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Journal Articles

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia

Blood blood.2024024300.

https://doi.org/10.1182/blood.2024024300

Published: 2024

Includes: Supplemental data

Journal Articles

Choline Kinase a Is Required for Alkylating Agent Resistance in T-Cell Acute Lymphoblastic Leukemia

Anais Barthe, Kimberly Bodaar, Aaron Issaian, Eric Aboagye, Angelo D'Alessandro, Alejandro Gutierrez

Blood (2022) 140 (Supplement 1): 2258.

https://doi.org/10.1182/blood-2022-162508

Published: 2022

Journal Articles

IRX3 Oncogene Activation in T-ALL through Enhancer Hijacking Caused By fto Intron 8 Deletions

Blood (2022) 140 (Supplement 1): 1009–1010.

https://doi.org/10.1182/blood-2022-162930

Published: 2022

Journal Articles

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

Laura Hinze, Sabine Schreek, Andre Zeug, PhD, Evgeni Ponimaskin, PhD, Roxane Labrosse, MD FRCPC, James Degar, Gabriela Chiosis, PhD, Sung-Yun Pai, MD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Martin Stanulla, MD, Alejandro Gutierrez, MD

Blood (2019) 134 (Supplement_1): 169.

https://doi.org/10.1182/blood-2019-126633

Published: 2019

Journal Articles

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Blood (2018) 132 (Supplement 1): 889.

https://doi.org/10.1182/blood-2018-99-113518

Published: 2018

Journal Articles

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, PhD, Sacher Joshua, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Daniel E. Bauer, MD PhD, Florence Wagner, PhD, Kimberly Stegmaier, MD, Alejandro Gutierrez, MD

Blood (2018) 132 (Supplement 1): 891.

https://doi.org/10.1182/blood-2018-99-113794

Published: 2018

Journal Articles

An Off-the-Shelf™ Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies

Blood (2017) 130 (Supplement 1): 844.

https://doi.org/10.1182/blood.V130.Suppl_1.844.844

Published: 2017

Journal Articles

The Fanconi Pathway in Pediatric T-Cell Acute Lymphoblastic Leukemia

Blood (2017) 130 (Supplement 1): 2722.

https://doi.org/10.1182/blood.V130.Suppl_1.2722.2722

Published: 2017

Journal Articles

Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-Cell Acute Lymphoblastic Leukemia

Melissa A. Burns, MD, Zi Wei Liao, Gayle P. Pouliot, MD PhD, Kristen E. Stevenson, MS, Donna S. Neuberg, ScD, Aaron R. Thorner, PhD, Matthew D. Ducar, MS, Emily A. Silverman, Stephen P. Hunger, MD, Mignon L. Loh, MD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent Wood, MDPhD, Meenakshi Devidas, PhD, Marian H. Harris, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Alejandro Gutierrez, MD

Blood (2017) 130 (Supplement 1): 367.

https://doi.org/10.1182/blood.V130.Suppl_1.367.367

Published: 2017

Journal Articles

PRC2 Mutations Induce Resistance to Conventional Chemotherapy By Inhibiting Mitochondrial Apoptosis in T-Cell Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 604.

https://doi.org/10.1182/blood.V128.22.604.604

Published: 2016

Journal Articles

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

Mark A. Murakami, MD MA, Alexandra N. Christodoulou, M.S., Amanda L Christie, B.S., Tiffany DeSouza, B.S., Abner Louissaint, Jr., MD PhD, Una Vojinovic, B.S., Raphael Koch, MD, Loretta S. Li, MD, Scott P. Kallgren, PhD, Prakash Rao, PhD, Johannes Köster, PhD, Raga Vadhi, M.S., Eilene Duberow, B.S., Elizabeth A. Morgan, MD, Hongjun Wang, Samia S. Ahmed, Katharine L. Majewski, Marina Konopleva, MD PhD, Jerome Tamburini, MD, PhD, Alejandro Gutierrez, MD, Michelle Kelliher, PhD, Julia Etchin, PhD, Irmela Jeremias, MD, Andrew P. Weng, MD PhD, Andrew L Kung, MD PhD, Andrew A Lane, MD PhD, Francine Garnache-Ottou, PhD, Shai Izraeli, MD Prof, Eric Jacobsen, MD, Ilene Galinsky, ANP, Richard M. Stone, MD, Marian H. Harris, MD PhD, David M. Dorfman, MD PhD, Jon C Aster, MDPhD, Henry Long, PhD, Lewis B. Silverman, MD, David M Weinstock, MD

Blood (2015) 126 (23): 3252.

https://doi.org/10.1182/blood.V126.23.3252.3252

Published: 2015

Journal Articles

An X-linked tumor suppressor in T-ALL

Ingrid M. Ariës, Alejandro Gutierrez

Blood (2015) 125 (1): 3–4.

