, PhD, Paul F. Bray, MD, Leonard C. Edelstein, PhD, Michael Holinstat, PhD FAHA

Blood (2015) 126 (23): 3446.

https://doi.org/10.1182/blood.V126.23.3446.3446

Published: 2015

Journal Articles

Identification of the Genetic Mechanism Responsible for Racially-Dimorphic Expression of the Thrombin-Receptor Regulator, Pctp

Xiango Kong, MD, Lukas Simon, B.A, Katrina Leung, Michael Holinstat, PhD, Chad Shaw, PhD, Paul F. Bray, MD, Leonard C. Edelstein, PhD

Blood (2015) 126 (23): 415.

https://doi.org/10.1182/blood.V126.23.415.415

Published: 2015

Journal Articles

Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

Leonard C. Edelstein, PhD, Lukas M Simon, Cory R Lindsay, PhD, Xiango Kong, MD, Raul Teruel Montoya, PhD, Benjamin E Tourdot, PhD, Edward Chen, PhD, Lin Ma, Shaun R Coughlin, PhD, Marvin T. Nieman, PhD, Michael Holinstat, PhD, Chad Shaw, PhD, Paul F Bray, MD

Blood (2014) 124 (21): 1434.

https://doi.org/10.1182/blood.V124.21.1434.1434

Published: 2014

Journal Articles

12-HETrE, a Novel 12-LOX Oxylipin, Prevents Platelet Activation in a Gα s -like Manner

Jennifer Yeung, MS, Pilar Fernandez-Perez, BS, Joanne Vesci, MLT, Theodore R Holman, PhD, Jin Ren, PhD, Michael Holinstat, PhD

Blood (2014) 124 (21): 1436.

https://doi.org/10.1182/blood.V124.21.1436.1436

Published: 2014

Journal Articles

Effect Of Age and Gender On Human Platelet mRNA and Micro-RNA Levels

Lukas M Simon, Leonard C. Edelstein, PhD, Srikanth Nagalla, MD, MS, Angela Bergeron, Edward Chen, PhD, Xianguo Kong, MD, Lin Ma, Satya P. Kunapuli, PhD, Michael Holinstat, PhD, Steven E. McKenzie, MD, PhD, Jing-fei Dong, MD, PhD, Chad Shaw, PhD, Paul F Bray, MD

Blood (2013) 122 (21): 3518.

https://doi.org/10.1182/blood.V122.21.3518.3518

Published: 2013

Journal Articles

12-Lipoxygenase Regulates Platelet Reactivity and Thrombosis Through Formation Of Unique Oxylipins

Jennifer Yeung, MS, Pilar Fernandez-Perez, MS, Joanne Vesci, MLT, Theodore R Holman, PhD, Michael Holinstat, PhD

Blood (2013) 122 (21): 3515.

https://doi.org/10.1182/blood.V122.21.3515.3515

Published: 2013

Journal Articles

Racial Differences In Thrombin-Induced Human Platelet PAR4 Reactivity

Leonard C. Edelstein, PhD, Lukas M Simon, Raul Teruel Montoya, Ph.D., Michael Holinstat, PhD, Edward Chen, PhD, Angela Bergeron Woodley, BS, Xiango Kong, MD, Srikanth Nagalla, MD, MS, Narla Mohandas, D.Sc., David Cohen, MD, PhD, Jing-fei Dong, MD, PhD, Chad A Shaw, PhD, Paul F Bray, MD

Blood (2013) 122 (21): 1054.

https://doi.org/10.1182/blood.V122.21.1054.1054

Published: 2013

Journal Articles

An ω-6 Fatty Acid, Dgla, Prevents Platelet Activation and Thrombosis in Vivo .

