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Journal Articles

Attempts to Induce t(11;14) during Redifferentiation of Normal B Cell-Derived Ips Cells to Study Myeloma-Initiating Cells

Naohiro Tsuyama, Misaki Takahashi Sugai, Ken-ichi Kudo, Yusuke Azami, Megumi Sasatani, Kenji Kamiya, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai

Blood (2022) 140 (Supplement 1): 12471–12472.

https://doi.org/10.1182/blood-2022-158655

Published: 2022

Journal Articles

Normal B Cell-Derived iPSCs Capable of Inducing RAS Mutants and Aid to Explore Myeloma-Initiating Cells

Ken-ichi Kudo, Naohiro Tsuyama, Misaki Takahashi Sugai, Yusuke Azami, Miwa Fukami, Yu Abe, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai

Blood (2021) 138 (Supplement 1): 4711.

https://doi.org/10.1182/blood-2021-149108

Published: 2021

Journal Articles

Chromosomal Translocation t(11;14) Induced By the Cre-Loxp System in Normal B Cell-Derived Ips Cells for the Study of Myeloma-Initiating Cells

Misaki Sugai, BS, Naohiro Tsuyama, PhD, Yu Abe, PhD, Yusuke Azami, MD, Kenichi Kudo, PhD, Akinobu Ota, PhD, Sivasundaram Karnan, PhD, Moe Muramatsu, BS, Tomonari Shigemura, MD PhD, Megumi Sasatani, PhD, Yuko Hashimoto, MD PhD, Kenji Kamiya, MD PhD, Ichiro Hanamura, MD PhD, Takayuki Ikezoe, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MD PhD

Blood (2020) 136 (Supplement 1): 18–19.

https://doi.org/10.1182/blood-2020-134572

Published: 2020

Journal Articles

Introduction of Chromosomal Translocation t(11; 14) and a p53 Deletion into Normal B Cell-Derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells

Aki Yanagi, MS, Naohiro Tsuyama, PhD, Misaki Sugai, BS, Yu Abe, PhD, Yusuke Azami, MD, Yukari Yanai, MS, Akinobu Ota, PhD, Karnan Sivasundaram, PhD, Moe Muramatsu, BS, Tomonari Shigemura, MD PhD, Megumi Sasatani, PhD, Yuko Hashimoto, MD PhD, Kenji Kamiya, MD PhD, Ichiro Hanamura, MD PhD, Takayuki Ikezoe, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MD PhD

Blood (2019) 134 (Supplement_1): 3057.

https://doi.org/10.1182/blood-2019-122344

Published: 2019

Journal Articles

Attempt to Prove the Existence of Abnormal B Lymphocyte As Myeloma-Initiating Cells from B Cell-Derived Induced Pluripotent Stem Cells

Aki Yanagi, MS, Naohiro Tsuyama, PhD, Yukari Yanai, MS, Yu Abe, PhD, Misaki Sugai, BS, Akinobu Ota, PhD, Karnan Sivasundaram, PhD, Tomonari Shigemura, MD PhD, Megumi Sasatani, PhD, Kenji Kamiya, MD PhD, Ichiro Hanamura, MD PhD, Takayuki Ikezoe, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MD PhD

Blood (2018) 132 (Supplement 1): 1896.

https://doi.org/10.1182/blood-2018-99-112759

Published: 2018

Journal Articles

B Cell-Derived Induced Pluripotent Stem Cells Are Useful for Determining the Cellular Origin of Abnormal B Cells in Multiple Myeloma

Aki Yanagi, Fumihiko Kawamura, MS, Makoto Inaki, PhD, Atsushi Katafuchi, PhD, Yukari Yanai, MS, Yu Abe, MD, Naohiro Tsuyama, PhD, Misaki Sugai, BS, Mitsunori Higuchi, MD PhD, Satoshi Muto, MD PhD, Takumi Yamaura, MD, Hiroyuki Suzuki, MD PhD, Hideyoshi Noji, MD PhD, Shinichi Suzuki, MD PhD, Yoshida A Mitsuaki, PhD, Megumi Sasatani, PhD, Kenji Kamiya, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MDPhD

Blood (2017) 130 (Supplement 1): 1808.

https://doi.org/10.1182/blood.V130.Suppl_1.1808.1808

Published: 2017

Journal Articles

Establishment of Induced Pluripotent Stem Cells from Lymph Node B Cells and Induction of Aid Expression in Their Differentiation into Hematopoietic Stem Cells

