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Journal Articles

TP53 Aberrant B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Are Uniquely Sensitive to a Combination of Pyrimidine De Novo Synthesis Blockade and Replication Checkpoint Inhibition

Gawin R. Stoll, Dorette Van Ingen Schenau, Willem P. J. Cox, Ziqin Tang, Emmely M. Wagener, Laurens T. van der Meer, Frank N. van Leeuwen

Blood (2023) 142 (Supplement 1): 4189.

https://doi.org/10.1182/blood-2023-179159

Published: 2023

Journal Articles

Loss of p53 Impairs Death Receptor Expression and Confers Resistance to CD19-Directed CAR T-Cell Therapy in B-Cell Precursor Acute Lymphoblastic Leukemia

Willem P. J. Cox, Noel M. M. Dautzenberg, Linde Dekker, Tesa Klenovšek, Marliek van Hoesel, Gawin R. Stoll, Roland P. Kuiper, Laurens T. van der Meer, Friso G. J. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

Blood (2023) 142 (Supplement 1): 598.

https://doi.org/10.1182/blood-2023-177911

Published: 2023

Journal Articles

MLL ( KMT2A)- rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy

Trisha Tee, Titine Ruiter, Danique Wajon, Shuiyan Wu, Ahmed Dahaoui, Dorette S van Ingen Schenau, Laurens T van der Meer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 6343–6344.

https://doi.org/10.1182/blood-2022-159450

Published: 2022

Journal Articles

The Prognostic Effect of IKZF1 Deletions in ETV6 :: RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Anna Østergaard, Amir Enshaei, Rob Pieters, Ajay Vora, Martin A. Horstmann, Gabriele Escherich, Bertil Johansson, Mats Heyman, Kjeld Schmiegelow, Peter M. Hoogerbrugge, Monique L. den Boer, Roland P. Kuiper, Anthony V. Moorman, Judith M. Boer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 3483–3485.

https://doi.org/10.1182/blood-2022-157431

Published: 2022

Journal Articles

Mutational Mechanisms in Pediatric Acute Lymphoblastic Leukemia with Multiple Relapses

Cédric G van der Ham, Stefan H Lelieveld, Željko Antic, Marley Yeong, Lianne C Suurenbroek, Dorette S van Ingen Schenau, Lennart A. Kester, Liset Westera, Edwin Sonneveld, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Frank N van Leeuwen, Roland P. Kuiper

Blood (2022) 140 (Supplement 1): 3463–3464.

https://doi.org/10.1182/blood-2022-159410

Published: 2022

Journal Articles

Histone Deacetylase Inhibition Restores Therapy Response in TP53 mutated Acute Lymphoblastic Leukemia to Chemotherapy

Willem Cox, Miriam Butler, Dorette S van Ingen Schenau, Nadia Anderson, Lieke de Groot, Laurens T van der Meer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 3132–3133.

https://doi.org/10.1182/blood-2022-157118

Published: 2022

Journal Articles

IKZF1 Deletions Induce Resistance to AraC in BCP-ALL Reversible By CDK8/19 Inhibition

Britt M T Vervoort, Miriam Butler, Dorette van Ingen Schenau, Vincent H.J. van der Velden, Beat Bornhauser, Jean-Pierre Bourquin, Laurens T van der Meer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 3465–3466.

https://doi.org/10.1182/blood-2022-162246

Published: 2022

Journal Articles

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

Miriam Butler, Dorette S. van Ingen Schenau, Jiangyan Yu, Silvia Jenni, Maria P. Dobay, Rico Hagelaar, Britt M. T. Vervoort, Trisha M. Tee, Fieke W. Hoff, Jules P. Meijerink, Steven M. Kornblau, Beat Bornhauser, Jean-Pierre Bourquin, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen

Blood (2021) 138 (23): 2383–2395.

https://doi.org/10.1182/blood.2021011787

Published: 2021

Includes: Supplemental data

Journal Articles

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Zeljko Antic, MD, Jiangyan Yu, MSc, Simon V. van Reijmersdal, Renske Kuiper, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD

Blood (2016) 128 (22): 4072.

https://doi.org/10.1182/blood.V128.22.4072.4072

Published: 2016

Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD

Blood (2015) 126 (23): 247.

https://doi.org/10.1182/blood.V126.23.247.247

Published: 2015

Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 3768.

https://doi.org/10.1182/blood.V126.23.3768.3768

Published: 2015

Journal Articles

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Laurens T Van Der Meer, PhD, Jiangyan Yu, MSc, Miriam Butler, MSc, Jolien M R van der Meer, MSc, Roland P Kuiper, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 2629.

https://doi.org/10.1182/blood.V126.23.2629.2629

Published: 2015

Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD

Blood (2015) 126 (23): 696.

https://doi.org/10.1182/blood.V126.23.696.696

Published: 2015

Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 905.

https://doi.org/10.1182/blood.V126.23.905.905

Published: 2015

Journal Articles

Effect of IKZF1 Deletions on Signal Transduction Pathways in Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Naomi E van der Sligte, Frank JG Scherpen, Arja ter Elst, PhD, Victor Guryev, PhD, Frank N van Leeuwen, PhD, Evelina SJM de Bont, MD PhD

Blood (2014) 124 (21): 3770.

https://doi.org/10.1182/blood.V124.21.3770.3770

Published: 2014

Journal Articles

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurensia Yuniati, MSc, Jorn Havinga, MSc, Felice Tirone, PhD, Jean-Pierre Rouault, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD

Blood (2014) 124 (21): 4311.

https://doi.org/10.1182/blood.V124.21.4311.4311

Published: 2014

Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2014) 124 (21): 5193.

https://doi.org/10.1182/blood.V124.21.5193.5193

Published: 2014

Journal Articles

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Jiangyan Yu, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD

Blood (2014) 124 (21): 2397.

https://doi.org/10.1182/blood.V124.21.2397.2397

Published: 2014

Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3587.

https://doi.org/10.1182/blood.V124.21.3587.3587

Published: 2014

Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3630.

https://doi.org/10.1182/blood.V124.21.3630.3630

Published: 2014

NARROW

TP53 Aberrant B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Are Uniquely Sensitive to a Combination of Pyrimidine De Novo Synthesis Blockade and Replication Checkpoint Inhibition

Loss of p53 Impairs Death Receptor Expression and Confers Resistance to CD19-Directed CAR T-Cell Therapy in B-Cell Precursor Acute Lymphoblastic Leukemia

MLL ( KMT2A)- rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy

The Prognostic Effect of IKZF1 Deletions in ETV6 :: RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Mutational Mechanisms in Pediatric Acute Lymphoblastic Leukemia with Multiple Relapses

Histone Deacetylase Inhibition Restores Therapy Response in TP53 mutated Acute Lymphoblastic Leukemia to Chemotherapy

IKZF1 Deletions Induce Resistance to AraC in BCP-ALL Reversible By CDK8/19 Inhibition

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Effect of IKZF1 Deletions on Signal Transduction Pathways in Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

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American Society of Hematology

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American Society of Hematology

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