Jennifer Yeung, Kenneth Ikei, Joanne Vesci, MLT, Theodore R Holman, PhD, Michael Holinstat, PhD

Blood (2012) 120 (21): 2169.

https://doi.org/10.1182/blood.V120.21.2169.2169

Published: 2012

Journal Articles

A Large Cluster of Micrornas At 14q32 Defines an RNA Expression Module That Accounts for Racial Differences in Protease Activated Receptor 4-Mediated Platelet Reactivity

Leonard C. Edelstein, PhD, Lukas M. Simon, Edward Chen, PhD, Angela Bergeron, Xiango Kong, MD, Lin Ma, Raul Teruel-Montoya, PhD, Michael Holinstat, PhD, Srikanth Nagalla, MD, MS, Jing-fei Dong, MD, PhD, Chad Shaw, PhD, Paul F. Bray, MD

Blood (2012) 120 (21): 380.

https://doi.org/10.1182/blood.V120.21.380.380

Published: 2012

Journal Articles

12-HETrE, An Endogenous Inhibitor of Platelet Activation,

Jennifer Yeung, Kenneth Ikei, Joanne Vesci, MLT, Alex Arnouk, Theodore R Holman, PhD, Michael Holinstat, PhD

Blood (2011) 118 (21): 3254.

https://doi.org/10.1182/blood.V118.21.3254.3254

Published: 2011

Journal Articles

Platelet 12-Lipoxygenase Is Required for Dense Granule Secretion and Platelet Aggregation: Role of 12-hLO In Platelet Hemostasis and Thrombosis

Patrick Apopa, PhD, Megha Patel, B.S., Olivier Boutaud, PhD, Michael Holinstat, PhD

Blood (2010) 116 (21): 3203.

https://doi.org/10.1182/blood.V116.21.3203.3203

Published: 2010

Journal Articles

Irreversible Platelet Activation Requires PAR1 Regulation of Phosphatidylinositol Phosphates (PIP n s) Activation of Rap1.

Michael Holinstat, PhD, W. James Hudson, M.S., Anita M. Preininger, Ph.D., Heidi E. Hamm, Ph.D.

Blood (2007) 110 (11): 3889.

https://doi.org/10.1182/blood.V110.11.3889.3889

Published: 2007

Journal Articles

Protease Activated Receptors Differentially Regulate Human Platelet Activation through Phosphatidic Acid-Dependent DAG Formation.

Michael Holinstat, PhD, Heidi E. Hamm, PhD

Blood (2006) 108 (11): 3906.

https://doi.org/10.1182/blood.V108.11.3906.3906

Published: 2006

NARROW

The Common PAR4 Ala120Thr Variant Has a Major Effect on Platelet Reactivity to Thrombin and These Effects Are Enhanced with PAR1 and P2Y12 Inhibition

Potent Anti-Platelet Metabolite, 12-HETrE, Inhibits Platelet Activation and Thrombosis In Vivo Via Activation of the IP Receptor

Novel 12-LOX Inhibitor ML355 Attenuates Platelet Reactivity and Impairs Thrombus Growth, Stability and Vessel Occlusion In Vivo

Pharmacogenocis of PAR4: PAR4 Polymorphism Determines Platelet Response in the Presence of Dual Anti-Platelet Therapy

Identification of the Genetic Mechanism Responsible for Racially-Dimorphic Expression of the Thrombin-Receptor Regulator, Pctp

Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

12-HETrE, a Novel 12-LOX Oxylipin, Prevents Platelet Activation in a Gα s -like Manner

Effect Of Age and Gender On Human Platelet mRNA and Micro-RNA Levels

12-Lipoxygenase Regulates Platelet Reactivity and Thrombosis Through Formation Of Unique Oxylipins

Racial Differences In Thrombin-Induced Human Platelet PAR4 Reactivity

An ω-6 Fatty Acid, Dgla, Prevents Platelet Activation and Thrombosis in Vivo .

A Large Cluster of Micrornas At 14q32 Defines an RNA Expression Module That Accounts for Racial Differences in Protease Activated Receptor 4-Mediated Platelet Reactivity

12-HETrE, An Endogenous Inhibitor of Platelet Activation,

Platelet 12-Lipoxygenase Is Required for Dense Granule Secretion and Platelet Aggregation: Role of 12-hLO In Platelet Hemostasis and Thrombosis

Irreversible Platelet Activation Requires PAR1 Regulation of Phosphatidylinositol Phosphates (PIP n s) Activation of Rap1.

Protease Activated Receptors Differentially Regulate Human Platelet Activation through Phosphatidic Acid-Dependent DAG Formation.

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American Society of Hematology

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American Society of Hematology

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