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Otto C. Boerman
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Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 3768.
https://doi.org/10.1182/blood.V126.23.3768.3768
Published: 2015
Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 3630.
https://doi.org/10.1182/blood.V124.21.3630.3630
Published: 2014
Journal Articles

Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase

Frank A. D. T. G. Wagener, Andreas Eggert, Otto C. Boerman, Wim J. G. Oyen, Albert Verhofstad, Nader G. Abraham, Gosse Adema, Yvette van Kooyk, Theo de Witte, Carl G. Figdor
Journal: Blood
Blood (2001) 98 (6): 1802–1811.
https://doi.org/10.1182/blood.V98.6.1802
Published: 2001