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Journal Articles

MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Daisuke Watanabe, MD, PhD, Hiroki Akiyama, MD, PhD, Kouhei Yamamoto, Takeo Fujiwara, MD, Emiko Sakaida, MDPhD, Yoko Edahiro, MD PhD, Misa Imai, PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Norihiko Kawamata, MD, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-139162

Published: 2020

Journal Articles

A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): "Double Arm" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD, PhD, BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD

Blood (2020) 136 (Supplement 1): 41.

https://doi.org/10.1182/blood-2020-140642

Published: 2020

Journal Articles

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Watanabe Daisuke, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Kouhei Yamamoto, Takeo Fujiwara, MD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Tetsuya Fukuda, MD PhD, Ayako Arai, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata

Blood (2019) 134 (Supplement_1): 1690.

https://doi.org/10.1182/blood-2019-122652

Published: 2019

Journal Articles

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD

Blood (2019) 134 (Supplement_1): 1941.

https://doi.org/10.1182/blood-2019-121973

Published: 2019

Journal Articles

A Novel Cell Line, Tnet-2, Derived from "Triple-Negative" Essential Thrombocythemia

Satoru Aoyama, MD MMSc, Toshikage Nagao, MD PhD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Yoshihiro Umezawa, MD, Ken Watanabe, MD PhD, Masahide Yamamoto, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata, MD

Blood (2018) 132 (Supplement 1): 5493.

https://doi.org/10.1182/blood-2018-99-114457

Published: 2018

Journal Articles

Genome Editing of the Murine Calreticulin Gene Using the CRISPR/Cas9 and CPF1 System

Daisuke Watanabe, MD, Shunichiro Yasuda, MD, Norihiko Kawamata, MD

Blood (2017) 130 (Supplement 1): 4966.

https://doi.org/10.1182/blood.V130.Suppl_1.4966.4966

Published: 2017

Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 452.

https://doi.org/10.1182/blood.V128.22.452.452

Published: 2016

Journal Articles

Characterization of Multimerization Domains of Chimeric Transcription Factors in Leukemia

Norihiko Kawamata, Mutsuko Minata, Xin Wang, H. Phillip Koeffler, MD, PhD, Keiich Itakura

Blood (2012) 120 (21): 1276.

https://doi.org/10.1182/blood.V120.21.1276.1276

Published: 2012

Journal Articles

Comprehensive Profiling of Somatic Mutations Which Define Primary Disease and Relapse in Various Acute Leukemia Subtypes

Blood (2012) 120 (21): 783.

https://doi.org/10.1182/blood.V120.21.783.783

Published: 2012

Journal Articles

Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes

Gabriela B. Iwanski, MD, Nils H. Thoennissen, MD, Joy Nakitandwe, BSc, MSc, PhD, Patricia Lin, Norihiko Kawamata, Rahul Nahar, Parham Ramezani-Rad, Shann-Ching Chen, Sheila Shurtleff, PhD, Daniel Nowak, MD, Christian Ruckert, Martin Dugas, MD, Carsten Bokemeyer, MD, Grazia Fazio, Andrea Biondi, Professor, MD, Giovanni Cazzaniga, PhD, James R. Downing, MD, Markus Müschen, H. Phillip Koeffler, MD

Blood (2010) 116 (21): 3231.

https://doi.org/10.1182/blood.V116.21.3231.3231

Published: 2010

Journal Articles

Dominant Negative Form of PAX5 Is Generated by Multimerization of Its DNA Binding Domain

Norihiko Kawamata, Mario Pennella, Jennifer Woo, Arnold Berk, H. Phillip Koeffler, MD

Blood (2010) 116 (21): 25.

https://doi.org/10.1182/blood.V116.21.25.25

Published: 2010

Journal Articles

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome–negative myeloproliferative neoplasms

Blood (2010) 115 (14): 2882–2890.

https://doi.org/10.1182/blood-2009-07-235119

Published: 2010

Includes: Supplemental data

Journal Articles

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

Daniel Nowak, Seishi Ogawa, Markus Müschen, Motohiro Kato, Norihiko Kawamata, Antonie Meixel, Verena Nowak, Han S. Kim, Sharon Kang, Ronald Paquette, Mi-Sook Chang, Nils H. Thoennissen, Max Mossner, Wolf-Karsten Hofmann, Alexander Kohlmann, Tamara Weiss, Torsten Haferlach, Claudia Haferlach, H. Phillip Koeffler

Blood (2010) 115 (5): 1049–1053.

https://doi.org/10.1182/blood-2009-03-210377

Published: 2010

Includes: Supplemental data

Journal Articles

The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.

