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James Degar
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Journal Articles

Inducible Phase Separation of GSK3α As a Mechanism for Asparaginase Resistance in Acute Leukemias

Laura Hinze, Sabine Schreek, Andre Zeug, PhD, Evgeni Ponimaskin, PhD, Roxane Labrosse, MD FRCPC, James Degar, Gabriela Chiosis, PhD, Sung-Yun Pai, MD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Martin Stanulla, MD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 169.
https://doi.org/10.1182/blood-2019-126633
Published: 2019
Journal Articles

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Kimberly Bodaar, MD, Ingrid M. Aries, PhD MSc, Salmaan Karim, Triona Ni Chonghaile, PhD BSc, Melissa A. Burns, MD, Laura Hinze, Maren Pfirrmann, James Degar, Jack Landrigan, Sebastian Balbach, Sofie Peirs, PhD, Bjorn Menten, PhD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Meenakshi Devidas, PhD, Mignon L. Loh, MD, Stephen P. Hunger, MD, David T Teachey, MD, Karen R. Rabin, MD PhD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent Wood, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Pieter Van Vlierberghe, PhD, Stuart H. Orkin, MD, Birgit Knoechel, MDPhD, Anthony Letai, MD PhD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 889.
https://doi.org/10.1182/blood-2018-99-113518
Published: 2018
Journal Articles

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, PhD, Sacher Joshua, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Daniel E. Bauer, MD PhD, Florence Wagner, PhD, Kimberly Stegmaier, MD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 891.
https://doi.org/10.1182/blood-2018-99-113794
Published: 2018
Journal Articles

The Fanconi Pathway in Pediatric T-Cell Acute Lymphoblastic Leukemia

Gayle P. Pouliot, MD PhD, Melissa A. Burns, MD, James Degar, Chau Vo, Lisa Moreau, Justine E. Roderick, PhD, Bose Kochupurakkal, PhD, Sofie Peirs, PhD, Bjorn Menten, PhD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Marian H. Harris, MD PhD, Kristen E. Stevenson, MS, Donna S. Neuberg, ScD, David M. Weinstock, MD, Andrew P. Weng, MD PhD, Michelle Kelliher, PhD, Pieter Van Vlierberghe, PhD, Alan D. D'Andrea, MD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2722.
https://doi.org/10.1182/blood.V130.Suppl_1.2722.2722
Published: 2017