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Journal Articles

A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): "Double Arm" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD, PhD, BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD

Blood (2020) 136 (Supplement 1): 41.

https://doi.org/10.1182/blood-2020-140642

Published: 2020

Journal Articles

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Watanabe Daisuke, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Kouhei Yamamoto, Takeo Fujiwara, MD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Tetsuya Fukuda, MD PhD, Ayako Arai, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata

Blood (2019) 134 (Supplement_1): 1690.

https://doi.org/10.1182/blood-2019-122652

Published: 2019

Journal Articles

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD

Blood (2019) 134 (Supplement_1): 1941.

https://doi.org/10.1182/blood-2019-121973

Published: 2019

Journal Articles

FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim

Ayako Nogami, MD PhD BPharm, Daisuke Watanabe, MD, Keigo Okada, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Toshikage Nagao, MD, PhD, Shuji Tohda, MD, PhD, Osamu Miura, MD, PhD

Blood (2019) 134 (Supplement_1): 1425.

https://doi.org/10.1182/blood-2019-123183

Published: 2019

Journal Articles

A Novel Cell Line, Tnet-2, Derived from "Triple-Negative" Essential Thrombocythemia

Satoru Aoyama, MD MMSc, Toshikage Nagao, MD PhD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Yoshihiro Umezawa, MD, Ken Watanabe, MD PhD, Masahide Yamamoto, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata, MD

Blood (2018) 132 (Supplement 1): 5493.

https://doi.org/10.1182/blood-2018-99-114457

Published: 2018

Journal Articles

Tumor Cells from EBV-Positive T- or NK-Cell Neoplasms Induce Differentiation and Activation of Macrophages By Secreting Humoral Factors

Akiho Tsuzura, Mayumi Yoshimori, Kanoko Konno, Ken-Ichi Imadome, PhD, Erika Onozawa, Ryunosuke Ohkawa, PhD, Minoru Tozuka, PhD, Osamu Miura, MD, PhD, Ayako Arai, MD, PhD

Blood (2017) 130 (Supplement 1): 4026.

https://doi.org/10.1182/blood.V130.Suppl_1.4026.4026

Published: 2017

Journal Articles

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Keigo Okada, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Osamu Miura, MD, PhD

Blood (2017) 130 (Supplement 1): 2531.

https://doi.org/10.1182/blood.V130.Suppl_1.2531.2531

Published: 2017

Journal Articles

FLT3-ITD Confers Resistance to Bortezomib By Protecting the mTOR/4EBP1 Pathway through Activation of STAT5 and Induction of Pim-1 Expression

Ayako Nogami, MD PhD, Keigo Okada, MD, Gaku Oshikawa, MD PhD, Shinya Ishida, MD, Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Tetsuya Kurosu, MD PhD, Osamu Miura, MD PhD

Blood (2015) 126 (23): 1270.

https://doi.org/10.1182/blood.V126.23.1270.1270

Published: 2015

Journal Articles

Gene Expression Profiling of Primary Vitreoretinal Lymphoma

Ayako Arai, MD PhD, Hiroshi Takase, MD PhD, Kouhei Yamamoto, MD PhD, Hiroki Akiyama, MD, Manabu Mochizuki, MD PhD, Osamu Miura, MD PhD

Blood (2015) 126 (23): 1239.

https://doi.org/10.1182/blood.V126.23.1239.1239

Published: 2015

Journal Articles

Systemic Following Intravitreal MTX Administration Prevents CNS Infiltration of Primary Intraocular Lymphoma

Hiroki Akiyama, MD, Hiroshi Takase, MDPhD, Fumito Kubo, MD, Tohru Miki, MD PhD, Masahide Yamamoto, MD PhD, Makoto Tomita, PhD, Manabu Mochizuki, MDPhD, Osamu Miura, MD PhD, Ayako Arai, MD PhD

Blood (2014) 124 (21): 3053.

