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Journal Articles

Defining Mechanistic Responses to Different Vaso-Occlusive Triggers in Sickle Cell Disease: A Step Towards Personalized VOC Reversal Strategies

Lucas F.S. Gushiken, Sarah Liane Linguet, Erica M.F. Gotardo, Pamela L Brito, Flavia C. Leonardo, Laetitia Claer, Slim Azouzi, Caroline Le Van Kim, Fernando Ferreira Costa, Sandrine Laurance, Berengere Khoel, Nicola Conran

Blood (2024) 144 (Supplement 1): 2489.

https://doi.org/10.1182/blood-2024-193820

Published: 2024

Journal Articles

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Erica M.F. Gotardo, Lucas F.S. Gushiken, Pamela L Brito, Flavia C. Leonardo, Lidiane S. Torres, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Fernando Ferreira Costa, Nicola Conran

Blood (2023) 142 (Supplement 1): 2487.

https://doi.org/10.1182/blood-2023-181895

Published: 2023

Journal Articles

Unravelling the Mechanism behind Ineffective Erythropoiesis in Sickle Cell Disease: The Role of GATA-1

Sara El Hoss, Panicos Shangaris, John Brewin, Maria Eleni Psychogyiou, Cecilia Ng, Kypros Herodotos Nicolaides, Nicola Conran, David C Rees, John Strouboulis

Blood (2023) 142 (Supplement 1): 2458.

https://doi.org/10.1182/blood-2023-178851

Published: 2023

Journal Articles

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

Pamela L Brito, Erica M.F. Gotardo, Lucas F.S. Gushiken, Flavia C. Leonardo, Fernando Ferreira Costa, Nicola Conran

Blood (2023) 142 (Supplement 1): 1078.

https://doi.org/10.1182/blood-2023-189048

Published: 2023

Journal Articles

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Erica M.F. Gotardo, Lidiane S. Torres, Lucas F.S. Gushiken, Pamela L. Brito, Flavia C. Leonardo, Sergei Agoulnik, Jiri Kovarik, Andreas Bruederle, John Millholland, Alessandra Vitaliti, Irmgard Förster, Fernando Ferreira Costa, Nicola Conran

Blood (2022) 140 (Supplement 1): 8230–8232.

https://doi.org/10.1182/blood-2022-159020

Published: 2022

Journal Articles

Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice

Lidiane S. Torres, Erica M.F. Gotardo, Flávia Costa Leonardo, Pamela L. Brito, Irmgard Förster, Jiri Kovarik, Fernando Ferreira Costa, Nicola Conran

Blood (2021) 138 (Supplement 1): 856.

https://doi.org/10.1182/blood-2021-147436

Published: 2021

Journal Articles

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Erica M.F. Gotardo, PhD, Pamela L. Brito, M.Sc., Hanan Chweih, M.Sc., Flavia C. Leonardo, PhD, Fernando Ferreira Costa, MD PhD, Nicola Conran, PhD

Blood (2019) 134 (Supplement_1): 2263.

https://doi.org/10.1182/blood-2019-131741

Published: 2019

Journal Articles

Safe Use of Hydroxyurea in Sickle Cell Disease Patients Hospitalized for Painful Vaso-Occlusive Episodes: Results of the Randomized, Open-Label Helps Study

Nicola Conran, PhD, Kleber Yotsumoto Fertrin, MD PhD, Claudia de Alvarenga Maximo, MD, Thais Oliveira, B.Sc., Clarisse Lobo, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2019) 134 (Supplement_1): 2303.

https://doi.org/10.1182/blood-2019-130106

Published: 2019

Journal Articles

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Hanan Chweih, M.Sc., Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Pamela L. Brito, B.Sc, Guilherme G.O. Barbosa, PhD, Flavia Garcia, PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2354.

https://doi.org/10.1182/blood-2018-99-118633

Published: 2018

Journal Articles

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Carla F. Franco-Penteado, PhD, Mariana Gonçalves Oliveira, M.Sc., Edson Antunes, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2362.

https://doi.org/10.1182/blood-2018-99-118813

Published: 2018

Journal Articles

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Lidiane S. Torres, PhD, Lediana I. Miguel, M.Sc., Merav E. Shaul, PhD, Zvi G. Fridlender, MD PhD, Wilson A. Ferreira, Jr., PhD, Flavia C. Leonardo, PhD, Sara T. Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 2366.

https://doi.org/10.1182/blood-2018-99-118960

Published: 2018

Journal Articles

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Pamela L. Brito, B.Sc, Flavia C. Leonardo, PhD, Raquel Costa, PhD, Raquel Soares, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3608.

https://doi.org/10.1182/blood-2018-99-118416

Published: 2018

Journal Articles

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

Lediana I. Miguel, M.Sc., Lidiane S. Torres, PhD, Wilson A. Ferreira, Jr., PhD, Fernanda C. Z. Fabris, B.Sc., Flavia C. Leonardo, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2018) 132 (Supplement 1): 3610.