https://doi.org/10.1182/blood-2014-11-607838

Published: 2015

Journal Articles

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Justine E. Roderick, Jessica Tesell, Leonard D. Shultz, Michael A. Brehm, Dale L. Greiner, Marian H. Harris, Lewis B. Silverman, Stephen E. Sallan, Alejandro Gutierrez, A. Thomas Look, Jun Qi, James E. Bradner, Michelle A. Kelliher

Blood (2014) 123 (7): 1040–1050.

https://doi.org/10.1182/blood-2013-08-522698

Published: 2014

Includes: Supplemental data

Journal Articles

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

Blood (2012) 120 (21): 3558.

https://doi.org/10.1182/blood.V120.21.3558.3558

Published: 2012

Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Blood (2012) 120 (21): 1470.

https://doi.org/10.1182/blood.V120.21.1470.1470

Published: 2012

Journal Articles

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

Shuyun Rao, Sang-Yun Lee, Alejandro Gutierrez, Jacqueline Perrigoue, Roshan J. Thapa, Zhigang Tu, John R. Jeffers, Michele Rhodes, Stephen Anderson, Tamas Oravecz, Stephen P. Hunger, Roman A. Timakhov, Rugang Zhang, Siddharth Balachandran, Gerard P. Zambetti, Joseph R. Testa, A. Thomas Look, David L. Wiest

Blood (2012) 120 (18): 3764–3773.

https://doi.org/10.1182/blood-2012-03-415349

Published: 2012

Includes: Supplemental data

Journal Articles

NOTCH1 Signaling Defines a Leukemia Initiating Cell Population in T-Cell Acute Lymphoblastic Leukemia

Wenxue Ma, M.D., Ph.D., Kristen M. Smith, Ph.D., Alejandro Gutierrez, M.D., Heather S. Leu, B.S., Qingfei Jiang, Ph.D., Christina C.N. Wu, Ph.D., Alice Y. Shih, B.S., Angela C. Court-Recart, M.S., Anil Sadarangani, Ph.D., Daniel J. Goff, B.S., Ping Wei, Ph.D., A. Thomas Look, M.D., Catriona H.M. Jamieson, M.D., Ph.D.

Blood (2011) 118 (21): 1507.

https://doi.org/10.1182/blood.V118.21.1507.1507

Published: 2011

Journal Articles

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

Angela G. Fleischman, MD, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Samuel B Luty, Stephanie G Willis, A. Thomas Look, M.D., Brian J. Druker, Jeffrey W Tyner, PhD

Blood (2011) 118 (21): 74.

https://doi.org/10.1182/blood.V118.21.74.74

Published: 2011

Journal Articles

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

Alejandro Gutierrez, Alex Kentsis, Takaomi Sanda, Linda Holmfeldt, Shann-Ching Chen, Jianhua Zhang, Alexei Protopopov, Lynda Chin, Suzanne E. Dahlberg, Donna S. Neuberg, Lewis B. Silverman, Stuart S. Winter, Stephen P. Hunger, Stephen E. Sallan, Shan Zha, Frederick W. Alt, James R. Downing, Charles G. Mullighan, A. Thomas Look

Blood (2011) 118 (15): 4169–4173.

https://doi.org/10.1182/blood-2010-11-318873

Published: 2011

Includes: Supplemental data

Journal Articles

A Notch Mutational Hierarchy Among Human T-ALL Leukemia Stem Cells.

Wenxue Ma, MD, PhD, Alejandro Gutierrez, MD, Daniel Goff, BS, Angela Court-Recart, MS, Alice Shih, BS, Qingfei Jiang, Ph.D., Anil Sadarangani, Ph.D., Christina Wu, Ph.D., Christina Jamieson, Ph.D., Mitchell Diccianni, PhD, Ping Wei, Ph.D., Todd Van Arsdale, PhD, Thomas Look, MD, Catriona Jamieson, MD, PhD

Blood (2010) 116 (21): 1034.

https://doi.org/10.1182/blood.V116.21.1034.1034

Published: 2010

NARROW

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia

Choline Kinase a Is Required for Alkylating Agent Resistance in T-Cell Acute Lymphoblastic Leukemia

IRX3 Oncogene Activation in T-ALL through Enhancer Hijacking Caused By fto Intron 8 Deletions

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

An Off-the-Shelf™ Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies

The Fanconi Pathway in Pediatric T-Cell Acute Lymphoblastic Leukemia

Hedgehog Pathway Mutations Drive Oncogenic Transformation in High-Risk T-Cell Acute Lymphoblastic Leukemia

PRC2 Mutations Induce Resistance to Conventional Chemotherapy By Inhibiting Mitochondrial Apoptosis in T-Cell Acute Lymphoblastic Leukemia

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

An X-linked tumor suppressor in T-ALL

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

NOTCH1 Signaling Defines a Leukemia Initiating Cell Population in T-Cell Acute Lymphoblastic Leukemia

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

A Notch Mutational Hierarchy Among Human T-ALL Leukemia Stem Cells.

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American Society of Hematology

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American Society of Hematology

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