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Nathanael S. Gray, PhD
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Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2018-99-117372
Published: 2018
Journal Articles

Triple Degradation of BTK, IKZF1 and IKZF3 in B-Cell Malignancies

Sara Morrow, BA, Dennis Dobrovolsky, PhD, Eric Wang, PhD, Radosław P. Nowak, PhD, Katherine Donovan, PhD, Tyler Faust, PhD, Guang Yang, PhD, Zhengnian Li, PhD, Eric Fischer, Steven P Treon, MD PhD FRCP, David M Weinstock, MD, Nathanael S. Gray, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 263.
https://doi.org/10.1182/blood-2018-99-116895
Published: 2018
Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2018) 132 (Supplement 1): 40.
https://doi.org/10.1182/blood-2018-99-119171
Published: 2018
Journal Articles

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Julia Elizabeth Maxson, PhD, Abel L Melissa, BS, Jinhua Wang, PhD, Xianming Deng, PhD, Samuel B Luty, BS, Huahang Sun, MA, Julie Gorenstein, MS, Richard Middleton, PhD, Nathanael S. Gray, PhD, Brian J. Druker, Jeffrey W. Tyner, PhD
Journal: Blood
Blood (2014) 124 (21): 435.
https://doi.org/10.1182/blood.V124.21.435.435
Published: 2014
Journal Articles

Identification of Wee1 and IGF-1R As Novel Therapeutic Targets for Mutant RAS-Driven Acute Leukemia By Combinatory Chemical Screens

Atsushi Nonami, MDPhD, Chen Zhao, PhD, Liu Qingsong, PhD, Kristen Cowens, Amanda L. Christie, Yongfei Chen, Martin Sattler, PhD, Kwok-Kin Wang, MDPhD, Nathanael S. Gray, PhD, James D. Griffin, MD, Ellen L. Weisberg, PhD
Journal: Blood
Blood (2014) 124 (21): 3502.
https://doi.org/10.1182/blood.V124.21.3502.3502
Published: 2014
Journal Articles

Citron Rho-Interacting Serine/Threonine kinase (CIT) Is a Novel Therapeutic Target in Multiple Myeloma Cells

Yawara Kawano, MDPhD, Ilyas Sahin, MD, Michele Moschetta, MD, Jinhua Wang, Salomon Manier, MD, Siobhan Glavey, MD, Yuji Mishima, PhD, Katsutoshi Kokubun, PhD, Shokichi Tsukamoto, MD PhD, Antonio Sacco, BS, Kenneth C. Anderson, MD, Aldo M Roccaro, MD PhD, Nathanael S. Gray, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2014) 124 (21): 3430.
https://doi.org/10.1182/blood.V124.21.3430.3430
Published: 2014
Journal Articles

Serine/Threonine Kinase STK4 Is a Novel Target in Myeloma

Francesca Cottini, Teru Hideshima, MDPhD, Sara Buhrlage, PhD, Nathanael S. Gray, PhD, Paul G. Richardson, Giovanni Tonon, MDPhD, Kenneth C Anderson, MD
Journal: Blood
Blood (2014) 124 (21): 645.
https://doi.org/10.1182/blood.V124.21.645.645
Published: 2014
Journal Articles

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

Helena Mistry, Ph.D., Grace Hsieh, M.D., Sara Buhrlage, Ph.D, Min Huang, Ph.D., Eunmi Park, Ph.D., Gregory Cuny, Ph.D., Ilene Galinsky, ANP, Richard M. Stone, MD, Nathanael S Gray, PhD, Kalindi Parmar, PhD, Alan D. D'Andrea, MD
Journal: Blood
Blood (2013) 122 (21): 2906.
https://doi.org/10.1182/blood.V122.21.2906.2906
Published: 2013
Journal Articles

Using Small Molecules To Identify Critical Signaling Pathways Of Mutant N-RAS In Acute Leukemia Cells

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Jianming Zhang, PhD, Qingsong Liu, PhD, Matthew Patricell, PhD, Hojong Yoon, Amanda L. Christie, B.S., Amy M. Sauer, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S. Gray, PhD, James D. Griffin, MD
Journal: Blood
Blood (2013) 122 (21): 169.
https://doi.org/10.1182/blood.V122.21.169.169
Published: 2013
Journal Articles

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Yangsheng Zhou, MD, Lian Xu, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Zachary Hunter, Sara Buhrlage, Ph.D, Nathanael S Gray, PhD, Steven Peter Treon, MD, MA, PhD
Journal: Blood
Blood (2013) 122 (21): 4255.
https://doi.org/10.1182/blood.V122.21.4255.4255
Published: 2013
Journal Articles

Germinal Center Kinase Regulates The Proliferation and Survival Of Diffuse Large B-Cell Lymphoma

Julie Marie Matthews, PhD, Li Tan, PhD, Shruti Bhatt, MS, Matthew Patricelli, PhD, Tyzoon Nomanbhoy, PhD, Jianming Zhang, PhD, Xiaoyu Jiang, PhD, Yasodha Natkunam, MD, PhD, Hwan Geun Choi, PhD, Andrew J. Gentles, PhD, Ezequiel Martinez, MS, Daxing Zhu, MD, Jennifer Rose Chapman, MD, Ragini M Shyam, MD, Shideh Chinichian, MD, Ranjana H. Advani, MD, Sara Buhrlage, Ph.D, Dita Gratzinger, MD, PhD, Nathanael S Gray, PhD, Izidore S Lossos, MD
Journal: Blood
Blood (2013) 122 (21): 643.
https://doi.org/10.1182/blood.V122.21.643.643
Published: 2013
Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Takaomi Sanda, MD, PhD, Jeffrey W Tyner, PhD, Alejandro Gutierrez, MD, Vu N Ngo, PhD, Jason M Glover, MD, Bill H Chang, MD, PhD, Arla J Yost, Andrew P Weng, MD, PhD, Wenxue Ma, M.D., Ph.D., Jessica Tatarek, Angela G. Fleischman, MD, PhD, Yebin Ahn, Yandan Yang, PhD, Wenjun Zhou, Donna S. Neuberg, ScD, Richard Moriggl, PhD, Mathias Müller, DVM, Michelle Kelliher, PhD, Catriona Jamieson, MD, PhD, Nathanael S Gray, PhD, Louis M. Staudt, MD, PhD, Brian J. Druker, Thomas Look, MD
Journal: Blood
Blood (2012) 120 (21): 1470.
https://doi.org/10.1182/blood.V120.21.1470.1470
Published: 2012
Journal Articles

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Liu Qingsong, PhD, Jianming Zhang, PhD, Guillaume Adelmant, PhD, Jarrod A Marto, PhD, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S Gray, PhD, James D. Griffin, MD
Journal: Blood
Blood (2012) 120 (21): 2455.
https://doi.org/10.1182/blood.V120.21.2455.2455
Published: 2012
Journal Articles

Dissection of Bcr-abl Structural Domains Relating to Kinase Auto-Inhibition Using a Forward Mutational Screen with the Non-ATP Competitive Inhibitor GNF-2.

John T. Powers, PhD, Mohammad Azam, PhD, Nathanael S. Gray, PhD, George Q. Daley, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 1021.
https://doi.org/10.1182/blood.V110.11.1021.1021
Published: 2007
Journal Articles

A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue.

Mohammad Azam, PhD, Markus Seeliger, PhD, Nathanael S. Gray, PhD, John Kuriyan, PhD, George Q. Daley, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 223.
https://doi.org/10.1182/blood.V110.11.223.223
Published: 2007