https://doi.org/10.1182/blood-2018-99-118974

Published: 2018

Journal Articles

The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis

Nicola Conran, PhD, Juliete A.F. Silva, PhD, Erica M.F. Gotardo, PhD, Hanan Chweih, M.Sc., Lediana I. Miguel, M.Sc., Flávia Costa Leonardo, PhD, Wilson A. Ferreira, Jr., PhD, Bo E. Hedlund, PhD, Howard L. Elford, PhD, Fernando F. Costa, MD, PhD

Blood (2018) 132 (Supplement 1): 1034.

https://doi.org/10.1182/blood-2018-99-119224

Published: 2018

Journal Articles

Rock Inhibitor Fasudil Reduces Leukocyte-Endothelium Interactions in the Microvasculature of a Sickle Cell Mouse Model of Allergic Inflammation

Athos Rodrigues Moraes, Hanan Chweih, BSc, Nicola Conran, PhD, Kleber Yotsumoto Fertrin, MD PhD, Fernando Ferreira Costa, MD PhD, Carla Fernanda Franco-Penteado, BSc, PhD

Blood (2017) 130 (Supplement 1): 961.

https://doi.org/10.1182/blood.V130.Suppl_1.961.961

Published: 2017

Journal Articles

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Rafaela Mendonça, BS, Karla P.V Ferro, PhD, Flávia Costa Leonardo, PhD, Juliete A.F. Silva, PhD, Fernando Vieira Pericole, MD PhD, Sara T Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 2233.

https://doi.org/10.1182/blood.V130.Suppl_1.2233.2233

Published: 2017

Journal Articles

Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia

Hanan Chweih, BSc, Juliete A.F. Silva, PhD, Wilson A. Ferreira, Jr., PhD, Pamela L. Brito, B.Sc, Erica M.F. Gotardo, PhD, Flavia C. Leonardo, PhD, Carla F Franco-Penteado, B.Sc. PhD, Fernando Ferreira Costa, PhD,MD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 540.

https://doi.org/10.1182/blood.V130.Suppl_1.540.540

Published: 2017

Journal Articles

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Juliete A.F. Silva, PhD, Hanan Chweih, BSc, Erica M.F. Gotardo, PhD, Wilson A. Ferreira, Jr., PhD, Carla F. Franco-Penteado, B.Sc. PhD, Camila B. Almeida, PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD

Blood (2017) 130 (Supplement 1): 3514.

https://doi.org/10.1182/blood.V130.Suppl_1.3514.3514

Published: 2017

Journal Articles

Heme Induces NLRP3 Inflammasome Formation in Primary Human Macrophages and May Propagate Hemolytic Inflammatory Processes By Inducing S100A8 Expression

Angelica A. Silveira, M.Sc., Clare Cunningham, PhD, Emma Corr, B.Sc., Wilson Alves Ferreira, Jr., PhD, Fernando F. Costa, MD, PhD, Camila B. Almeida, PhD, Nicola Conran, PhD, Aisling Dunne, PhD

Blood (2016) 128 (22): 1256.

https://doi.org/10.1182/blood.V128.22.1256.1256

Published: 2016

Journal Articles

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

Fernanda F.C. Fabris, Flavia C. Leonardo, PhD, Rodolfo Cancado, MD, PhD, Rafaela Mendonça, B.Sc., Angelica A. Silveira, M.Sc., Kleber Yotsumoto Fertrin, MD, PhD, Sara Teresinha Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD, Camila B. Almeida, PhD

Blood (2016) 128 (22): 1257.

https://doi.org/10.1182/blood.V128.22.1257.1257

Published: 2016

NARROW

Defining Mechanistic Responses to Different Vaso-Occlusive Triggers in Sickle Cell Disease: A Step Towards Personalized VOC Reversal Strategies

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Unravelling the Mechanism behind Ineffective Erythropoiesis in Sickle Cell Disease: The Role of GATA-1

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Safe Use of Hydroxyurea in Sickle Cell Disease Patients Hospitalized for Painful Vaso-Occlusive Episodes: Results of the Randomized, Open-Label Helps Study

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb -Dependent Pathway

The Ribonucleotide Reductase Inhibitor, Didox, Reduces the In Vivo Vascular Inflammation and Oxidative Stress Induced By Acute Hemolysis

Rock Inhibitor Fasudil Reduces Leukocyte-Endothelium Interactions in the Microvasculature of a Sickle Cell Mouse Model of Allergic Inflammation

Canonical Inflammasome Formation in Monocytes of Sickle Cell Anemia Patients

Role for Platelets in Mediating Neutrophil Recruitment in TNF-α Induced Vaso-Occlusive Processes in Animals with Sickle Cell Anemia

Combined Treatment with Hydroxyurea and a Phosphodiesterase 9 (PDE9) Inhibitor Decreases Hepatic Damage in an Animal Model of Sickle Cell Anemia

Heme Induces NLRP3 Inflammasome Formation in Primary Human Macrophages and May Propagate Hemolytic Inflammatory Processes By Inducing S100A8 Expression

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

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American Society of Hematology

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American Society of Hematology

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