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Journal Articles

REM-422, a Potent, Selective, Oral Small Molecule mRNA Degrader of the MYB Oncogene, Demonstrates Anti-Tumor Activity in Mouse Xenograft Models of AML

Sudeep Prajapati, Michael Cameron, Bryan M. Dunyak, Mengge Shan, Y. Amy Siu, Samantha Levin-Furtney, Joshua Powe, Eileen T.M. Burchfiel, Sarah E. Cabral, Alycen M. Harney, Regina K. Keenan, Kevin M. Larpenteur, Jesper L.V. Maag, Andrew R. Snyder, Dan T. Nguyen, Cecile Blaustein, Silvia Buonamici, Dominic Reynolds, Matthew J. Schnaderbeck, Michael Seiler, Frédéric H. Vaillancourt, Peter Smith, Zaven Kaprielian, Charles Kung
Journal: Blood
Blood (2023) 142 (Supplement 1): 1425.
https://doi.org/10.1182/blood-2023-182676
Published: 2023
Journal Articles

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Jing Sun, PhD, Jing Deng, PhD, Angela Brooks, PhD, Lillian Werner, MS, Fara Faye Regis, BS, Michaela Gruber, MD PhD, Jessica Wong, BS, Zachary Cartun, BS, Michael Seiler, PhD, Peter Smith, PhD, Michael Thomas, PhD, Silvia Buonamici, PhD, Emanuela M. Ghia, PhD, Ekaterina Kim, PhD, Laura Z. Rassenti, PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD, Matthew Meyerson, MDPhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Lili Wang, MD PhD, Matthew S. Davids, MD, Anthony Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 264.
https://doi.org/10.1182/blood.V130.Suppl_1.264.264
Published: 2017
Journal Articles

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Akihide Yoshimi, Kuan-Ting Lin, PhD, Daniel Wiseman, MB, ChB, Andrew M Intlekofer, MD PhD, Bo Wang, Alessandro Pastore, MD, Mohammad Rahman, Stanley Chun-Wei Lee, PhD, Bo Liu, PhD, Jean-Baptiste Micol, MD PhD, Stephane De Botton, Virginie Penard-Lacronique, PhD, Alan H. Shih, MD PhD, Eytan M. Stein, MD, Benjamin H Durham, MD BS, Daichi Inoue, MD PhD, Xiao Jing Zhang, Todd Albrecht, Young Rock Chung, MS, Shouyong Peng, Silvia Buonamici, PhD, James Palacino, PhD, Peter Smith, PhD, Craig B. Thompson, MD, Ross L. Levine, MD, Eric Wagner, PhD, Adrian R. Krainer, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 473.
https://doi.org/10.1182/blood.V130.Suppl_1.473.473
Published: 2017
Journal Articles

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Stanley Chun-Wei Lee, PhD, Khrystyna Dilai, Esther A. Obeng, MDPhD, Eunhee Kim, PhD, Jean-Baptiste Micol, MD PhD, Akihide Yoshimi, MD PhD, Christophe Willekens, MD, Daichi Inoue, Véronique Saada, PharmD, Hana Cho, Young Rock Chung, MS, James Palacino, PhD, Michael Seiler, PhD, Silvia Buonamici, PhD, Peter Smith, Benjamin L. Ebert, MD PhD, Robert Bradley, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2016) 128 (22): 961.
https://doi.org/10.1182/blood.V128.22.961.961
Published: 2016
Journal Articles

Therapeutic Targeting of Spliceosomal Mutant Myeloid Leukemias through Modulation of Splicing Catalysis

Stanley Chun-Wei Lee, PhD, Heidi Dvinge, Eunhee Kim, PhD, Hana Cho, Young Rock Chung, MS, Jean-Baptiste Micol, MD, Benjamin Durham, MD PhD, Young Joon Kim, Michael Thomas, Camille Lobry, PhD, Silvia Buonamici, PhD, Peter Smith, Robert K. Bradley, PhD, Omar Abdel-Wahab
Journal: Blood
Blood (2015) 126 (23): 4.
https://doi.org/10.1182/blood.V126.23.4.4
Published: 2015
Journal Articles

Vascular Endothelial-Cadherin Targeted Alpha-Particle Mediated Vascular Killing and Remodeling Augments Subsequent Chemotherapeutic Efficacy.

Freddy E Escorcia, Erik Henke, PhD, Michael R. McDevitt, PhD, Carlos Villa, Peter Smith-Jones, PhD, Ronald Blasberg, MD, Robert Benezra, David A. Scheinberg, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3054.
https://doi.org/10.1182/blood.V114.22.3054.3054
Published: 2009