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Journal Articles

Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms

Angela Stoddart, Joy Nakitandwe, Shann-Ching Chen, James R. Downing, Michelle M. Le Beau

Blood (2015) 126 (26): 2899–2901.

https://doi.org/10.1182/blood-2015-10-673228

Published: 2015

Journal Articles

Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia

Blood (2015) 126 (23): 692.

https://doi.org/10.1182/blood.V126.23.692.692

Published: 2015

Journal Articles

Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes

Jasmine C. Wong, PhD, Kelley Weinfurtner, BA, Pilar Alzamora, Scott C. Kogan, MD, Michael R. Burgess, MD PhD, Yan Zhang, PhD, Joy Nakitandwe, PhD, Jing Ma, PhD, Jinjun Cheng, MB, MS, Shann-Ching Chen, PhD, Johanna Flach, Damien Reynaud, PhD, Emmanuelle Passegue, PhD, James R Downing, MD, Kevin Shannon, MD

Blood (2014) 124 (21): 3247.

https://doi.org/10.1182/blood.V124.21.3247.3247

Published: 2014

Journal Articles

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Monique Dail, PhD, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, PhD., Shann-Ching Chen, PhD, Keiko Akagi, Leslie Lee, Jon C. Aster, MD, PhD, Warren S. Pear, MD, PhD, Deepak Sampath, PhD, James R. Downing, MD, Kevin Shannon, MD

Blood (2013) 122 (21): 2677.

https://doi.org/10.1182/blood.V122.21.2677.2677

Published: 2013

Journal Articles

High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1 -Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia

Michelle Churchman, Ph.D., Jonathan Low, Ph.D., Debbie Payne-Turner, Shann-Ching Chen, PhD, Jing Ma, PhD, Mark J. Althoff, Faiyaz Notta, PhD, John E. Dick, PhD, Laura Janke, DVM, PhD, Rodney Kiplin Guy, Ph.D, Taosheng Chen, Ph.D., Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA

Blood (2013) 122 (21): 172.

https://doi.org/10.1182/blood.V122.21.172.172

Published: 2013

Journal Articles

Integrated Genomic and Mutational Profiling Of Adolescent and Young Adult ALL Identifies a High Frequency Of BCR-ABL1 -Like ALL with Very Poor Outcome

Blood (2013) 122 (21): 825.

https://doi.org/10.1182/blood.V122.21.825.825

Published: 2013

Journal Articles

Development and Validation Of a Highly Sensitive and Specific Gene Expression Classifier To Prospectively Screen and Identify B-Precursor Acute Lymphoblastic Leukemia (ALL) Patients With a Philadelphia Chromosome-Like (“ Ph-like ” or “ BCR-ABL1-Like ”) Signature For Therapeutic Targeting and Clinical Intervention

Blood (2013) 122 (21): 826.

https://doi.org/10.1182/blood.V122.21.826.826

Published: 2013

Journal Articles

Genomic Characterization and Experimental Modeling Of BCR-ABL1 -Like Acute Lymphoblastic Leukemia

Blood (2013) 122 (21): 232.

https://doi.org/10.1182/blood.V122.21.232.232

Published: 2013

Journal Articles

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

Angell Shieh, Ashley F. Ward, Kegan L. Donlan, Emily R. Harding-Theobald, Jin Xu, Charles G. Mullighan, Chao Zhang, Shann-Ching Chen, Xiaoping Su, James R. Downing, Gideon E. Bollag, Kevin M. Shannon

Blood (2013) 121 (24): 4884–4893.

https://doi.org/10.1182/blood-2012-05-432252

Published: 2013

Includes: Supplemental data

Journal Articles

Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project

Blood (2011) 118 (21): 757.

