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Pascal Beauchesne
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Journal Articles

Identification of Healthy Donor Phenotypic and Functional Signatures That Predict Allogeneic, Hypoimmune CD19-Directed CAR T Cell Potency

Darin Salloum, Kavita Tundwal, Kwang Bom Choi, Ashley Ranere, Jaclyn Lock, Ben Lam, Jasmin Kristianto, John Yu, Jessica Li, John Lam, Pascal Beauchesne, Allison O'Rourke, Ouwen Liang, Aaron Lampano, Neal van Hoeven, Hosein Kouros-Mehr, Dave Shivak, Weidong Zhang, Tiffany Wan, Lisa Arjes, Christina Chaivorapol, Athena Wong, Adam Johnson, Paul Brunetta, Terry Fry
Journal: Blood
Blood (2023) 142 (Supplement 1): 6810.
https://doi.org/10.1182/blood-2023-188264
Published: 2023
Journal Articles

Functional T Cell Assays Are Predictive of Pre-Clinical Potency to Generate Allogeneic, Hypoimmune CD19 CAR T Cells

Darin Salloum, PhD, Kavita Tundwal, Divy Kangeyan, PhD, Adam Johnson, Neal van Hoeven, PhD, Brian Granger, Jesus Moreno, Ouwen Liang, Pascal Beauchesne, Terry J. Fry, Aaron Foster
Journal: Blood
Blood (2022) 140 (Supplement 1): 4524–4525.
https://doi.org/10.1182/blood-2022-168372
Published: 2022
Journal Articles

Engineered Hypoimmune CAR T Cells Provide Lasting Tumor Control in Fully Immunocompetent Allogeneic Humanized Mice

Xiaomeng Hu, Pascal Beauchesne, Karl Manner, Corie Gattis, Priscilla Ngo, Rowena De Jesus, Chi Young, Frank Wells, Lindong Weng, Kathy White, William E Dowdle, Aaron Foster, Terry Fry, Sonja Schrepfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 1173–1175.
https://doi.org/10.1182/blood-2022-167943
Published: 2022
Journal Articles

Efficient and Specific Multi-Locus Editing of Allogeneic CAR T Cells for Hypoimmunity during Large Scale Manufacture Using Cas12b

Christina Chaivorapol, Pascal Beauchesne, Rowena De Jesus, William E Dowdle, Xiaoyu Chen, Alison Bayley, Yunjiang Qiu, Andrew Birnberg, Yu Zheng, Antonino Montalbano, Angela Liu, Misbah Zafar, Karl Manner, Ramya Ankala, Eleonore Tham, Heer Shah, Ben Lam, Jaclyn Lock, Lindong Weng, Kate Watts, Amanda Valdiosera, Kimberly Davis, Lei Wang, Divy Kangeyan, PhD, Nicolas Devos, Athena Wong, Jason Lih, Edward J Rebar
Journal: Blood
Blood (2022) 140 (Supplement 1): 1606–1607.
https://doi.org/10.1182/blood-2022-167627
Published: 2022