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Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD

Blood (2015) 126 (23): 247.

https://doi.org/10.1182/blood.V126.23.247.247

Published: 2015

Journal Articles

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Jiangyan Yu, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD

Blood (2014) 124 (21): 2397.

https://doi.org/10.1182/blood.V124.21.2397.2397

Published: 2014

Journal Articles

Exome Sequencing and Ultra-Deep Sequencing of Paired Diagnosis, Remission and Relapse Samples Reveals the Clonal Diversity and Treatment-Induced Evolution of Childhood Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, BSc, Marc M Hahn, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD

Blood (2012) 120 (21): 126.

https://doi.org/10.1182/blood.V120.21.126.126

Published: 2012

Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD

Blood (2011) 118 (21): 399.

https://doi.org/10.1182/blood.V118.21.399.399

Published: 2011

Journal Articles

Exome Sequencing of Late Recurrence T-Cell Acute Lymphoblastic Leukemia in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes

Esmé Waanders, PhD, Vincent H.J. van der Velden, PhD, Tomasz Szczepanski, Lisenka E.L.M. Vissers, PhD, Joep de Ligt, MSc, Christian Gilissen, Anke A.H. van Dijk, BSc, Simon V. van Reijmersdal, BSc, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Jacques J.M. van Dongen, PhD, Roland P. Kuiper, PhD

Blood (2011) 118 (21): 755.

https://doi.org/10.1182/blood.V118.21.755.755

Published: 2011

Journal Articles

A Key Role for Tumor Suppressor BTG1 In the Regulation of Metabolic Stress Responses: Implications for Asparaginase Resistance In Pediatric Acute Lymphoblastic Leukemia.

Laurens van der Meer, Marloes Levers, Liesbeth van Emst, Joost C. van Galen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD, Peter Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD

Blood (2010) 116 (21): 1028.

https://doi.org/10.1182/blood.V116.21.1028.1028

Published: 2010

Journal Articles

Integrated Use of Minimal Residual Disease Classification and IKZF1 Alteration Status Accurately Predicts 79% of Relapses In Pediatric Acute Lymphoblastic Leukemia

Esmé Waanders, PhD, Vincent H.J. van der elden, PhD, Ellen van der Schoot, MD, PhD, Frank N. van Leeuwen, PhD, Simon V. van Reijmersdal, BSc, Valerie de Haas, PhD, Anjo J. Veerman, MD, PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD, PhD, Roland P. Kuiper, PhD, Jacques J.M. van Dongen, PhD

Blood (2010) 116 (21): 272.

https://doi.org/10.1182/blood.V116.21.272.272

Published: 2010

Journal Articles

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

Joost C. van Galen, Roland P. Kuiper, Liesbeth van Emst, Marloes Levers, Esther Tijchon, Blanca Scheijen, Esmé Waanders, Simon V. van Reijmersdal, Christian Gilissen, Ad Geurts van Kessel, Peter M. Hoogerbrugge, Frank N. van Leeuwen

Blood (2010) 115 (23): 4810–4819.

https://doi.org/10.1182/blood-2009-05-223081

Published: 2010

Includes: Supplemental data

Journal Articles

Deletion of IKZF1 in Pediatric Precursor-B ALL Is a Strong Prognostic Marker for Relapse.

Roland P. Kuiper, PhD, Esmee Waanders, PhD, Vincent H.J. Van der Velden, PhD, Simon V van Reijmersdal, Blanca Scheijen, PhD, Jayne Hehir-Kwa, Suzanne T.M. Keijzers-Vloet, Edwin Sonneveld, PhD, Jacques JM van Dongen, Ph.D, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, Peter M. Hoogerbrugge

Blood (2009) 114 (22): 1104.

https://doi.org/10.1182/blood.V114.22.1104.1104

Published: 2009

Journal Articles

Pediatric Precursor-B ALL with BTG1 Deletions Show a Distinct Genomic Profile.

Esmee Waanders, PhD, Frank N. van Leeuwen, PhD, Eugene Verwiel, Simon V van Reijmersdal, Marloes R Levers, Joost C van Galen, PhD, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, Ad Geurts van Kessel, Roland P. Kuiper, PhD

Blood (2009) 114 (22): 3244.

https://doi.org/10.1182/blood.V114.22.3244.3244

Published: 2009

Journal Articles

BTG1, a Gene Frequently Deleted in Pre-B ALL, Controls Glucocorticoid Receptor-Mediated Gene Expression.

Frank N. van Leeuwen, PhD, Joost Casper van Galen, PhD, Roland P. Kuiper, PhD, Liesbeth van Emst, Marloes R Levers, Esther Tijchon, Msc, Blanca Scheijen, Esmee Waanders, PhD, Simon V van Reijmersdal, Christian Gillissen, Msc., Ad Geurts van Kessel, Peter M. Hoogerbrugge

Blood (2009) 114 (22): 3458.

https://doi.org/10.1182/blood.V114.22.3458.3458

Published: 2009

Journal Articles

BTG1 Controls Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia by Regulating Nuclear Receptor-Mediated Transcription.

