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Joana R Costa
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Journal Articles

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia

Sunniyat Rahman, Gianna Bloye, Nadine Farah, Jonas Demeulemeester, Joana R Costa, David O'Connor, Rachael Pocock, Tanya Rapoz-D'Silva, Adam Turna, Lingyi Wang, Soo Wah Lee, Adele K Fielding, Juliette Roels, Roman Jaksik, Małgorzata Dawidowska, Pieter Van Vlierberghe, Suzana Hadjur, Jim R Hughes, James Davies, Alejandro Gutierrez, Michelle Kelliher, Peter Van Loo, Mark A. Dawson, Marc R. Mansour
Journal: Blood
Blood blood.2024024300.
https://doi.org/10.1182/blood.2024024300
Published: 2024
Includes: Supplemental data
Journal Articles

Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

David O’Connor, Jose Espejo Valle-Inclán, Lucia Conde, Gianna Bloye, Sunniyat Rahman, Joana R. Costa, Jack Bartram, Stuart Adams, Gary Wright, Hillary Elrick, Kerry Wall, Sara Dyer, Christopher Howell, Galina Jigoulina, Javier Herrero, Isidro Cortes-Ciriano, Anthony V. Moorman, Marc R. Mansour
Journal: Blood
Blood (2024) 143 (10): 933–937.
https://doi.org/10.1182/blood.2023021906
Published: 2024
Includes: Supplemental data
Journal Articles

The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL

Joana R Costa, David O'Connor, Nurkaiyisah Anuar, Sunniyat Rahman, Nivedita Singh, Zhaodong China, Tanya Rapoz-D'Silva, Yang Li, Kent Fung, Sara Hyseni, Stephen Henderson, George Morrow, Yanping Guo, Javier Herrero, Richard Jenner, Dennis Keppei, A. Thomas Look, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 3046–3047.
https://doi.org/10.1182/blood-2022-166396
Published: 2022
Journal Articles

IRX3 Oncogene Activation in T-ALL through Enhancer Hijacking Caused By fto Intron 8 Deletions

Sunniyat Rahman, Nadine Farah, Jonas Demeulemeester, Joana R Costa, Gianna Bloye, David O'Connor, Rachael Pocock, Adam Turna, SooWah Lee, Adele K. Fielding, Juliette Roels, Małgorzata Dawidowska, Pieter Van Vlierberghe, Suzana Hadjur, Alejandro Gutierrez, Michelle A Kelliher, Simone Riva, Jim R. Hughes, James O.J. Davies, Peter Van Loo, Mark A. Dawson, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 1009–1010.
https://doi.org/10.1182/blood-2022-162930
Published: 2022
Journal Articles

Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency

Brief Report
Joana R. Costa, Valentina S. Caputo, Kalliopi Makarona, D. Mark Layton, Irene A. G. Roberts, Antonio M. Almeida, Anastasios Karadimitris
Journal: Blood
Blood (2014) 124 (20): 3151–3154.
https://doi.org/10.1182/blood-2014-09-598813
Published: 2014
Includes: Supplemental data
Journal Articles

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells

Kalliopi Makarona, Valentina S. Caputo, Joana R. Costa, Binbin Liu, David O’Connor, Deena Iskander, David Roper, Lynn Robertson, Neha Bhatnagar, Evangelos Terpos, Elisabeth Georgiou, Maria Papaioannou, D. Mark Layton, Lucio Luzzatto, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2014) 124 (1): 134–141.
https://doi.org/10.1182/blood-2014-02-553792
Published: 2014
Includes: Supplemental data