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Michael Palladino
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Journal Articles

Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells

Claudia P. Miller, Sharmistha Rudra, Michael J. Keating, William G. Wierda, Michael Palladino, Joya Chandra
Journal: Blood
Blood (2009) 113 (18): 4289–4299.
https://doi.org/10.1182/blood-2008-08-174797
Published: 2009
Journal Articles

Combination of Proteasome Inhibitors Bortezomib and NPI-0052 Trigger In Vivo Synergistic Cytotoxicity in Multiple Myeloma.

Dharminder Chauhan, PhD, Ajita Singh, Ph.D, Mohan Brahmandam, M.S, Klaus Podar, Ph.D, Teru Hideshima, M.D., Robert Schlossman, M.D., Paul Richardson, M.D., Nikhil Munshi, M.D., Michael Palladino, Ph.D, Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2007) 110 (11): 2524.
https://doi.org/10.1182/blood.V110.11.2524.2524
Published: 2007
Journal Articles

The Combination of Bortezomib and NPI-0052 Exerts Anti-Tumor Activity in Waldenstrom Macroglobulinemia (WM).

Aldo Roccaro, MD, Xavier Leleu, MD, Antonio Sacco, Xiaoying Jia, Anne-Sophie Moreau, MD, Hai Ngo, Abdelkareem Azab, Feda Azab, Evdoxia Hatjiharissi, MD, Steven Treon, MD, Teru Hideshima, MD, Michael Palladino, Kenneth Anderson, MD, Dharminder Chuahan, Irene Ghobrial, MD
Journal: Blood
Blood (2007) 110 (11): 1516.
https://doi.org/10.1182/blood.V110.11.1516.1516
Published: 2007
Journal Articles

Targeting Cdk4/6 in Combination Therapy Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma through Synergistic Mitochondria Depolarization.

Xiangao Huang, PhD, Tracey Louie, B.Sc., Maurizio Di Liberto, Ph.D., Jun Rice, Ph.D., David Jayabalan, B.Sc., Kang Zhang, B.Sc., Michael Palladino, Ph.D., Isan Chen, M.D., Peter Toogood, Ph.D, Ruben Niesvizky, M.D., Malcolm A.S. Moore, Ph.D., Selina Chen-Kiang, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 667.
https://doi.org/10.1182/blood.V110.11.667.667
Published: 2007
Journal Articles

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

Claudia P. Miller, Kechen Ban, Melanie E. Dujka, David J. McConkey, Mark Munsell, Michael Palladino, Joya Chandra
Journal: Blood
Blood (2007) 110 (1): 267–277.
https://doi.org/10.1182/blood-2006-03-013128
Published: 2007
Journal Articles

The Proteasome Inhibitor NPI-0052 in Combination with Bortezomib Induces Antitumor Activity in Waldenstrom Macroglobulinemia.

Xiaoying Jia, Xavier Leleu, MD, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Hai Ngo, Garrett O’Sullivan, Douglas McMillin, PhD, Steven Treon, MD, Constantine Mitsiades, MD, Teru Hideshima, MD, Michael Palladino, Kenneth Anderson, MD, Dharminder Chauhan, PhD, Irene Ghobrial, MD
Journal: Blood
Blood (2006) 108 (11): 4746.
https://doi.org/10.1182/blood.V108.11.4746.4746
Published: 2006
Journal Articles

Induction of RKIP and Inhibition of the Transcription Repressor YY1 in B-NHL by the Novel Proteasome Inhibitor NPI-0052 and Sensitization to TRAIL-Induced Apoptosis.

Eriko Suzuki, Sara Huerta-Yepez, Ph.D., Stavroula Baritaki, Ph.D., Michael Palladino, Ph.D., Benjamin Bonavida, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 2391.
https://doi.org/10.1182/blood.V108.11.2391.2391
Published: 2006
Journal Articles

The Novel, Orally Active Proteasome Inhibitor, NPI-0052, Induces Apoptosis in Leukemia Lymphoma Cell Lines and Patient Specimens.

Claudia P. Miller, MS, Kechen Ban, PhD, Stacey L. Ruiz, Saskia Neuteboom, PhD, Michael Palladino, PhD, David McConkey, PhD, Joya Chandra, PhD
Journal: Blood
Blood (2005) 106 (11): 241.
https://doi.org/10.1182/blood.V106.11.241.241
Published: 2005
Journal Articles

In Vitro and In Vivo Proteasome Activity Profiles of Bortezomib and a Novel Proteasome Inhibitor NPI-0052.

Dharminder Chauhan, PhD, Ta-Hsiang Chao, Ph.D, Laurence Catley, M.D, Benjamin Nicholson, Ph.D, Mugdha Velanker, M.S, Teru Hideshima, Ph.D, Celia Berkers, Ph.D, Huib Ovaa, Ph.D, Saskia Neuteboom, Ph.D, Michael Palladino, Ph.D, Kenneth C. Anderson, M.D
Journal: Blood
Blood (2005) 106 (11): 3363.
https://doi.org/10.1182/blood.V106.11.3363.3363
Published: 2005
Journal Articles

Chemosensitization of Drug and Rituximab-Resistant Daudi B-NHL Clones to Drug-Induced Apoptosis by the Proteasome Inhibitor NPI-0052.

Eriko Suzuki, Ali Jazirehi, PhD, Michael Palladino, PhD, Benjamin Bonavida, PhD
Journal: Blood
Blood (2005) 106 (11): 1521.
https://doi.org/10.1182/blood.V106.11.1521.1521
Published: 2005
Journal Articles

A Novel Orally Available Proteasome Inhibitor NPI-0052 Induces Killing in Multiple Myeloma (MM) Cells Resistant to Conventional and Bortezomib Therapies.

Dharminder Chauhan, Ph.D, Guilan Li, M.S, Klaus Podar, Ph.D, Teru Hideshima, Ph.D, Reshma Shrigarpure, Ph.D, Laurence Catley, M.D, Constantine Mitsiades, Ph.D, Nikhil Munshi, M.D, Robert Sclossman, M.D, Rena Bahjat, Ph.D, Saskia Neuteboom, M.D., Paul Richardson, M.D, Michael Palladino, Ph.D, Kenneth C. Anderson, M.D
Journal: Blood
Blood (2004) 104 (11): 2405.
https://doi.org/10.1182/blood.V104.11.2405.2405
Published: 2004