https://doi.org/10.1182/blood.V118.21.757.757

Published: 2011

Journal Articles

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Jinghui Zhang, PhD, Li Ding, PhD, Linda Holmfeldt, PhD, Gang Wu, PhD, Susan L. Heatley, Ph.D., Debbie Payne-Turner, John Easton, PhD, Xiang Chen, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Charles Lu, PhD, Shann-Ching Chen, PhD, Racquel Collins-Underwood, PhD, Jing Ma, PhD, Kathryn G. Roberts, PhD, Stanley Pounds, PhD, Lei Wei, PhD, Anatoly Ulyanov, PhD, Jared Becksfort, Pankaj Gupta, Robert Huether, PhD, Richard Kriwacki, PhD, Daniel McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, MS, Cheng Cheng, PhD, Stefan Roberts, Michael Barbato, Dario Campana, MD, PhD, Elaine Coustan-Smith, MS, William E. Evans, PharmD, Sheila A Shurtleff, PhD, Maria Kleppe, Jan Cools, PhD, Kristin Shimano, Michelle L. Hermiston, MD, PhD, Sergei Doulatov, PhD, Kolja Eppert, PhD, Elisa Laurenti, PhD, Faiyaz Notta, PhD, John E Dick, PhD, Giuseppe Basso, MD PhD, Stephen P. Hunger, MD, Mignon L Loh, MD, Meenakshi Devidas, PhD, Brent L. Wood, MD, PhD, Stuart S. Winter, MD, Kimberly Dunsmore, MD, Robert S. Fulton, MS, Lucinda A. Fulton, MS, Xin Hong, PhD, Christopher C. Harris, BS, David J. Dooling, PhD, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, Ching-Hon Pui, MD, Susana C. Raimondi, PhD, Clayton W Naeve, PhD, Timothy J Ley, MD, Elaine R Mardis, PhD, Richard K Wilson, PhD, James R Downing, MD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2011) 118 (21): 68.

https://doi.org/10.1182/blood.V118.21.68.68

Published: 2011

Journal Articles

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

Alejandro Gutierrez, Alex Kentsis, Takaomi Sanda, Linda Holmfeldt, Shann-Ching Chen, Jianhua Zhang, Alexei Protopopov, Lynda Chin, Suzanne E. Dahlberg, Donna S. Neuberg, Lewis B. Silverman, Stuart S. Winter, Stephen P. Hunger, Stephen E. Sallan, Shan Zha, Frederick W. Alt, James R. Downing, Charles G. Mullighan, A. Thomas Look

Blood (2011) 118 (15): 4169–4173.

https://doi.org/10.1182/blood-2010-11-318873

Published: 2011

Includes: Supplemental data

Journal Articles

Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes

Gabriela B. Iwanski, MD, Nils H. Thoennissen, MD, Joy Nakitandwe, BSc, MSc, PhD, Patricia Lin, Norihiko Kawamata, Rahul Nahar, Parham Ramezani-Rad, Shann-Ching Chen, Sheila Shurtleff, PhD, Daniel Nowak, MD, Christian Ruckert, Martin Dugas, MD, Carsten Bokemeyer, MD, Grazia Fazio, Andrea Biondi, Professor, MD, Giovanni Cazzaniga, PhD, James R. Downing, MD, Markus Müschen, H. Phillip Koeffler, MD

Blood (2010) 116 (21): 3231.

https://doi.org/10.1182/blood.V116.21.3231.3231

Published: 2010

Journal Articles

The Role of Dominant-Negative IKAROS Mutations In the Pathogenesis and Treatment Responsiveness of BCR-ABL1 positive Acute Lymphoblastic Leukemia

J. Racquel Collins-Underwood, PhD, Nidal Boulos, PhD, Debbie Payne-Turner, Shann-Ching Chen, Ph.D., Richard Williams, MD, PhD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2010) 116 (21): 540.

https://doi.org/10.1182/blood.V116.21.540.540

Published: 2010

Journal Articles

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

Maria E. Figueroa, MD, Shann-Ching Chen, Ph.D., Anna K. Andersson, PhD, Wei Liu, Ph.D., Cheng Cheng, Ph.D., Letha A Phillips, Yushan Li, James R. Downing, MD, Ari M. Melnick, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc

Blood (2010) 116 (21): 537.

https://doi.org/10.1182/blood.V116.21.537.537

Published: 2010

Journal Articles

Acute Lymphoblastic Leukemia-Associated PAX5 Mutations Induce Aberrant B Cell Development

Joy Nakitandwe, PhD., Shann-Ching Chen, PhD., Noel T. Lenny, PhD., Christopher B. Miller, PhD., Xiaoping Su, PhD., Charles G. Mullighan, MD, PhD., James R. Downing, MD.

Blood (2010) 116 (21): 10.

https://doi.org/10.1182/blood.V116.21.10.10

Published: 2010

NARROW

Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms

Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia

Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1 -Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia

Integrated Genomic and Mutational Profiling Of Adolescent and Young Adult ALL Identifies a High Frequency Of BCR-ABL1 -Like ALL with Very Poor Outcome

Genomic Characterization and Experimental Modeling Of BCR-ABL1 -Like Acute Lymphoblastic Leukemia

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes

The Role of Dominant-Negative IKAROS Mutations In the Pathogenesis and Treatment Responsiveness of BCR-ABL1 positive Acute Lymphoblastic Leukemia

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

Acute Lymphoblastic Leukemia-Associated PAX5 Mutations Induce Aberrant B Cell Development

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American Society of Hematology

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American Society of Hematology

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