Joost C. van Galen, MSc, Roland P. Kuiper, PhD, Liesbeth van Emst, BSc, Marloes R. Levers, BSc, Simon V. van Reijmersdal, BSc, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD

Blood (2008) 112 (11): 2262.

https://doi.org/10.1182/blood.V112.11.2262.2262

Published: 2008

Journal Articles

Ikaros Is a Frequently Affected Hematopoietic Differentiation Factor in Pediatric Relapse-Prone Precursor B-Cell Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Frank N. van Leeuwen, PhD, Vincent van der Velden, Simon V. van Reijmersdal, Jeltje de Vries, PhD, Suzanne T.M. Keijzers-Vloet, Jayne Hehir-Kwa, E. van Wering, Jacques JM van Dongen, Ph.D, Peter M. Hoogerbrugge, Ad Geurts van Kessel

Blood (2008) 112 (11): 4144.

https://doi.org/10.1182/blood.V112.11.4144.4144

Published: 2008

Journal Articles

Identification of Novel Genetic Lesions in Myelodysplastic Syndromes Using High Density SNP-Arrays.

Saskia Langemeijer, MD, Roland Kuiper, PhD, Peter Vandenberghe, PhD, Estelle Verburgh, MD, Jan Boezeman, PhD, Ad Geurts van Kessel, PhD, Bert van der Reijden, PhD, Theo de Witte, MD, PhD, Joop Jansen, PhD

Blood (2007) 110 (11): 2430.

https://doi.org/10.1182/blood.V110.11.2430.2430

Published: 2007

Journal Articles

Detection of Genomic Lesions in Childhood Precursor-B Cell ALL in Diagnosis and Relapse Samples Using High Resolution Genomic Profiling.

Roland P. Kuiper, PhD, Frank N. van Leeuwen, PhD, Suzanne T.M. Keijzers-Vloet, Simon V. van Reijmersdal, Jayne Y. Hehir-Kwa, Elisabeth R. van Wering, PhD, Vincent H.J. van der Velden, PhD, Jacques J.M. van Dongen, MD/PhD, Eric F.P.M. Schoenmakers, PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD/PhD

Blood (2007) 110 (11): 995.

https://doi.org/10.1182/blood.V110.11.995.995

Published: 2007

Journal Articles

Simultaneous Analysis of Multiple Chromosomal Aberrations in Chronic Lymphocytic Leukemia (CLL) by Multiplex Ligation-Dependent Probe Amplification (MLPA).

Marian J.P.L. Stevens-Kroef, PhD, Annet Simons, PhD, Michael Egmont Petersen, PhD, Hanneke Gorissen, MD, Yvonne Nanciu, MD, Arjan Buijs, PhD, Reinier Raymakers, PhD, Ad Geurts van Kessel, PhD

Blood (2006) 108 (11): 2329.

https://doi.org/10.1182/blood.V108.11.2329.2329

Published: 2006

Journal Articles

Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization

Margit Schraders, Rolph Pfundt, Huub M. P. Straatman, Irene M. Janssen, Ad Geurts van Kessel, Eric F. P. M. Schoenmakers, Johan H. J. M. van Krieken, Patricia J. T. A. Groenen

Blood (2005) 105 (4): 1686–1693.

https://doi.org/10.1182/blood-2004-07-2730

Published: 2005

NARROW

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Exome Sequencing and Ultra-Deep Sequencing of Paired Diagnosis, Remission and Relapse Samples Reveals the Clonal Diversity and Treatment-Induced Evolution of Childhood Acute Lymphoblastic Leukemia

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Exome Sequencing of Late Recurrence T-Cell Acute Lymphoblastic Leukemia in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes

A Key Role for Tumor Suppressor BTG1 In the Regulation of Metabolic Stress Responses: Implications for Asparaginase Resistance In Pediatric Acute Lymphoblastic Leukemia.

Integrated Use of Minimal Residual Disease Classification and IKZF1 Alteration Status Accurately Predicts 79% of Relapses In Pediatric Acute Lymphoblastic Leukemia

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

Deletion of IKZF1 in Pediatric Precursor-B ALL Is a Strong Prognostic Marker for Relapse.

Pediatric Precursor-B ALL with BTG1 Deletions Show a Distinct Genomic Profile.

BTG1, a Gene Frequently Deleted in Pre-B ALL, Controls Glucocorticoid Receptor-Mediated Gene Expression.

BTG1 Controls Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia by Regulating Nuclear Receptor-Mediated Transcription.

Ikaros Is a Frequently Affected Hematopoietic Differentiation Factor in Pediatric Relapse-Prone Precursor B-Cell Acute Lymphoblastic Leukemia

Identification of Novel Genetic Lesions in Myelodysplastic Syndromes Using High Density SNP-Arrays.

Detection of Genomic Lesions in Childhood Precursor-B Cell ALL in Diagnosis and Relapse Samples Using High Resolution Genomic Profiling.

Simultaneous Analysis of Multiple Chromosomal Aberrations in Chronic Lymphocytic Leukemia (CLL) by Multiplex Ligation-Dependent Probe Amplification (MLPA).

Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization

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American Society of Hematology

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American Society of Hematology

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