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Michael W. Ruff, MD
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Journal Articles

Axl-RTK Inhibition Modulates Monocyte Immune Response to Enhance the Anti-Tumor Effects of CD19 Redirected Chimeric Antigen Receptor T Cells in Preclinical Models

Reona Sakemura, MDPhD, Michelle J. Cox, Elizabeth L. Siegler, PhD, Erin E. Tapper, Wendy K. Nevala, Mehrdad Hefazi, MD, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Evandro D. Bezerra, MD, Lionel Kankeu Fonkoua, MD, Paulina Horvei, MD, Michael W. Ruff, MD, Lars Mouritsen, Jason M. Foulks, PhD, Steven L. Warner, PhD, Wei Ding, MD PhD, Susan L. Slager, PhD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MB, ChB
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-142159
Published: 2020
Journal Articles

Vesicular Stomatitis Virus (VSV) Engineered to Express CD19 Stimulates Anti-CD19 Chimeric Antigen Receptor Modified T Cells and Promotes Their Anti-Tumor Effects

Reona Sakemura, MDPhD, Elizabeth C. Eckert, PhD, Sydney B. Crotts, Linh Pham, Elizabeth L. Siegler, PhD, Michelle J. Cox, Erin E. Tapper, Mehrdad Hefazi, MD, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Evandro D. Bezerra, MD, Lionel Kankeu Fonkoua, MD, Paulina Horvei, MD, Michael W. Ruff, MD, Susan L. Slager, PhD, Sameer A. Parikh, MD, Neil E. Kay, MD, Kah-Whye Peng, PhD, Stephen J. Russell, MD PhD, Saad S. Kenderian, MB, ChB
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-139647
Published: 2020
Journal Articles

Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy

Elizabeth L. Siegler, PhD, Brandon W Simone, Reona Sakemura, MDPhD, Erin E. Tapper, Paulina Horvei, MD, Michelle J. Cox, Mehrdad Hefazi, MD, Claudia Manriquez Roman, Ismail Can, Kendall J. Schick, Michael W. Ruff, MD, Stephen C Ekker, PhD, Saad S. Kenderian, MB, ChB
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-141115
Published: 2020
Journal Articles

Targeting of CD19 By Tafasitamab Does Not Impair CD19 Directed Chimeric Antigen Receptor T Cell Activity in Vitro

Paulina Horvei, MD, Reona Sakemura, MD PhD, Michelle J. Cox, Michael W. Ruff, MD, Mehrdad Hefazi, MD, Erin E. Tapper, Kendall J. Schick, Claudia Manriquez Roman, Charles J. Kuhlmann, Juergen Schanzer, Jan Endell, Grzegorz Nowakowski, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2859.
https://doi.org/10.1182/blood-2019-130506
Published: 2019
Journal Articles

Circulating Extracellular Vesicles Induce Chimeric Antigen Receptor T Cell Dysfunction in Chronic Lymphocytic Leukemia (CLL)

Michelle J. Cox, Fabrice Lucien-Matteoni, PhD, Reona Sakemura, MD PhD, Justin C. Boysen, Yohan Kim, MS, Michael J. Hansen, Claudia Manriquez Roman, Erin E. Tapper, Sydney B. Crotts, Kendall J. Schick, Mehrdad Hefazi, MD, Paulina Roman Moreno, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 679.
https://doi.org/10.1182/blood-2019-125272
Published: 2019
Journal Articles

Targeting Cancer Associated Fibroblasts in the Bone Marrow Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma

Reona Sakemura, MD PhD, Michelle J. Cox, Michael J. Hansen, Mehrdad Hefazi, MD, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Roman Moreno, MD, Michael W. Ruff, MD, Denise K Walters, PhD BSc, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 865.
https://doi.org/10.1182/blood-2019-123277
Published: 2019
Journal Articles

Development of a Sensitive and Efficient Reporter Platform for the Detection of Chimeric Antigen Receptor T Cell Expansion, Trafficking, and Toxicity

Reona Sakemura, MD PhD, Lukkana Suksanpaisan, PhD, Roman H Khadka, Alysha N Newsom, Michael J. Hansen, Michelle J. Cox, Mehrdad Hefazi, MD, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Roman Moreno, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Kah-Whye Peng, PhD, Stephen J Russell, MD PhD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 53.
https://doi.org/10.1182/blood-2019-123476
Published: 2019
Journal Articles

Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

Michelle J. Cox, Charles J. Kuhlmann, Rosalie M. Sterner, Reona Sakemura, MD PhD, Sutapa Sinha, PhD, Raphael Mwangi, MS, Nancy Scott, MS, Mehrdad Hefazi, MD, Omar Ahmed, Dale Chappell, Cameron Durrant, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Horvei, MD, Michael W. Ruff, MD, Sameer A. Parikh, MD, Neil E. Kay, MD, Saad S. Kenderian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3868.
https://doi.org/10.1182/blood-2019-129349
Published: 2019