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Sunniyat Rahman
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Journal Articles

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia

Sunniyat Rahman, Gianna Bloye, Nadine Farah, Jonas Demeulemeester, Joana R Costa, David O'Connor, Rachael Pocock, Tanya Rapoz-D'Silva, Adam Turna, Lingyi Wang, Soo Wah Lee, Adele K Fielding, Juliette Roels, Roman Jaksik, Małgorzata Dawidowska, Pieter Van Vlierberghe, Suzana Hadjur, Jim R Hughes, James Davies, Alejandro Gutierrez, Michelle Kelliher, Peter Van Loo, Mark A. Dawson, Marc R. Mansour
Journal: Blood
Blood blood.2024024300.
https://doi.org/10.1182/blood.2024024300
Published: 2024
Includes: Supplemental data
Journal Articles

Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

David O’Connor, Jose Espejo Valle-Inclán, Lucia Conde, Gianna Bloye, Sunniyat Rahman, Joana R. Costa, Jack Bartram, Stuart Adams, Gary Wright, Hillary Elrick, Kerry Wall, Sara Dyer, Christopher Howell, Galina Jigoulina, Javier Herrero, Isidro Cortes-Ciriano, Anthony V. Moorman, Marc R. Mansour
Journal: Blood
Blood (2024) 143 (10): 933–937.
https://doi.org/10.1182/blood.2023021906
Published: 2024
Includes: Supplemental data
Journal Articles

IRX3 Oncogene Activation in T-ALL through Enhancer Hijacking Caused By fto Intron 8 Deletions

Sunniyat Rahman, Nadine Farah, Jonas Demeulemeester, Joana R Costa, Gianna Bloye, David O'Connor, Rachael Pocock, Adam Turna, SooWah Lee, Adele K. Fielding, Juliette Roels, Małgorzata Dawidowska, Pieter Van Vlierberghe, Suzana Hadjur, Alejandro Gutierrez, Michelle A Kelliher, Simone Riva, Jim R. Hughes, James O.J. Davies, Peter Van Loo, Mark A. Dawson, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 1009–1010.
https://doi.org/10.1182/blood-2022-162930
Published: 2022
Journal Articles

The Clinico-Genomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

David O'Connor, Jonas Demeulemeester, Lucia Conde, Amy A. Kirkwood, Kent Fung, Foteini Papaleonidopoulou, Gianna Bloye, Nadine Farah, Sunniyat Rahman, Jeremy Hancock, Caroline Bateman, Sarah Inglott, Jon Mee, Javier Herrero, Peter Van Loo, Anthony V. Moorman, Ajay Vora, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 1720–1721.
https://doi.org/10.1182/blood-2022-165308
Published: 2022
Journal Articles

The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL

Joana R Costa, David O'Connor, Nurkaiyisah Anuar, Sunniyat Rahman, Nivedita Singh, Zhaodong China, Tanya Rapoz-D'Silva, Yang Li, Kent Fung, Sara Hyseni, Stephen Henderson, George Morrow, Yanping Guo, Javier Herrero, Richard Jenner, Dennis Keppei, A. Thomas Look, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 3046–3047.
https://doi.org/10.1182/blood-2022-166396
Published: 2022
Journal Articles

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

Paul M. Maciocia, Patrycja A. Wawrzyniecka, Nicola C. Maciocia, Amy Burley, Thaneswari Karpanasamy, Sam Devereaux, Malika Hoekx, David O’Connor, Theresa Leon, Tanya Rapoz-D’Silva, Rachael Pocock, Sunniyat Rahman, Giuseppe Gritti, Diana C. Yánez, Susan Ross, Tessa Crompton, Owen Williams, Lydia Lee, Martin A. Pule, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (1): 25–37.
https://doi.org/10.1182/blood.2021013648
Published: 2022
Includes: Supplemental data
Journal Articles

Synthetic Lethal Screening Identifies CHK1 Inhibition As an Exploitable Vulnerability in EZH2 Deficient T-ALL

Theresa E. Leon, PhD MSc, BSc, Tanya Rapoz-D'Silva, BSc, MSc, Sunniyat Rahman, MBiochem, DIC, PhD, Michael Magnussen, BSc, MSc, Nadine Farah, MBBChir, MA, MRCP, FRCPath, Jose A. Guerra-Assunção, BSc, PhD, Rajeev Gupta, MB.ChB, PhD FRCP, FRCPath, Elisabeth P. Nacheva, MD PhD, Javier Herrero, PhD, David C. Linch, FRCP, Marc R. Mansour, MD PhD FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 1325.
https://doi.org/10.1182/blood.V130.Suppl_1.1325.1325
Published: 2017
Journal Articles

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Clinical Trials & Observations Brief Report
Sunniyat Rahman, Michael Magnussen, Theresa E. León, Nadine Farah, Zhaodong Li, Brian J. Abraham, Krisztina Z. Alapi, Rachel J. Mitchell, Tom Naughton, Adele K. Fielding, Arnold Pizzey, Sophia Bustraan, Christopher Allen, Teodora Popa, Karin Pike-Overzet, Laura Garcia-Perez, Rosemary E. Gale, David C. Linch, Frank J. T. Staal, Richard A. Young, A. Thomas Look, Marc R. Mansour
Journal: Blood
Blood (2017) 129 (24): 3221–3226.
https://doi.org/10.1182/blood-2016-09-742148
Published: 2017
Includes: Supplemental data
Journal Articles

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Sunniyat Rahman, PhD DIC, MBiochem, Michael Magnussen, MSc, BSc, Theresa E. León, PhD MSc, BSc, Nadine Farah, FRCPath, MBBChir, MA, MRCP, Brian J. Abraham, PhD BSc, Zhaodong Li, PhD, Krisztina Z. Alapi, PhD MSc, BSc, Rachel J. Mitchell, MSc, Bsc, Tom Naughton, MSc, BSc, Adele K. Fielding, MB BS, PhD FRCP, FRCPath, Arnold Pizzey, Sophia Bustraan, BSc, Christopher Allen, BSc, Rosemary E. Gale, PhD BSc, David C. Linch, MD MRCP, MB BCh, BA, Richard A. Young, PhD BS, A. Thomas Look, MD, Marc R Mansour, MBChB, MRCP, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 733.
https://doi.org/10.1182/blood.V128.22.733.733
Published: 2016