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Liesbeth van Emst
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Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 905.
https://doi.org/10.1182/blood.V126.23.905.905
Published: 2015
Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 5193.
https://doi.org/10.1182/blood.V124.21.5193.5193
Published: 2014
Journal Articles

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurensia Yuniati, MSc, Jorn Havinga, MSc, Felice Tirone, PhD, Jean-Pierre Rouault, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD
Journal: Blood
Blood (2014) 124 (21): 4311.
https://doi.org/10.1182/blood.V124.21.4311.4311
Published: 2014
Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 2545.
https://doi.org/10.1182/blood.V122.21.2545.2545
Published: 2013
Journal Articles

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Laurens T. van der Meer, PhD, Laurensia Yuniati, MSc, Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Manon Alkema, Caroline Rodenbach, Blanca Scheijen, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 3796.
https://doi.org/10.1182/blood.V122.21.3796.3796
Published: 2013
Journal Articles

Tumor Suppressors BTG1 and BTG2 Fulfill Both Unique and Overlapping Functions During Normal B Lymphocyte Development

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Jørn Havinga, MSc, Jean-Pierre Rouault, PhD, Felice Tirone, PhD, Peter M. Hoogerbrugge, MD, PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2012) 120 (21): 1303.
https://doi.org/10.1182/blood.V120.21.1303.1303
Published: 2012
Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2011) 118 (21): 399.
https://doi.org/10.1182/blood.V118.21.399.399
Published: 2011
Journal Articles

A Key Role for Tumor Suppressor BTG1 In the Regulation of Metabolic Stress Responses: Implications for Asparaginase Resistance In Pediatric Acute Lymphoblastic Leukemia.

Laurens van der Meer, Marloes Levers, Liesbeth van Emst, Joost C. van Galen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD, Peter Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2010) 116 (21): 1028.
https://doi.org/10.1182/blood.V116.21.1028.1028
Published: 2010
Journal Articles

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

Joost C. van Galen, Roland P. Kuiper, Liesbeth van Emst, Marloes Levers, Esther Tijchon, Blanca Scheijen, Esmé Waanders, Simon V. van Reijmersdal, Christian Gilissen, Ad Geurts van Kessel, Peter M. Hoogerbrugge, Frank N. van Leeuwen
Journal: Blood
Blood (2010) 115 (23): 4810–4819.
https://doi.org/10.1182/blood-2009-05-223081
Published: 2010
Includes: Supplemental data
Journal Articles

BTG1, a Gene Frequently Deleted in Pre-B ALL, Controls Glucocorticoid Receptor-Mediated Gene Expression.

Frank N. van Leeuwen, PhD, Joost Casper van Galen, PhD, Roland P. Kuiper, PhD, Liesbeth van Emst, Marloes R Levers, Esther Tijchon, Msc, Blanca Scheijen, Esmee Waanders, PhD, Simon V van Reijmersdal, Christian Gillissen, Msc., Ad Geurts van Kessel, Peter M. Hoogerbrugge
Journal: Blood
Blood (2009) 114 (22): 3458.
https://doi.org/10.1182/blood.V114.22.3458.3458
Published: 2009
Journal Articles

BTG1 Controls Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia by Regulating Nuclear Receptor-Mediated Transcription.

Joost C. van Galen, MSc, Roland P. Kuiper, PhD, Liesbeth van Emst, BSc, Marloes R. Levers, BSc, Simon V. van Reijmersdal, BSc, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2008) 112 (11): 2262.
https://doi.org/10.1182/blood.V112.11.2262.2262
Published: 2008
Journal Articles

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1

Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth van Emst, Simon van Reijmersdal, Willemijn Wissink, Theo de Witte, Joop H. Jansen, Bert A. Van der Reijden
Journal: Blood
Blood (2007) 110 (9): 3128–3135.
https://doi.org/10.1182/blood-2006-11-058602
Published: 2007
Includes: Supplemental data
Journal Articles

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth Van Emst, Theo de Witte, Joop H. Jansen, Bert A. van der Reijden
Journal: Blood
Blood (2006) 109 (1): 100–108.
https://doi.org/10.1182/blood-2006-02-003590
Published: 2006
Journal Articles

The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells

Jurgen A.F. Marteijn, Liesbeth van Emst, Claudia A.J. Erpelinck-Verschueren, Gorica Nikoloski, Aswin Menke, Theo de Witte, Bob Löwenberg, Joop H. Jansen, Bert A. van der Reijden
Journal: Blood
Blood (2005) 106 (13): 4114–4123.
https://doi.org/10.1182/blood-2005-04-1450
Published: 2005
Includes: Supplemental data
Journal Articles

The Ubiquitin Ligase Triad1 Is Involved in Myelopoiesis and Interacts with the Transcriptional Repressors Gfi1 and Gfi1b.

Bert A. Van der Reijden, PhD, Jurgen A.F. Marteijn, Liesbeth Van Emst, Theo De Witte, PhD, MD, Joop H. Jansen, PhD
Journal: Blood
Blood (2004) 104 (11): 64.
https://doi.org/10.1182/blood.V104.11.64.64
Published: 2004
Journal Articles

A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease

Clinical Trials & Observations
Ypke V. J. M. van Oosterhout, Liesbeth van Emst, Anton V. M. B. Schattenberg, Wil J. M. Tax, Dirk J. Ruiter, Hergen Spits, Fokke M. Nagengast, Roos Masereeuw, Sabine Evers, Theo de Witte, Frank W. M. B. Preijers
Journal: Blood
Blood (2000) 95 (12): 3693–3701.
https://doi.org/10.1182/blood.V95.12.3693
Published: 2000