Fumihiko Kawamura, MS, Inaki Makoto, PhD, Atsushi Katafuchi, PhD, Yu Abe, MS, Naohiro Tsuyama, PhD, Yumiko Kurosu, BS, Aki Yanagi, MS, Mitsunori Higuchi, MD PhD, Satoshi Muto, MD PhD, Takumi Yamamura, MD, Hiroyuki Suzuki, MD PhD, Hideyoshi Noji, MD PhD, Shinichi Suzuki, MD PhD, Mitsuaki A Yoshida, PhD, Megumi Sasatani, PhD, Kenji Kamiya, MD PhD, Masafumi Onodera, MD PhD, Akira Sakai, MD PhD

Blood (2016) 128 (22): 5049.

https://doi.org/10.1182/blood.V128.22.5049.5049

Published: 2016

Journal Articles

Cyclin D1 Overexpression Increases Chemosensitivity Via Prolonged S-Phase and TRAIL Signal in Myeloma Cell.

Yoshiaki Kuroda, MD, Akira Sakai, M.D., Naohiro Tsuyama, Ph.D., Yuta Katayama, M.D., Shoso Munemasa, M.D., Yoshiko Okikawa, M.D., Hideki Asaoku, M.D., Nanae Nakaju, Mami Mizuno, Takashi Nishizaka, M.D., Katsunari Ogawa, Hideo Tanaka, M.D., Akiro Kimura, M.D.

Blood (2007) 110 (11): 3530.

https://doi.org/10.1182/blood.V110.11.3530.3530

Published: 2007

Journal Articles

Cyclin D1 Overexpression Increases Chemosensitivity Via the Induction of Bim in Myeloma Cells.

Yoshiaki Kuroda, MD, Akira Sakai, M.D., Naohiro Tsuyama, Ph.D., Shoso Munemasa, M.D., Nanae Nakaju, Mami Mizuno, Yoshiko Okikawa, M.D., Yuta Katayama, M.D., Akiro Kimura, M.D.

Blood (2006) 108 (11): 3418.

https://doi.org/10.1182/blood.V108.11.3418.3418

Published: 2006

Journal Articles

Induction of Cyclin D1 Gene in Myeloma Cells Down-Regulates the Expression of Cyclin D2.

Yoshiaki Kuroda, MD, Akira Sakai, MD, Naohiro Tsuyama, PhD, Mami Mizuno, Nanae Nakaju, Shoso Munemasa, MD, Yoshiko Okikawa, MD, Yuta Katayama, MD, Akiro Kimura, MD

Blood (2005) 106 (11): 3411.

https://doi.org/10.1182/blood.V106.11.3411.3411

Published: 2005

Journal Articles

Galectin-1 Can Support the Survival of Human Myeloma Cells in In Vitro Culture.

Saeid Abroun, MD, Fu-Jun Li, MD, Naohiro Tsuyama, Karim Shamsasenjan, Hideki Asaoku, Toshikazu Gondo, MD, Michio M. Kawano, MD

Blood (2005) 106 (11): 2499.

https://doi.org/10.1182/blood.V106.11.2499.2499

Published: 2005

Journal Articles

A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma

Fu-Jun Li, Naohiro Tsuyama, Hideaki Ishikawa, Masanori Obata, Saeid Abroun, Shangqin Liu, Ken-ichiro Otsuyama, Xu Zheng, Zi Ma, Yasuko Maki, Michio M. Kawano

Blood (2005) 105 (8): 3295–3302.

https://doi.org/10.1182/blood-2004-10-4083

Published: 2005

Journal Articles

Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells

Zi Ma, Ken-ichiro Otsuyama, Shangqin Liu, Saeid Abroun, Hideaki Ishikawa, Naohiro Tsuyama, Masanori Obata, Fu-Jun Li, Xu Zheng, Yasuko Maki, Koji Miyamoto, Michio M. Kawano

Blood (2005) 105 (8): 3312–3318.

https://doi.org/10.1182/blood-2004-10-3915

Published: 2005

Journal Articles

DHEA Can Inhibit the Proliferation of Myeloma Cells and the IL-6 Production of Bone Marrow Mononuclear Cells from the Myeloma Patients.

Ken-ichiro Otsuyama, Zi Ma, Shangqin Liu, Fu-Jun Li, Saeid Abroun, Xu Zheng, Yasuko Maki, Naohiro Tsuyama, Masanori Obata, MD, Hideaki Ishikawa, MD, Michio M. Kawano, MD

Blood (2004) 104 (11): 2458.

https://doi.org/10.1182/blood.V104.11.2458.2458

Published: 2004

Journal Articles

Roles of CD19 Molecules That Suppress Proliferation and Induce Apoptosis in Human Myeloma Cells.