Daniel Nowak, MD, Norihiko Kawamata, MD, PhD, Birte Niebuhr, PhD, Verena Nowak, Maximilian Mossner, Rahul R Nahar, Nils Heinrich Thoennissen, MD, Gabriela B. Iwanski, MD, Carol Stocking, PhD, Martin Dugas, MD, PhD, Wolf Karsten Hofmann, MD, PhD, Markus Müschen, MD, PhD, Phillip H Koeffler, MD, PhD

Blood (2009) 114 (22): 1284.

https://doi.org/10.1182/blood.V114.22.1284.1284

Published: 2009

Journal Articles

PAX5/TEL Exhibits a Dominant-Negative Role by Inhibiting the Expression of Genes Involved in BCR Signalling and Suppressing the Binding of Wild Type PAX5 to Its Direct Target Gene CD79A (mb-1) in a human Pre-B ALL Cell Line.

Gabriela B. Iwanski, MD, Nils Heinrich Thoennissen, MD, PohYeen Lor, Norihiko Kawamata, MD, PhD, Daniel Nowak, MD, Grazia Fazio, PhD, Andrea Biondi, MD, Giovanni Gazzaniga, PhD, H. Phillip Koeffler, MD

Blood (2009) 114 (22): 3455.

https://doi.org/10.1182/blood.V114.22.3455.3455

Published: 2009

Journal Articles

Unique Gain-of-Function of Mutated c-CBL Tumor Suppresor in Myeloid Neoplasms.

Blood (2009) 114 (22): 2970.

https://doi.org/10.1182/blood.V114.22.2970.2970

Published: 2009

Journal Articles

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations

Tadayuki Akagi, Lee-Yung Shih, Motohiro Kato, Norihiko Kawamata, Go Yamamoto, Masashi Sanada, Ryoko Okamoto, Carl W. Miller, Der-Cherng Liang, Seishi Ogawa, H. Phillip Koeffler

Blood (2009) 113 (8): 1741–1748.

https://doi.org/10.1182/blood-2007-12-130260

Published: 2009

Includes: Supplemental data

Journal Articles

Genomic Changes Associated with Leukemic Transformation of Myeloproliferative Disorders.

Nils Heinrich Thoennissen, Norihiko Kawamata, MD, Terra L Lasho, MT(ASCP), Tamara Weiss, Daniel Nowak, Motohiro Kato, Junko Takita, MD, Masashi Sanada, Torsten Haferlach, MD, Ruben A. Mesa, MD, FACP, Ayalew Tefferi, MD, C. Müller-Tidow, MD, Seishi Ogawa, MD, PhD, Phillip H Koeffler

Blood (2008) 112 (11): 3371.

https://doi.org/10.1182/blood.V112.11.3371.3371

Published: 2008

Journal Articles

High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations

Daniel Nowak, MD, Norihiko Kawamata, MD, Tadayuki Akagi, PhD, Ryoko Okamoto, PhD, Nils Thoennissen, MD, Wolf-Karsten Hofmann, MD, PhD, Motohiro Kato, PhD, Torsten Haferlach, MD, PhD, Seishi Ogawa, MD, PhD, H. Phillip Koeffler, MD, PhD

Blood (2008) 112 (11): 3182.

https://doi.org/10.1182/blood.V112.11.3182.3182

Published: 2008

Journal Articles

Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD

Sanada Masashi, MD, Shih Lee Yung, MD, PhD, Takahiro Suzuki, MD, PhD, Motohiro Kato, MD, Mamiko Yanagimoto Sakata, MD, PhD, Keiki Kumano, MD, PhD, Norihiko Kawamata, MD, PhD, Junko Takita, MD, PhD, Hiraku Mori, MD, PhD, Mineo Kurokawa, MD, PhD, Shigeru Chiba, MD, PhD, Mitsuhiro Omine, MD, PhD, H. Phillip Koeffler, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2008) 112 (11): 855.

https://doi.org/10.1182/blood.V112.11.855.855

Published: 2008

NARROW

MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations

A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): "Double Arm" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

A Novel Cell Line, Tnet-2, Derived from "Triple-Negative" Essential Thrombocythemia

Genome Editing of the Murine Calreticulin Gene Using the CRISPR/Cas9 and CPF1 System

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Characterization of Multimerization Domains of Chimeric Transcription Factors in Leukemia

Comprehensive Profiling of Somatic Mutations Which Define Primary Disease and Relapse in Various Acute Leukemia Subtypes

Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes

Dominant Negative Form of PAX5 Is Generated by Multimerization of Its DNA Binding Domain

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome–negative myeloproliferative neoplasms

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.

PAX5/TEL Exhibits a Dominant-Negative Role by Inhibiting the Expression of Genes Involved in BCR Signalling and Suppressing the Binding of Wild Type PAX5 to Its Direct Target Gene CD79A (mb-1) in a human Pre-B ALL Cell Line.

Unique Gain-of-Function of Mutated c-CBL Tumor Suppresor in Myeloid Neoplasms.

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations

Genomic Changes Associated with Leukemic Transformation of Myeloproliferative Disorders.

High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations

Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD

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American Society of Hematology

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American Society of Hematology

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