https://doi.org/10.1182/blood.V124.21.3053.3053

Published: 2014

Journal Articles

STAT3 Is Activated By EBV in T or NK Cells Leading to Development of EBV-T/NK-Lymphoproliferative Disorders

Honami Komatsu, Ken-Ichi Imadome, PhD, Haruna Shibayama, Tomotaka Yada, Momoko Yamada, Kouhei Yamamoto, MDPhD, Takatoshi Koyama, MD PhD, Shigeyoshi Fujiwara, MD PhD, Osamu Miura, MD PhD, Ayako Arai, MD PhD

Blood (2014) 124 (21): 3026.

https://doi.org/10.1182/blood.V124.21.3026.3026

Published: 2014

Journal Articles

Protooncogene MYB Activates the Transcription of ROR1 in B Cell Malignancies

Ken Watanabe, MDPhD, Megumi Iida, Shihoko Suwa, MD, Miyu Kato, M.P.A.S, Osamu Miura, MD PhD, Tetsuya Fukuda, MD PhD

Blood (2014) 124 (21): 3292.

https://doi.org/10.1182/blood.V124.21.3292.3292

Published: 2014

Journal Articles

Management Of Pregnancy In Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report Of 10 Cases From The Working Group On Pregnancy Of The Japan PNH Study Group

Kensuke Usuki, MD PhD, Akio Urabe, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Naoyuki Miyasaka, MD, PhD, Osamu Miura, MD, PhD, Eriko Morishita, MD, PhD, Nobuyoshi Arima, MD, PhD, Yasuyoshi Morita, MD, PhD, Kaichi Nishiwaki, MD, Haruhiko Ninomiya, MD, PhD, Akihiko Gotoh, MD, PhD, Shinsaku Imashuku, MD, Tsutomu Shichishima, MD, PhD, Jun-ichi Nishimura, MD, PhD, Yuzuru Kanakura

Blood (2013) 122 (21): 2480.

https://doi.org/10.1182/blood.V122.21.2480.2480

Published: 2013

Journal Articles

Epstein–Barr Virus Induces Activation-Induced Cytidine Deaminase Expression in T or NK Cells Leading to Mutagenesis and Development of Lymphoma

Ayako Arai, MD, PhD, Masato Horino, Ken-Ichi Imadome, PhD, Kohsuke Imai, MD, PhD, Honami Komatsu, Ludan Wang, MD, Go Matsuda, Kasumi Hamazaki, Morito Kurata, MD, PhD, Tetsuya Kurosu, MD, PhD, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD

Blood (2013) 122 (21): 1765.

https://doi.org/10.1182/blood.V122.21.1765.1765

Published: 2013

Journal Articles

L-Asparaginase Monotherapy for T- and NK-Cell Type of Chronic Active Epstein-Barr Virus Infection in Adults: A Pilot Study

Ayako Arai, MD, PhD, Minako Jinta, MD, Ken-Ichi Imadome, PhD, Mayumi Yoshimori, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD

Blood (2011) 118 (21): 4953.

https://doi.org/10.1182/blood.V118.21.4953.4953

Published: 2011

Journal Articles

High-Resolution Genomic Copy Number Profiling of Primary Intraocular Lymphomas Using SNP Microarrays

Ludan Wang, MD, Aiko Sato-Otsubo, PhD, Sunao Sugita, MD, PhD, Hiroshi Takase, MD, PhD, Manabu Mochizuki, MD, PhD, Yoshihiko Usui, MD, PhD, Hiroshi Goto, MD, PhD, Osamu Miura, MD, PhD, Seishi Ogawa, MD, PhD, Ayako Arai, MD, PhD

Blood (2011) 118 (21): 1354.

https://doi.org/10.1182/blood.V118.21.1354.1354

Published: 2011

Journal Articles

NF-κB Is Constitutively Activated in EBV-Infected T or NK Cells and Can Be a Molecular Target for EBV-Positive T/NK-Cell Lymphoproliferative Disease Treatment

Ayako Arai, MD, PhD, Mayumi Takahashi, Ken-Ichi Imadome, PhD, Takatoshi Koyama, MD, PhD, Yasunori Saitoh, MD, PhD, Shoji Yamaoka, MD, PhD, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD

Blood (2010) 116 (21): 1998.

https://doi.org/10.1182/blood.V116.21.1998.1998

Published: 2010

Journal Articles

CD137/4-1BB Is Inducibly Expressed On CLL B Cells through CD40 Signaling.

