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Journal Articles

Modulation of the Tumor Suppressor Protein PP2A Using a Small Molecule Agonist Overcomes Multi-Drug Resistance through Mitochondrial Permeability Transition Pore (MPTP) Dependent Induction of Apoptosis in Chronic Lymphocytic Leukemia

Kallesh D. Jayappa, PhD, Caroline Farrington, PhD, Vicki L. Gordon, BS, Shekhar Saha, PhD, Christopher Morris, BS, Krista M. Isaac, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Goutham Narla, MD PhD, Michael J. Weber, PhD

Blood (2020) 136 (Supplement 1): 15–17.

https://doi.org/10.1182/blood-2020-138954

Published: 2020

Journal Articles

A Multi-Drug Tolerant Phenotype Is Induced By Diverse Microenvironmental Agonists in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Kallesh D. Jayappa, DVM, PhD, Konrad J. Cios, BSc (2019), Vicki L. Gordon, BSc, Puja C. Arora, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Michael J. Weber, PhD

Blood (2018) 132 (Supplement 1): 4120.

https://doi.org/10.1182/blood-2018-99-119521

Published: 2018

Journal Articles

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L. Gordon, BSc, Goutham Narla, MD PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD

Blood (2018) 132 (Supplement 1): 2649.

https://doi.org/10.1182/blood-2018-99-116759

Published: 2018

Journal Articles

Extrinsic Factors in the In Vivo Macroenvironment Generate Phenotypic Resistance to BTK/Bcl-2 Targeted Therapies in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L Gordon, BS, Brian J Capaldo, PhD, Stefan Bekiranov, PhD, Julia D Wulfkuhle, Rosa I Gallagher, Emanuel F. Petricoin, PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD

Blood (2016) 128 (22): 754.

https://doi.org/10.1182/blood.V128.22.754.754

Published: 2016

Journal Articles

Ligands That Mimic the Tissue Microenvironment of Replicating Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) Protect Ex Vivo Patient Cell Samples from the Cytotoxicity of Combined Treatment with Ibrutinib and Venetoclax (ABT-199)

Kallesh D. Jayappa, PhD, Craig A. Portell, MD, Vicki Gordon, B.S., Michael E. Williams, MD, Emanuel F. Petricoin, PhD, Timothy P. Bender, PhD, Michael J. Weber, PhD

Blood (2015) 126 (23): 448.

https://doi.org/10.1182/blood.V126.23.448.448

Published: 2015

Journal Articles

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

Eric F. Tewalt, Jarish N. Cohen, Sherin J. Rouhani, Cynthia J. Guidi, Hui Qiao, Shawn P. Fahl, Mark R. Conaway, Timothy P. Bender, Kenneth S. Tung, Anthony T. Vella, Adam J. Adler, Lieping Chen, Victor H. Engelhard

Blood (2012) 120 (24): 4772–4782.

https://doi.org/10.1182/blood-2012-04-427013

Published: 2012

Includes: Supplemental data

Journal Articles

A new window on c-Myb function

Timothy P. Bender

Blood (2010) 116 (8): 1190–1191.

https://doi.org/10.1182/blood-2010-06-287300

Published: 2010

Journal Articles

Requirement of c-Myb for p210 BCR/ABL -dependent transformation of hematopoietic progenitors and leukemogenesis

Maria Rosa Lidonnici, Francesca Corradini, Todd Waldron, Timothy P. Bender, Bruno Calabretta

Blood (2008) 111 (9): 4771–4779.

https://doi.org/10.1182/blood-2007-08-105072

Published: 2008

Includes: Supplemental data

Journal Articles

c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression

Carsten Müller, Rong Yang, Gregory Idos, Nicola Tidow, Sven Diederichs, Olaf M. Koch, Walter Verbeek, Timothy P. Bender, H. Phillip Koeffler

Blood (1999) 94 (12): 4255–4262.

https://doi.org/10.1182/blood.V94.12.4255

Published: 1999

Journal Articles

Further studies on growth factor production by the TC-1 stromal cell line: pre-B stimulating activity

TA Woodward, IK McNiece, PL Witte, P Bender, R Crittenden, DS Temeles, BE Robinson, GB Baber, DH Deacon, PC Isakson

Blood (1990) 75 (11): 2130–2136.

https://doi.org/10.1182/blood.V75.11.2130.2130

Published: 1990

NARROW

Modulation of the Tumor Suppressor Protein PP2A Using a Small Molecule Agonist Overcomes Multi-Drug Resistance through Mitochondrial Permeability Transition Pore (MPTP) Dependent Induction of Apoptosis in Chronic Lymphocytic Leukemia

A Multi-Drug Tolerant Phenotype Is Induced By Diverse Microenvironmental Agonists in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Extrinsic Factors in the In Vivo Macroenvironment Generate Phenotypic Resistance to BTK/Bcl-2 Targeted Therapies in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Ligands That Mimic the Tissue Microenvironment of Replicating Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL) Protect Ex Vivo Patient Cell Samples from the Cytotoxicity of Combined Treatment with Ibrutinib and Venetoclax (ABT-199)

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

A new window on c-Myb function

Requirement of c-Myb for p210 BCR/ABL -dependent transformation of hematopoietic progenitors and leukemogenesis

c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression

Further studies on growth factor production by the TC-1 stromal cell line: pre-B stimulating activity

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American Society of Hematology

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ASH Publications

American Society of Hematology

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