Xu Zheng, Hideaki Ishikawa, MD, Naohiro Tsuyama, Saeid Abroun, PhD, Shangqin Liu, Fu-Jun Li, Ken-ichiro Otsuyama, Zi Ma, Yasuko Maki, Msanori Obata, MD, Michio M. Kawano, MD

Blood (2004) 104 (11): 4843.

https://doi.org/10.1182/blood.V104.11.4843.4843

Published: 2004

Journal Articles

IL-6 Induced CD45RO, RB Translocation to Lipid Rafts in Myeloma Cells.

Fu-Jun Li, Naohiro Tsuyama, Hideaki Ishikawa, Masanori Obata, Saeid Abroun, Shangqin Liu, Kenichiro Otsuyama, Xu Zheng, Zi Ma, Yasuko Maki, Michio M. Kawano

Blood (2004) 104 (11): 3344.

https://doi.org/10.1182/blood.V104.11.3344.3344

Published: 2004

Journal Articles

CD45 Defines Signaling Thresholds Critical for Proliferation and Apoptosis in Myeloma Cells.

Shangqin Liu, Hideaki Ishikawa, MD, Naohiro Tsuyama, Saeid Abroun, PhD, Fu-Jun Li, Ken-ichiro Otsuyama, Xu Zheng, Zi Ma, Yasuko Maki, Masanori Obata, MD, Michio M. Kawano, MD

Blood (2004) 104 (11): 3345.

https://doi.org/10.1182/blood.V104.11.3345.3345

Published: 2004

Journal Articles

Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor α

Saeid Abroun, Hideaki Ishikawa, Naohiro Tsuyama, Shangqin Liu, Fu-Jun Li, Ken-ichiro Otsuyama, Xu Zheng, Masanori Obata, Michio M. Kawano

Blood (2004) 103 (6): 2291–2298.

https://doi.org/10.1182/blood-2003-07-2187

Published: 2004

Journal Articles

Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6

Hideaki Ishikawa, Naohiro Tsuyama, Saeid Abroun, Shangqin Liu, Fu-Jun Li, Osamu Taniguchi, Michio M. Kawano

Blood (2002) 99 (6): 2172–2178.

https://doi.org/10.1182/blood.V99.6.2172

Published: 2002

NARROW

Attempts to Induce t(11;14) during Redifferentiation of Normal B Cell-Derived Ips Cells to Study Myeloma-Initiating Cells

Normal B Cell-Derived iPSCs Capable of Inducing RAS Mutants and Aid to Explore Myeloma-Initiating Cells

Chromosomal Translocation t(11;14) Induced By the Cre-Loxp System in Normal B Cell-Derived Ips Cells for the Study of Myeloma-Initiating Cells

Introduction of Chromosomal Translocation t(11; 14) and a p53 Deletion into Normal B Cell-Derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells

Attempt to Prove the Existence of Abnormal B Lymphocyte As Myeloma-Initiating Cells from B Cell-Derived Induced Pluripotent Stem Cells

B Cell-Derived Induced Pluripotent Stem Cells Are Useful for Determining the Cellular Origin of Abnormal B Cells in Multiple Myeloma

Establishment of Induced Pluripotent Stem Cells from Lymph Node B Cells and Induction of Aid Expression in Their Differentiation into Hematopoietic Stem Cells

Cyclin D1 Overexpression Increases Chemosensitivity Via Prolonged S-Phase and TRAIL Signal in Myeloma Cell.

Cyclin D1 Overexpression Increases Chemosensitivity Via the Induction of Bim in Myeloma Cells.

Induction of Cyclin D1 Gene in Myeloma Cells Down-Regulates the Expression of Cyclin D2.

Galectin-1 Can Support the Survival of Human Myeloma Cells in In Vitro Culture.

A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma

Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells

DHEA Can Inhibit the Proliferation of Myeloma Cells and the IL-6 Production of Bone Marrow Mononuclear Cells from the Myeloma Patients.

Roles of CD19 Molecules That Suppress Proliferation and Induce Apoptosis in Human Myeloma Cells.

IL-6 Induced CD45RO, RB Translocation to Lipid Rafts in Myeloma Cells.

CD45 Defines Signaling Thresholds Critical for Proliferation and Apoptosis in Myeloma Cells.

Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor α

Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6

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American Society of Hematology

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American Society of Hematology

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