Tetsuya Fukuda, MD, PhD, Yukana Nakaima, MSc, Aya Kasubata, Ken Watanabe, Takatoshi Koyama, MD, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD, Osamu Miura, MD, PhD

Blood (2009) 114 (22): 1266.

https://doi.org/10.1182/blood.V114.22.1266.1266

Published: 2009

Journal Articles

CD137 Expression Is Enhanced in EBV-Infected T or NK Cells by Viral Protein LMP1 and Mediates Anti-Apoptotic Intracellular Signaling through NF-ĸB Activation.

Ayako Arai, MD, PhD, Ken-ichi Imadome, PhD, Mayumi Takahashi, Koichi Naka, Tetsuya Fukuda, MD, PhD, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD

Blood (2009) 114 (22): 1929.

https://doi.org/10.1182/blood.V114.22.1929.1929

Published: 2009

Journal Articles

ASK1 Is Activated by Treatment with Arsenic Trioxide through Accumulation of Reactive Oxygen Species and May Suppress Apoptosis through NF-kappaB in Leukemia Cells.

Ayako Arai, MD, PhD, Weihua Yan, Hidenori Ichijo, M.D.,Ph.D., Osamu Miura, M.D.,Ph.D.

Blood (2006) 108 (11): 4394.

https://doi.org/10.1182/blood.V108.11.4394.4394

Published: 2006

NARROW

A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): "Double Arm" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim

A Novel Cell Line, Tnet-2, Derived from "Triple-Negative" Essential Thrombocythemia

Tumor Cells from EBV-Positive T- or NK-Cell Neoplasms Induce Differentiation and Activation of Macrophages By Secreting Humoral Factors

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

FLT3-ITD Confers Resistance to Bortezomib By Protecting the mTOR/4EBP1 Pathway through Activation of STAT5 and Induction of Pim-1 Expression

Gene Expression Profiling of Primary Vitreoretinal Lymphoma

Systemic Following Intravitreal MTX Administration Prevents CNS Infiltration of Primary Intraocular Lymphoma

STAT3 Is Activated By EBV in T or NK Cells Leading to Development of EBV-T/NK-Lymphoproliferative Disorders

Protooncogene MYB Activates the Transcription of ROR1 in B Cell Malignancies

Management Of Pregnancy In Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report Of 10 Cases From The Working Group On Pregnancy Of The Japan PNH Study Group

Epstein–Barr Virus Induces Activation-Induced Cytidine Deaminase Expression in T or NK Cells Leading to Mutagenesis and Development of Lymphoma

L-Asparaginase Monotherapy for T- and NK-Cell Type of Chronic Active Epstein-Barr Virus Infection in Adults: A Pilot Study

High-Resolution Genomic Copy Number Profiling of Primary Intraocular Lymphomas Using SNP Microarrays

NF-κB Is Constitutively Activated in EBV-Infected T or NK Cells and Can Be a Molecular Target for EBV-Positive T/NK-Cell Lymphoproliferative Disease Treatment

CD137/4-1BB Is Inducibly Expressed On CLL B Cells through CD40 Signaling.

CD137 Expression Is Enhanced in EBV-Infected T or NK Cells by Viral Protein LMP1 and Mediates Anti-Apoptotic Intracellular Signaling through NF-ĸB Activation.

ASK1 Is Activated by Treatment with Arsenic Trioxide through Accumulation of Reactive Oxygen Species and May Suppress Apoptosis through NF-kappaB in Leukemia Cells.

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American Society of Hematology

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American Society of Hematology

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