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Journal Articles

A human genome editing–based MLL :: AF4 ALL model recapitulates key cellular and molecular leukemogenic features

Blood (2023) 142 (20): 1752–1756.

https://doi.org/10.1182/blood.2023020858

Published: 2023

Includes: Supplemental data

Journal Articles

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

Blood (2022) 140 (1): 25–37.

https://doi.org/10.1182/blood.2021013648

Published: 2022

Includes: Supplemental data

Journal Articles

Targeted Inactivation of the c-Myb Oncogene through Integrated Network Analysis

Jasper de Boer, PhD, Vanessa Walf-Vorderwuelbecke, PhD, Gareth Williams, PhD, Sujith Samarasinghe, MD PhD, Phil Ancliff, MD, Nicholas Goulden, MD PhD, Owen Williams, PhD

Blood (2015) 126 (23): 2561.

https://doi.org/10.1182/blood.V126.23.2561.2561

Published: 2015

Journal Articles

The Role of SMAD7 Downstream of TEL-AML1 Signalling in t(12;21) Acute Lymphoblastic Leukemia

Aishwarya Sundaresh, Miss, Maurizio Mangolini, Dr, Jasper de Boer, Dr, Mike Hubank, Dr, Nicholas Goulden, Dr, Owen Williams, PhD

Blood (2015) 126 (23): 4823.

https://doi.org/10.1182/blood.V126.23.4823.4823

Published: 2015

Journal Articles

Targeting Reptin Function in Acute Myeloid Leukaemia

Elena Armenteros-Monterroso, M.Phil., Lu Zhao, Dr, Jasper de Boer, PhD, Owen Williams, PhD

Blood (2015) 126 (23): 4824.

https://doi.org/10.1182/blood.V126.23.4824.4824

Published: 2015

Journal Articles

Drug Induced MLL Fusion Degradation Via Hsp90 Inhibition

Sandra Cantilena, MPhil, Nicholas Goulden, MD PhD, Owen Williams, PhD, Jasper de Boer, PhD

Blood (2015) 126 (23): 4850.

https://doi.org/10.1182/blood.V126.23.4850.4850

Published: 2015

Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2014) 124 (21): 5193.

https://doi.org/10.1182/blood.V124.21.5193.5193

Published: 2014

Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 2545.

https://doi.org/10.1182/blood.V122.21.2545.2545

Published: 2013

Journal Articles

STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia

Maurizio Mangolini, Jasper de Boer, Vanessa Walf-Vorderwülbecke, Rob Pieters, Monique L. den Boer, Owen Williams

Blood (2013) 122 (4): 542–549.

https://doi.org/10.1182/blood-2012-11-465252

Published: 2013

Includes: Supplemental data

Journal Articles

Frat2 mediates the oncogenic activation of Rac by MLL fusions

Vanessa Walf-Vorderwülbecke, Jasper de Boer, Sarah J. Horton, Renée van Amerongen, Natalie Proost, Anton Berns, Owen Williams

Blood (2012) 120 (24): 4819–4828.

https://doi.org/10.1182/blood-2012-05-432534

Published: 2012

Includes: Supplemental data

Journal Articles

PAX5 Is a Frequently Altered Transcription Factor In Genetically Unclassified Childhood Common/B-Cell Precursor Acute Lymphoblastic Leukemia

Iryna Stasevich, Sarah Inglott, Philip Ancliff, Owen Williams, Helena Kempski

Blood (2011) 118 (21): 1458.

https://doi.org/10.1182/blood.V118.21.1458.1458

Published: 2011

Journal Articles

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

Jonathan Bond, Daniel P. Gale, Thomas Connor, Stuart Adams, Jasper de Boer, Duncan M. Gascoyne, Owen Williams, Patrick H. Maxwell, Philip J. Ancliff

Blood (2011) 117 (13): 3699–3701.

https://doi.org/10.1182/blood-2010-12-327569

Published: 2011

Journal Articles

Connectivity Mapping Identifies HDAC Inhibitors as Suitable Candidates for the Treatment of t(4;11)-Positive Acute Lymphoblastic Leukemia In Infants

Dominique JPM Stumpel, Pauline Schneider, Lidija Seslija, Hikari Osaki, Owen Williams, Rob Pieters, MD, PhD, Ronald Stam, PhD

Blood (2010) 116 (21): 3222.

https://doi.org/10.1182/blood.V116.21.3222.3222

Published: 2010

Journal Articles

High Expression of the Ca 2+ -Binding Proteins S100A8 and S100A9 Cause Glucocorticoid Resistance in MLL -Rearranged Infant Acute Lymphoblastic Leukemia.

Jill Hagelstein, Pauline Schneider, Jasper de Boer, Esther Hulleman, PhD, Owen Williams, Rob Pieters, Ronald W. Stam, Ph.D.

Blood (2009) 114 (22): 729.

https://doi.org/10.1182/blood.V114.22.729.729

Published: 2009

Journal Articles

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams

Blood (2009) 113 (20): 4922–4929.

https://doi.org/10.1182/blood-2008-07-170480

Published: 2009

Includes: Supplemental data

Journal Articles

CBFβ is critical for AML1-ETO and TEL-AML1 activity

Liya Roudaia, Matthew D. Cheney, Ekaterina Manuylova, Wei Chen, Michelle Morrow, Sangho Park, Chung-Tsai Lee, Prabhjot Kaur, Owen Williams, John H. Bushweller, Nancy A. Speck

Blood (2009) 113 (13): 3070–3079.

https://doi.org/10.1182/blood-2008-03-147207

Published: 2009

Journal Articles

Acute Myeloid Leukemia Induced by MLL-ENL Is Cured by Oncogene Ablation despite Acquisition of Complex Genetic Abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams

Blood (2008) 112 (11): 3109.

https://doi.org/10.1182/blood.V112.11.3109.3109

Published: 2008

Journal Articles

TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity

Michelle Morrow, Sarah Horton, Dimitris Kioussis, Hugh J. M. Brady, Owen Williams

Blood (2004) 103 (10): 3890–3896.

https://doi.org/10.1182/blood-2003-10-3695

Published: 2004

Includes: Supplemental data

NARROW

A human genome editing–based MLL :: AF4 ALL model recapitulates key cellular and molecular leukemogenic features

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

Targeted Inactivation of the c-Myb Oncogene through Integrated Network Analysis

The Role of SMAD7 Downstream of TEL-AML1 Signalling in t(12;21) Acute Lymphoblastic Leukemia

Targeting Reptin Function in Acute Myeloid Leukaemia

Drug Induced MLL Fusion Degradation Via Hsp90 Inhibition

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia

Frat2 mediates the oncogenic activation of Rac by MLL fusions

PAX5 Is a Frequently Altered Transcription Factor In Genetically Unclassified Childhood Common/B-Cell Precursor Acute Lymphoblastic Leukemia

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

Connectivity Mapping Identifies HDAC Inhibitors as Suitable Candidates for the Treatment of t(4;11)-Positive Acute Lymphoblastic Leukemia In Infants

High Expression of the Ca 2+ -Binding Proteins S100A8 and S100A9 Cause Glucocorticoid Resistance in MLL -Rearranged Infant Acute Lymphoblastic Leukemia.

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

CBFβ is critical for AML1-ETO and TEL-AML1 activity

Acute Myeloid Leukemia Induced by MLL-ENL Is Cured by Oncogene Ablation despite Acquisition of Complex Genetic Abnormalities

TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity

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American Society of Hematology

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ASH Publications

American Society of Hematology

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